公开(公告)号：EP2552957A4

公开(公告)日：2013-11-20

申请号：EP11761857

申请日：2011-03-28

申请人： ZYMEWORKS INC

发明人： D ANGELO IGOR ,  BLEILE DUSTIN ,  TOM-YEW STACEY A L ,  ESCOBAR-CABRERA ERIC ,  LARIO PAOLA I ,  OHRN ANDERS ,  POON DAVID K Y ,  DIXIT SURJIT B

IPC分类号： C07K16/00 ,  A61K39/395 ,  A61P35/00 ,  A61P37/00 ,  C07K14/735 ,  C07K16/28 ,  C07K19/00 ,  C12N15/13 ,  G06F19/10

CPC分类号： C07K16/32 ,  C07K14/70535 ,  C07K16/00 ,  C07K16/082 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/283 ,  C07K16/2851 ,  C07K16/2887 ,  C07K16/464 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G06F19/16

摘要： Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.