利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

768 条记录 (耗时 0.027 秒)

    Molecules able to modulate the expression of at least a gene involved in degradative pathways and uses thereof
    91.
    发明公开
    Molecules able to modulate the expression of at least a gene involved in degradative pathways and uses thereof 审中-公开
    与能力分子以调节至少一种参与降解途径基因的表达及其用途

    公开(公告)号：EP2218458A1

    公开(公告)日：2010-08-18

    申请号：EP09152778.8

    申请日：2009-02-13

    申请人： Fondazione Telethon

    发明人： Ballabio, Andrea ,  Sardiello, Marco

    IPC分类号： A61K38/17 ,  C07K14/47

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K14/47

    摘要： A molecule able to modulate the expression of at least a gene involved in degradative pathways so to enhance the cellular degradative pathways and prevent or antagonize the accumulation of toxic compounds in a cell wherein said molecule acts on a CLEAR element; and/or on the TFEB protein activity or amount.
    The molecule may be used in the treatment of neurodegenerative and/or lysosomal storage disorders.

    摘要翻译： 的分子能调节至少在降解途径涉及一个基因的表达，从而增强细胞降解途径和防止或拮抗有毒化合物在worin所述分子起作用的CLEAR元件上的小区中的积累; 和/或在TFEB蛋白质活性或量。 该分子可以在神经变性和/或溶酶体贮积症的治疗中使用。

    Method and apparatus for generating virtual teeth
    93.
    发明公开
    Method and apparatus for generating virtual teeth 审中-公开
    Verfahren und Vorrichtung zur Erzeugung von virtuellenZähnen

    公开(公告)号：EP2159724A2

    公开(公告)日：2010-03-03

    申请号：EP09166361.7

    申请日：2009-07-24

    申请人： E-WOO Technology Co. Ltd

    发明人： Kim, Heon Joo ,  Kim, Sung Kuk ,  Kim, Jae Doc

    IPC分类号： G06F19/00

    CPC分类号： G05B19/401 ,  A61C9/0046 ,  G05B2219/35014 ,  G05B2219/35209 ,  G05B2219/35485 ,  G05B2219/45167 ,  G06F19/00 ,  G06T19/00 ,  G16H50/50

    摘要： The present invention relates to a recording medium a method and an apparatus for generating virtual teeth. According to an embodiment of the present invention, a method for generating virtual teeth includes(a) acquiring a tooth image having three-dimensional information from teeth including a damaged tooth; (b) determining an image of a virtual tooth to be inserted into a position of the damaged tooth in a tooth image library having predetermined three-dimensional information and inserting the determined virtual tooth image into the acquired tooth image; and (c) modifying the virtual tooth image by considering tooth images positioned at upper and lower sides or right and left sides of the virtual tooth image. According to the embodiment of the present invention, it is possible to produce a prosthesis most suitable for the state of patient's teeth only once and an operator can minimize post-processing of the produced prosthesis. Further, a patient can minimize a clinic time and decrease the number of times of hospital visits.

    摘要翻译： 本发明涉及记录介质，用于产生虚拟齿的方法和装置。 根据本发明的实施例，一种用于产生虚拟牙齿的方法包括：（a）从包括损伤牙齿的牙齿获取具有三维信息的牙齿图像; （b）在具有预定三维信息的牙齿图像库中确定要插入损伤牙齿的位置的虚拟牙齿的图像，并将确定的虚拟牙齿图像插入所获取的牙齿图像中; 以及（c）通过考虑位于虚拟牙齿图像的上侧和下侧或左右两侧的牙齿图像来修改虚拟牙齿图像。 根据本发明的实施例，可以生产最适合患者牙齿状态的假体一次，并且操作者可以最小化所产生的假体的后处理。 此外，患者可以最小化诊所的时间并减少医院的次数。

    Chimeric U2 snRNA molecules carrying antisense sequences against the splice junctions of the dystrophin gene and their therapeutic applications
    96.
    发明公开
    Chimeric U2 snRNA molecules carrying antisense sequences against the splice junctions of the dystrophin gene and their therapeutic applications 有权
    嵌合U1和U2 snRNA的分子携带的反义序列针对肌营养不良蛋白基因的剪接点和它们的治疗应用

    公开(公告)号：EP2151497A2

    公开(公告)日：2010-02-10

    申请号：EP09176221.1

    申请日：2003-05-06

    申请人： Universita'Degli Studi di Roma "La Sapienza"

    发明人： Bozzoni, Irene ,  De Angelis, Fernanda Gabriella

    IPC分类号： C12N15/11 ,  A61K48/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2310/111

    摘要： A gene is described that encodes for a snRNA modified such that it contains an antisense sequence complementary to at least one of the two splice junctions at 5' and/or 3' of one of the exons encoding for a protein of therapeutic interest, whose sequence should be skipped during the splicing process that converts the pre-mRNA to the mature mRNA. The gene is particularly advantageous which it contain segments complementary to both splice junctions. If introduced into appropriate vectors, the gene is useful in gene therapy, particularly in the treatment of Duchenne Muscular Dystrophies. dystrophic diseases.

    摘要翻译： 的基因被描述那样编码为一个snRNA的改性检查做到了包含反义序列，以至少在5编码治疗兴趣的蛋白质，其序列的外显子中的一个的两个剪接点中的一个“和/或3”互补 如果processthat的mRNA前体转换为成熟的mRNA剪接过程中被跳过。 的基因是特别有利的，它包含为Both剪接点的互补片段。 如果导入适当载体中，该基因是在基因治疗中是有用的，特别是在杜兴氏肌营养不良的治疗。 营养不良性疾病。

    Reflection type optical sensor device
    99.
    发明公开
    Reflection type optical sensor device 有权
    Optisches Reflexionssresorement

    公开(公告)号：EP2124263A2

    公开(公告)日：2009-11-25

    申请号：EP09160742.4

    申请日：2009-05-20

    申请人： Gwangju Institute of Science and Technology

    发明人： Lee, Yongtak ,  Song, Youngmin

    IPC分类号： H01L31/173

    CPC分类号： H01L27/15 ,  H01L31/02327 ,  H01L31/173 ,  H01L33/46 ,  H01L33/58 ,  H01S5/005 ,  H01S5/0262 ,  H01S5/183

    摘要： Provided is a reflection type optical sensor device including: a semiconductor light source (210) being formed by providing a light emitting region on a predetermined region of a substrate (230); and a photo-detection element (220) being integrated on the same substrate (230) as the substrate where the semiconductor light source (210) is formed to surround an outer circumferential surface of the semiconductor light source (210), and including a light receiving region. When the light emitted from the semiconductor light source (210) is reflected by an external object, the photo-detection element (220) may detect the light to sense the object. Through this, it is possible to reduce cost and ensure a small size. Also, the photo-detection element (220) is constructed to surround the outer circumferential surface of the semiconductor light source (210), and thus more accurately detect the light.

    摘要翻译： 提供了一种反射型光学传感器装置，包括：通过在基板的预定区域上提供发光区域形成的半导体光源（210）; 和与所述半导体光源（210）形成为包围所述半导体光源（210）的外周面的基板相同的基板（230）上的光检测元件（220），并且包括光 接收区域。 当从半导体光源（210）发射的光被外部物体反射时，光检测元件（220）可以检测光以感测物体。 通过这种方式，可以降低成本并确保小尺寸。 此外，光检测元件（220）被构造成围绕半导体光源（210）的外周表面，从而更准确地检测光。

    METHOD OF PREPARING STANDARD SERUM MIXTURE FOR DETERMINING ACTIVITY OF AN ALLERGEN AND APPLICATION OF THE SERUM MIXTURE
    100.
    发明公开
    METHOD OF PREPARING STANDARD SERUM MIXTURE FOR DETERMINING ACTIVITY OF AN ALLERGEN AND APPLICATION OF THE SERUM MIXTURE 有权
    制造方法的标准血清MIXTURE用于确定过敏原及血清混合物的效价的应用

    公开(公告)号：EP2124064A1

    公开(公告)日：2009-11-25

    申请号：EP07871769.1

    申请日：2007-12-14

    申请人： Zhejiang Wolwo Biotech CO., LTD.

    发明人： HU, Gengxi

    IPC分类号： G01N33/96

    CPC分类号： G01N33/96 ,  G01N33/6854

    摘要： The present invention provides a method for preparing standardized serum mixture for determining allergen potency which comprises: 1) providing multiple serum samples from patients moderately hypersensitive to said allergen; 2) determining the relative content of sIgE against said allergen in each serum sample, obtaining the mean value of the relative content of sIgE of said multiple serum samples, and obtaining deviation value of the relative content of sIgE of each serum with respect to said mean value; 3) removing at least 5% of serum samples that have the largest and smallest deviation values respectively, and mixing the residual sera at the same volume. The invention also relates to the serum mixture prepared by the method as well as the use of such serum mixture.

    摘要翻译： 本发明提供了一种制备用于采矿确定性过敏效力，它包括标准化的血清混合物的方法：1）提供来自病人适度过敏的所述变应原的多个血清样品; 2）确定的采矿的SiGe的相对含量对每个血清样品中的所述变应原，获得的SiGe所述多血清样品的相对含量的平均值，并获得每个血清的特异性IgE的相对含量的偏差值相对于所述平均 值; 3）除去血清样品中的至少5％分别thathave大最大和最小偏差值，并在同一体积混合的残余血清。 因此本发明涉及由该方法以及利用搜索血清混合物的制备的血清混合物。