公开(公告)号：EP3004153A1

公开(公告)日：2016-04-13

申请号：EP14807031.1

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  BHOOPATHI, Praveen ,  DAS, Swadesh, K. ,  EMDAD, Luni ,  SARKAR, Devanand ,  SOKHI, Upneet

IPC分类号： C07K14/52

摘要： Recombinant therapeutic cytokines (“therakines”) for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 (“M4”) not normally found in nature that has anti-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.

公开(公告)号：EP3004153B1

公开(公告)日：2019-10-30

申请号：EP14807031.1

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  BHOOPATHI, Praveen ,  DAS, Swadesh, K. ,  EMDAD, Luni ,  SARKAR, Devanand ,  SOKHI, Upneet

IPC分类号： C07K14/54 ,  C12N15/62 ,  C12N15/24 ,  A61K38/20