公开(公告)号：EP1981892B1

公开(公告)日：2014-03-12

申请号：EP07705076.3

申请日：2007-01-30

申请人： UCB Pharma, S.A.

发明人： HUTCHINGS, Martin, Clive ,  ARCHIBALD, Sarah, Catherine ,  BROOKINGS, Daniel, Christopher ,  DAVIS, Jeremy, Martin ,  JOHNSON, James, Andrew ,  LANGHAM, Barry, John ,  NEUSS, Judi, Charlotte

IPC分类号： C07D495/04 ,  A61K31/4365

CPC分类号： C07D495/04

公开(公告)号：EP2315768A1

公开(公告)日：2011-05-04

申请号：EP09766115.1

申请日：2009-06-12

申请人： UCB Pharma, S.A.

发明人： JOHNSON, James, Andrew ,  BROOKINGS, Daniel, Christopher ,  LANGHAM, Barry, John ,  NEUSS, Judi, Charlotte ,  THORNE, Joanna, Rachel

IPC分类号： C07D495/04 ,  A61K31/4436 ,  A61P9/00

CPC分类号： C07D495/04 ,  C07D519/00

摘要： A series of thieno[2,3-6]pyridine derivatives, attached at the 2-position to a substituted anilino moiety, which are substituted in the 3-position by a carbonyl group linked to a pyrrolidin-1-yl ring which in turn forms part of a heteroatom-containing fused bicyclic ring system, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

摘要翻译： 在2-位连接到取代的苯胺基部分的一系列噻吩并[2,3-b]吡啶衍生物，其在3-位上被与吡咯烷-1-基环连接的羰基取代， 形成含杂原子的稠合双环体系的一部分，其是人类MEK（MAPKK）酶的选择性抑制剂，因此在医学中有益，例如在治疗炎症，自身免疫，心血管，增殖（包括肿瘤）和伤害性疾病 。

公开(公告)号：EP2054417A2

公开(公告)日：2009-05-06

申请号：EP07789231.3

申请日：2007-08-15

申请人： UCB Pharma S.A.

发明人： LAING, Victoria, Elizabeth ,  BROOKINGS, Daniel, Christopher ,  CARBERY, Rachel, Jane ,  GASCON SIMORTE, Jose, Miguel ,  HUTCHINGS, Martin, Clive ,  LANGHAM, Barry, John ,  LOWE, Martin, Alexander

IPC分类号： C07D495/04 ,  A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  A61P9/00 ,  A61P35/00

CPC分类号： C07D495/04

摘要： Compounds of formula (I), or a pharmaceutically acceptable salts or solvates thereof : wherein -X- represents a group of formula (a), (b), (c), (d), (e), (f) or (g) : Being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive

公开(公告)号：EP1981892A1

公开(公告)日：2008-10-22

申请号：EP07705076.3

申请日：2007-01-30

申请人： UCB Pharma, S.A.

发明人： HUTCHINGS, Martin, Clive ,  ARCHIBALD, Sarah, Catherine ,  BROOKINGS, Daniel, Christopher ,  DAVIS, Jeremy, Martin ,  JOHNSON, James, Andrew ,  LANGHAM, Barry, John ,  NEUSS, Judi, Charlotte

IPC分类号： C07D495/04 ,  A61K31/4365

CPC分类号： C07D495/04

摘要： A series of thieno[2,3-b]pyridine derivatives which are substituted in the 2- position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.