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公开(公告)号：EP3150627A1
公开(公告)日：2017-04-05
申请号：EP16197733.5
申请日：2010-02-12
发明人： Bikker, Floris Jacob , van Dijk, Albert , Mars-Groenendijk, Rosalia , Veldhuizen, Edwin Johannes Adrianus , van der Kleij, Desiree , Haagsman, Hendrik , Molhoek, Elisabeth Margaretha
CPC分类号： C07K14/465 , A61K39/39 , A61K2039/55516 , C07K7/08 , C07K14/47
摘要： The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.
摘要翻译： 本发明涉及与野生型CMAP27肽相比具有良好抗微生物活性和低溶血活性的CMAP27衍生物。 这些衍生物可用于抗生素治疗或杀菌组合物。 本发明还包括使用CMAP27和/或其衍生物作为佐剂。
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公开(公告)号：EP3150627B1
公开(公告)日：2018-11-21
申请号：EP16197733.5
申请日：2010-02-12
发明人： Bikker, Floris Jacob , van Dijk, Albert , Mars-Groenendijk, Rosalia , Veldhuizen, Edwin Johannes Adrianus , van der Kleij, Desiree , Haagsman, Hendrik , Molhoek, Elisabeth Margaretha
CPC分类号： C07K14/465 , A61K39/39 , A61K2039/55516 , C07K7/08 , C07K14/47
摘要： The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.
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