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公开(公告)号：EP0322779A3
公开(公告)日：1991-05-08
申请号：EP88121561.0
申请日：1988-12-23
CPC分类号： C07K5/06139 , A61K38/00
摘要： Benzolactam compounds of the general formula
or isomers thereof as well as salts thereof inclusive of hydrates and/or solvates forms thereof, and benzolactam compounds of the general formula
wherein each of the symbols is as defined in the specification. The compound (I) exhibit antiamnesic activity, and are useful as brain function-improving drugs. The compounds (a) and (b) are useful as an intermediate for said compounds (I).-
公开(公告)号：EP0292923A3
公开(公告)日：1990-06-27
申请号：EP88108278.8
申请日：1988-05-24
发明人： Murakami, Shu , Ikebe, Tsuguo , Hakamada, Ichiro , Yaoka, Osamu
CPC分类号： C07K5/0222 , A61K38/00 , Y02P20/55
摘要： Piperidine compounds of the formula:
or isomers thereof as well as pharmaceutically acceptable salt and/or hydrate forms thereof, and piperidine compounds of the formula:
or isomers thereof as well as salt and/or hydrate forms thereof. In the above formulae, A represents a methylene group, an oxygen atom or a sulfur atom; B represents an oxygen atom or a sulfur atom; R¹ and R² independently represent a hydrogen atom, a lower alkyl group or an aralkyl group; R³ represents a hydrogen atom or an amino protecting group; Z represents an amino group or a protected amino group, a hydroxy group, or a reactive atom or group; m represents 1 or 2; and n represents the integer of 0 to 3. Piperidine compounds (I) possess an inhibitory activity against angiotensin-converting enzyme, and exhibit a long lasting hypotensive activity and are useful as anti-hypertensive agents. Piperidine compounds (II) are useful as intermediates for said piperidine compounds (I).-
3.发明公开Benzolactam compounds and pharmaceutical uses thereof 失效Benzolaktam-Verbindungen und deren pharmazeutische Verwendungen。
公开(公告)号：EP0322779A2
公开(公告)日：1989-07-05
申请号：EP88121561.0
申请日：1988-12-23
CPC分类号： C07K5/06139 , A61K38/00
摘要： Benzolactam compounds of the general formula
or isomers thereof as well as salts thereof inclusive of hydrates and/or solvates forms thereof, and benzolactam compounds of the general formula
wherein each of the symbols is as defined in the specification.
The compound (I) exhibit antiamnesic activity, and are useful as brain function-improving drugs. The compounds (a) and (b) are useful as an intermediate for said compounds (I).摘要翻译： 通式
的苯并内酰胺化合物或其异构体以及其盐，包括水合物和/或溶剂化物形式，以及通式为CHEM的苯并内酰胺化合物，其中每个符号如说明书中所定义。 化合物（I）表现出抗病毒活性，可用作脑功能改善药物。 化合物（a）和（b）可用作所述化合物（I）的中间体。 -
公开(公告)号：EP0292923A2
公开(公告)日：1988-11-30
申请号：EP88108278.8
申请日：1988-05-24
发明人： Murakami, Shu , Ikebe, Tsuguo , Hakamada, Ichiro , Yaoka, Osamu
CPC分类号： C07K5/0222 , A61K38/00 , Y02P20/55
摘要： Piperidine compounds of the formula:
or isomers thereof as well as pharmaceutically acceptable salt and/or hydrate forms thereof, and piperidine compounds of the formula:
or isomers thereof as well as salt and/or hydrate forms thereof.
In the above formulae, A represents a methylene group, an oxygen atom or a sulfur atom; B represents an oxygen atom or a sulfur atom; R¹ and R² independently represent a hydrogen atom, a lower alkyl group or an aralkyl group; R³ represents a hydrogen atom or an amino protecting group; Z represents an amino group or a protected amino group, a hydroxy group, or a reactive atom or group; m represents 1 or 2; and n represents the integer of 0 to 3.
Piperidine compounds (I) possess an inhibitory activity against angiotensin-converting enzyme, and exhibit a long lasting hypotensive activity and are useful as anti-hypertensive agents. Piperidine compounds (II) are useful as intermediates for said piperidine compounds (I).摘要翻译： 下式的哌啶化合物或其异构体及其药学上可接受的盐和/或水合物形式，以及下式的哌啶化合物或其异构体以及其盐和/或水合物形式。 在上式中，A表示亚甲基，氧原子或硫原子; B表示氧原子或硫原子; R 1和R 2独立地表示氢原子，低级烷基或芳烷基; R 3表示氢原子或氨基保护基; Z表示氨基或保护的氨基，羟基或反应性原子或基团; m表示1或2; 哌啶化合物（I）对血管紧张素转换酶具有抑制活性，具有持久的低血压活性，可作为抗高血压药物使用。 哌啶化合物（II）可用作所述哌啶化合物（I）的中间体。
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