公开(公告)号：EP3383996B1

公开(公告)日：2024-10-16

申请号：EP16871591.0

申请日：2016-12-02

发明人： INGBER, Donald, E. ,  HAMILTON, Geraldine ,  JANG, Kyung-Jin ,  HANEY, Suzzette ,  PATEL, Payal ,  HERLAND, Anna ,  RESNIKOFF, Joshua

IPC分类号： C12M3/00 ,  C12N5/22 ,  G01N33/483 ,  G01N33/50 ,  B01L99/00 ,  B81B7/00

公开(公告)号：EP3701265B1

公开(公告)日：2024-09-11

申请号：EP18869602.5

申请日：2018-10-25

IPC分类号： G01N33/574 ,  C12N5/22 ,  G01N21/00 ,  G01N33/567

CPC分类号： G01N33/567 ,  G01N33/57426

公开(公告)号：EP4192939A2

公开(公告)日：2023-06-14

申请号：EP21856573.7

申请日：2021-08-10

申请人： Angiocrine Bioscience, Inc.

发明人： GINSBERG, Michael, Daniel ,  LANDEEN, Lee ,  FINNEGAN, Paul, William ,  FRASER, John, K.

IPC分类号： C12N5/073 ,  C12N5/16 ,  C12N5/22

公开(公告)号：EP4084827A1

公开(公告)日：2022-11-09

申请号：EP20910389.4

申请日：2020-12-29

申请人： Chase Therapeutics Corporation

发明人： CHASE, Thomas N. ,  CLARENCE-SMITH, Kathleen

IPC分类号： A61K45/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  C12N5/22 ,  G01N33/483

公开(公告)号：EP3831934A1

公开(公告)日：2021-06-09

申请号：EP20208309.3

申请日：2016-12-02

申请人： The Johns Hopkins University

发明人： COLIN, Paul ,  KONSTANTOPOULOS, Konstantinos ,  QUINONES-HINOJOSA, Alfredo

IPC分类号： C12N5/071 ,  C12N5/09 ,  C12N5/22 ,  G01N33/50 ,  A61P35/00

摘要： The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.

公开(公告)号：EP3384010B1

公开(公告)日：2020-11-25

申请号：EP16871617.3

申请日：2016-12-02

申请人： The Johns Hopkins University

发明人： KONSTANTOPOULOS, Konstantinos ,  PAUL, Colin ,  QUINONES-HINOJOSA, Alfredo

IPC分类号： C12N5/071 ,  C12N5/09 ,  C12N5/22 ,  G01N33/50 ,  A61P35/00

公开(公告)号：EP3739041A1

公开(公告)日：2020-11-18

申请号：EP20179501.0

申请日：2015-03-26

申请人： The Salk Institute for Biological Studies

发明人： EVANS, Ronald, M. ,  YOSHIHARA, Eiji ,  DOWNES, Michael R. ,  YU, Ruth T ,  ATKINS, Annette, R.

IPC分类号： C12N5/10 ,  C12N5/074 ,  C12N5/22 ,  A61K35/39

摘要： The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for treatment of type 1 diabetes, type 2 diabetes, or a related disorder.

公开(公告)号：EP3702458A1

公开(公告)日：2020-09-02

申请号：EP18870256.7

申请日：2018-10-26

申请人： Edigene Inc.

发明人： YUAN, Pengfei ,  FANG, Riguo ,  YU, Lingling ,  XIA, Penghui ,  WANG, Jia ,  LIANG, Fucai

IPC分类号： C12N15/113 ,  C12N5/22 ,  C12N9/22 ,  A61K35/18 ,  A61P7/06

摘要： Provided is a method for gene editing of an enhancer site of the BCL11A in hematopoietic stem cells. The genetically modified hematopoietic stem cells have the functions of normal cells, and can significantly increase the expression of fetal hemoglobin so as to be used in the treatment of β thalassemia and sickle cell anemia.

公开(公告)号：EP3600261A1

公开(公告)日：2020-02-05

申请号：EP18770880.5

申请日：2018-03-21

申请人： Pharmacyte Biotech, Inc.

发明人： WAGGONER, Kenneth L. ,  CRABTREE, Gerald W.

IPC分类号： A61K9/48 ,  A61K9/50 ,  A61K9/51 ,  A61K9/56 ,  A61K9/58 ,  C12N5/16 ,  C12N5/22 ,  C12N15/63

公开(公告)号：EP2989464B1

公开(公告)日：2018-12-26

申请号：EP14787491.1

申请日：2014-04-23

申请人： Chromocell Corporation

发明人： RADHAKRISHNA, Harish ,  JENKINS, Maya ,  ANOBILE, Jonathan ,  SLADE, Louise

IPC分类号： G01N33/566 ,  C12N5/22

CPC分类号： G01N33/502 ,  G01N33/566

摘要： The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R38, TAS2R39, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists.