公开(公告)号：EP2846819B1

公开(公告)日：2017-05-03

申请号：EP13729107

申请日：2013-05-09

申请人： YEDA RES & DEV

发明人： SAGI IRIT ,  WONG EITAN ,  AFIK RAN

IPC分类号： A61K38/17 ,  C07K14/00

CPC分类号： A61K38/4886 ,  C12N9/6489 ,  C12Y304/24086

摘要： A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.

摘要翻译： 公开了一种治疗炎性疾病的方法。 该方法包括向受试者施用治疗有效量的包含TNF-α转化酶（TACE）的前结构域的多肽，所述多肽缺乏所述TACE的催化结构域，所述多肽在选择的位点包含修饰 来自由R58，R56和K57组成的组，其使得所述多肽抵抗弗林蛋白酶降解，所述多肽能够下调TACE的活性，由此治疗炎性疾病。