公开(公告)号：EP1812007A4

公开(公告)日：2009-04-01

申请号：EP05823123

申请日：2005-11-02

申请人： UNIV NORTHWESTERN ,  UNIV PASTEUR

发明人： WATTERSON D MARTIN ,  VAN ELDIK LINDA ,  HAIECH JACQUES ,  HIBERT MARCEL ,  BOURGUIGNON JEAN-JACQUES ,  VELENTZA ANASTASIA ,  HU WENHUI ,  ZASADZKI MAGDELENA

IPC分类号： A61K31/535 ,  A01N43/58 ,  A01N43/60 ,  A61K31/495 ,  A61K31/50 ,  C07D237/26 ,  C07D237/36 ,  C07D413/00 ,  C07D487/00

CPC分类号： C07D403/12 ,  C07D237/36 ,  C07D401/12 ,  C07D401/14 ,  C07D498/06

公开(公告)号：EP1812408A4

公开(公告)日：2012-05-02

申请号：EP05817588

申请日：2005-11-02

申请人： UNIV NORTHWESTERN ,  UNIV STRASBOURG ,  CENTRE NAT RECH SCIENT

发明人： WATTERSON D MARTIN ,  VAN ELDIK LINDA ,  HAIECH JACQUES ,  HIBERT MARCEL ,  BOURGUIGNON JEAN-JACQUES ,  VELENTZA ANASTASIA ,  HU WENHUI ,  ZASADZKI MAGDELENA

IPC分类号： C07D237/00 ,  A01N43/58 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/502 ,  C07D237/02 ,  C07D403/00 ,  C07D403/12 ,  C07D405/00 ,  C07D409/00

CPC分类号： C07D401/12 ,  A61K31/502 ,  C07D237/20 ,  C07D237/24 ,  C07D237/34 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07H19/16

摘要： The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications. Compounds of Formula Ia or Ib or wherein R is a substituted amino group, R 2 is an unsaturated 5 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, R 3 , R 4 , R 5 , and R 6 are hydrogen, and R 7 is absent; or a pharmaceutically acceptable salt thereof.