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    Isomerases, nucleic acids encoding them and methods for making and using them
    1.
    发明公开
    Isomerases, nucleic acids encoding them and methods for making and using them 审中-公开
    异构酶，编码它们的核酸，以及制备方法及其用途

    公开(公告)号：EP2706122A2

    公开(公告)日：2014-03-12

    申请号：EP13195575.9

    申请日：2008-12-22

    申请人： Verenium Corporation

    发明人： Weiner, David ,  Burke, Ellen ,  Bueno, Analia ,  Cuenca, Joslin ,  De Souza, Mervyn L. ,  Kollmann, Sherry ,  Luginbuhl, Peter

    IPC分类号： C12Q1/533 ,  C12N9/90 ,  C12N15/61 ,  A61K38/52 ,  A23K1/165 ,  A23G4/12

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the rearrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明涉及基因的反弹于酶，多核苷酸编码的酶，利用搜索多核苷酸和多肽，更具体的涉及具有异构酶活性的酶，例如，消旋酶活性，例如，氨基酸消旋酶活性，丙氨酸消旋酶活性，和/或差向异构酶活性， 和/或催化的原子的重新排列的分子内，催化一种异构体转化为另一种，催化的光学活性底物转化成一总状花序，其全部在光学上是不活动的，催化底物的相互转换对映异构体围绕催化的立体化学反转 在仅具有一个不对称中心基板的不对称碳原子，围绕催化的配置的立体化学反转在不对称碳原子中具有多于一个不对称中心的基底，和/或催化的氨基酸外消旋化。 因此，本发明提供的酶，组合物，方法用于制备药物组合物，医药中间体，抗生素，甜味剂，肽酶，肽类激素，燃料，燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆，和洗涤剂包括以本发明在雅舞蹈的多肽或多核苷酸。