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公开(公告)号：EP2744812A2
公开(公告)日：2014-06-25
申请号：EP12753225.7
申请日：2012-08-15
发明人： BROOKINGS, Daniel Christopher , FORD, Daniel James , GHAWALKAR, Anant Ramrao , HERMAN, Jean , HUANG, Qiuya , KULISA, Claire Louise , LOUAT, Thierry , NEUSS, Judi Charlotte , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D495/04 , C07D513/04 , C07D519/00 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/519 , C07D513/04 , C07D519/00
摘要： A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
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公开(公告)号：EP2776445A1
公开(公告)日：2014-09-17
申请号：EP12801466.9
申请日：2012-11-08
发明人： BROOKINGS, Daniel Christopher , FORD, Daniel James , FRANKLIN, Richard Jeremy , GHAWALKAR, Anant Ramrao , KULISA, Claire Louise , NEUSS, Judi Charlotte , REUBERSON, James Thomas
IPC分类号： C07D513/04 , A61K31/519 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： C07D513/04 , A61K31/519 , C07D519/00
摘要： A series of thiazolo[5,4-
d ]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.-
公开(公告)号：EP2776445B1
公开(公告)日：2016-08-10
申请号：EP12801466.9
申请日：2012-11-08
发明人： BROOKINGS, Daniel Christopher , FORD, Daniel James , FRANKLIN, Richard Jeremy , GHAWALKAR, Anant Ramrao , KULISA, Claire Louise , NEUSS, Judi Charlotte , REUBERSON, James Thomas
IPC分类号： C07D513/04 , A61K31/519 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： C07D513/04 , A61K31/519 , C07D519/00
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公开(公告)号：EP2935269A1
公开(公告)日：2015-10-28
申请号：EP13814962.0
申请日：2013-12-20
发明人： FORD, Daniel James , FRANKLIN, Richard Jeremy , GHAWALKAR, Anant Ramrao , HORSLEY, Helen Tracey , HUANG, Qiuya , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , C07D471/04
摘要： A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
摘要翻译： 在4-位被二氮杂单环，桥连双环或螺环部分取代的一系列吡唑并[3,4-d]嘧啶衍生物有益于治疗和/或预防各种人类疾病，包括炎性，自身免疫 和肿瘤疾病; 病毒性疾病和疟疾; 和器官和细胞移植排斥反应。
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公开(公告)号：EP2903990A1
公开(公告)日：2015-08-12
申请号：EP13776992.3
申请日：2013-10-02
发明人： KULISA, Claire Louise , BROOKINGS, Daniel Christopher , FORD, Daniel James , FRANKLIN, Richard Jeremy , REUBERSON, James Thomas , GHAWALKAR, Anant Ramrao
IPC分类号： C07D495/04 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/424 , C07D413/14
摘要： Compounds of formula (I) i.e. monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives substituted by an optionally substituted oxazolin-2-yl moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
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公开(公告)号：EP2935269B1
公开(公告)日：2018-04-11
申请号：EP13814962.0
申请日：2013-12-20
发明人： FORD, Daniel James , FRANKLIN, Richard Jeremy , GHAWALKAR, Anant Ramrao , HORSLEY, Helen Tracey , HUANG, Qiuya , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , C07D471/04
摘要： A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
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公开(公告)号：EP2903990B1
公开(公告)日：2017-06-14
申请号：EP13776992.3
申请日：2013-10-02
发明人： KULISA, Claire Louise , BROOKINGS, Daniel Christopher , FORD, Daniel James , FRANKLIN, Richard Jeremy , REUBERSON, James Thomas , GHAWALKAR, Anant Ramrao
IPC分类号： C07D495/04 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/424 , C07D413/14
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公开(公告)号：EP2744812B1
公开(公告)日：2016-07-20
申请号：EP12753225.7
申请日：2012-08-15
发明人： BROOKINGS, Daniel Christopher , FORD, Daniel James , GHAWALKAR, Anant Ramrao , HERMAN, Jean , HUANG, Qiuya , KULISA, Claire Louise , LOUAT, Thierry , NEUSS, Judi Charlotte , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D495/04 , C07D513/04 , C07D519/00 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/519 , C07D513/04 , C07D519/00
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