公开(公告)号：EP0980388A1

公开(公告)日：2000-02-23

申请号：EP98924811.7

申请日：1998-05-20

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY of the Hebrew University of Jerusalem ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： VOLSKY, David, J. ,  KOTLER, Moshe

IPC分类号： C07K14/16 ,  A61K38/55

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/16322

摘要： The present invention is directed to novel inhibitors of an HIV or other lentiviral or retroviral protease which are capable of inhibiting HIV or other lentiviral or retroviral replication. As such, these inhibitors are capable of reducing, eliminating or preventing viral infection. The inhibitors are peptides and polypeptides having an amino acid sequence which corresponds to the amino acid sequence of a lentiviral Vif protein (Vif-derived protease inhibitor). The invention is also directed to compositions containing the inhibitors of the invention and to methods for using such compositions in the prevention or treatment of HIV or other lentiviral and retroviral infections. The invention is also directed to methods for identifying such inhibitors in cellular model systems, HIV-infected cells, in vitro high flux assay systems, and animal model systems.