公开(公告)号：EP3231457A1

公开(公告)日：2017-10-18

申请号：EP15867856.5

申请日：2015-12-04

申请人： Toray Industries, Inc. ,  Nanotheta Co, Ltd.

发明人： HOCHI, Motonori ,  SEKIDO, Yuki ,  SAITO, Akihiro ,  TAKEOKA, Shinji ,  OHTSUBO, Shinya ,  HINOKI, Akinari ,  KINOSHITA, Manabu

IPC分类号： A61L31/00 ,  A61L15/16 ,  B32B27/00

CPC分类号： A61L15/28 ,  A61L15/24 ,  A61L15/26 ,  A61L31/042 ,  A61L31/048 ,  A61L31/06 ,  B32B27/00 ,  B32B27/32 ,  C08L5/08 ,  C08L67/04

摘要： The purpose of the present invention is to provide a laminated film that is highly biocompatible and easy to handle, has good pasting ability and contact to an organ tissue and rarely induces infections. The laminated film provided by the present invention, which comprises a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle, and, when stuck to an adherend with curved surface, the laminated film shows excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. Moreover, the acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs, etc. Thus, the laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.

摘要翻译： 本发明的目的是提供一种生物相容性高，操作容易，粘贴性良好，与器官组织接触，极少引起感染的层压薄膜。 由聚乳酸系树脂层和层压在聚乳酸系树脂层侧的一个或多个乙酰化透明质酸层构成的本发明提供的层压膜柔韧性高，易于处理， 粘附到具有曲面的被粘物上时，由于乙酰化透明质酸层可以容易地用聚乳酸系树脂层中的水溶液除去，因此对被粘物显示优异的追随性，粘附性和涂布性， 薄膜形状。 此外，乙酰化透明质酸和聚乳酸类树脂是可生物降解的，因此，该层压膜与皮肤和器官如内脏器官等高度相容。因此，该层压膜最佳地可用作外用皮肤材料 应用如伤口涂层材料，粘合抑制剂和皮肤护理制品。