公开(公告)号：EP0831903B1

公开(公告)日：2010-04-14

申请号：EP96916841.8

申请日：1996-05-31

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： GROTENDORST, Gary, R. ,  BRADHAM, Douglass, M., Jr.

IPC分类号： A61K39/395 ,  A61K38/18 ,  C07H21/04 ,  C07K16/22 ,  C07K14/475

CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K38/1841 ,  A61K38/39 ,  C12N5/0655 ,  A61K2300/00

公开(公告)号：EP0831903A1

公开(公告)日：1998-04-01

申请号：EP96916841.0

申请日：1996-05-31

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： GROTENDORST, Gary, R. ,  BRADHAM, Douglass, M., Jr.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P17 ,  A61P27 ,  A61P35 ,  A61P43 ,  C07K14 ,  C12N5 ,  C12Q1 ,  G01N33

CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K38/1841 ,  A61K38/39 ,  C12N5/0655 ,  A61K2300/00

摘要： The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides CTGF, and including 5'and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-β responsive element upstream of the polynucleotide encoding CTGF structural gene.