公开(公告)号：EP2958591A2

公开(公告)日：2015-12-30

申请号：EP14754905.9

申请日：2014-02-12

申请人： The Brigham and Women's Hospital, Inc.

发明人： GOLDMAN, Aaron ,  KULKARNI, Ashish ,  SENGUPTA, Shiladitya

IPC分类号： A61K39/395

CPC分类号： A61K31/506 ,  A61K31/337 ,  A61K31/517 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/6907 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57484 ,  G01N2500/10 ,  G01N2800/52 ,  A61K2300/00

摘要： The compositions and methods described herein relate to the treatment of cancer, e.g. by reducing the regression of cancer cells from regressing into cancer stem cell-like phenotypes and/or reducing the development of drug-resistant cancer cells. In some embodiments, the compositions and methods relate to inhibitors of PI3K pathway kinases and Src family kinases.

公开(公告)号：EP2861256A1

公开(公告)日：2015-04-22

申请号：EP13805073.7

申请日：2013-06-14

申请人： The Brigham and Women's Hospital, Inc.

发明人： SENGUPTA, Shiladitya ,  KULKARNI, Ashish ,  RAO, Poornima ,  ROY, Bhaskar

IPC分类号： A61K47/28 ,  A61K45/08 ,  A61K31/015 ,  A61K31/337 ,  A61K31/355 ,  A61K31/519 ,  A61P35/00

CPC分类号： A61K47/55 ,  A61K45/06 ,  A61K47/554

摘要： Described herein are compositions and methods relating to chemotherapeutic agent conjugates and the treatment of cancer.