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    Sensizitation of cancer cells to therapy using sina targeting genes from the 1p and 19q chromosomal regions
    1.
    发明公开
    Sensizitation of cancer cells to therapy using sina targeting genes from the 1p and 19q chromosomal regions 有权
    使用的siNA靶基因从染色体区域1P和19Q癌细胞对治疗的敏化

    公开(公告)号：EP2336320A1

    公开(公告)日：2011-06-22

    申请号：EP10167455.4

    申请日：2007-07-23

    申请人： UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)

    发明人： Berger François ,  Pelletier, Laurent ,  Issartel, Jean-Paul ,  Boccard, Sandra

    IPC分类号： C12N15/113 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713

    CPC分类号： C12N15/111 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/31

    摘要： The invention relates to the identification of genes involved in resistance of cancer cells to therapy, to short nucleic acid molecules which inhibit the expression of these genes by RNA interference and to their use as adjuvant in cancer therapy, to sensitize cancer cells to conventional anticancer agents ; said short nucleic acid molecules are double-stranded short interfering nucleic acid molecules comprising a sense and an antisense region, wherein the sense region comprises a nucleotide sequence that is selected from the group consisting of: the sequences SEQ ID NO: 15, 11, 13, 14, 30, 31, 38, 46, 64 and 70 and the sequences having at least 70 % identity, preferably at least 80 % identity, more preferably at least 90 % identity with said sequences, and the antisense region comprises a nucleotide sequence that is complementary to the sense region.

    摘要翻译： 本发明涉及在癌细胞对治疗的抗性相关基因的鉴定，一种通过RNA干扰和它们作为在癌症治疗中的佐剂，使用抑制合成的基因的表达致敏癌细胞对常规抗癌剂短的核酸分子 ; 所述短核酸分子是双链短干扰核酸分子包含有义和反义区，worin有义区包含的核苷酸序列并从所述组包括选自：序列SEQ ID NO：15，11，13 ，14，30，31，38，46，64和70，并具有至少70％同一性，优选至少80％的同一性，更优选与所述序列至少90％的同一性，并且所述反义区的序列包含核苷酸序列 确实有义区域互补。