公开(公告)号：EP1682535A1

公开(公告)日：2006-07-26

申请号：EP04790967.6

申请日：2004-10-28

申请人： F. HOFFMANN-LA ROCHE AG

发明人： ACKERMANN, Jean ,  AEBI, Johannes ,  BINGGELI, Alfred ,  GRETHER, Uwe ,  HIRTH, Georges ,  KUHN, Bernd ,  MAERKI, Hans-Peter ,  MEYER, Markus ,  MOHR, Peter ,  WRIGHT, Matthew, Blake

IPC分类号： C07D403/12 ,  C07D401/12 ,  A61K31/4439 ,  A61K31/506 ,  A61P3/10

CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D403/12

摘要： This invention relates to compounds of formula (I), wherein one of R6, R7 and R8 is formula (II) and X, Y1 to Y4 , R1 to R 14 and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.

公开(公告)号：EP1638970A1

公开(公告)日：2006-03-29

申请号：EP04739841.7

申请日：2004-06-11

申请人： F. HOFFMANN-LA ROCHE AG

发明人： BOEHRINGER, Markus ,  KUHN, Bernd ,  MATTEI, Patrizio ,  NARQUIZIAN, Robert

IPC分类号： C07D471/06 ,  A61P3/10

CPC分类号： C07D471/04 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2853 ,  A61K9/2866 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4875

摘要： The present invention relates to compounds of formula (I) wherein R1, R2 R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

公开(公告)号：EP1599477A1

公开(公告)日：2005-11-30

申请号：EP04710346.0

申请日：2004-02-12

申请人： F. HOFFMANN-LA ROCHE AG

发明人： FOLEY, Louise, Helen ,  HUBY, Nicholas, John, Silvester ,  PIETRANICO-COLE, Sherrie, Lynn ,  YUN, Weiya ,  DUNTEN, Pete, William

IPC分类号： C07D473/04 ,  A61K31/52 ,  A61P3/10

CPC分类号： C07D473/04 ,  C07D473/06 ,  C07D473/08

摘要： The present invention is concerned with sulfonamide substituted xanthine derivatives of formula (I) or a pharmaceutically acceptable salts or prodrugs thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

公开(公告)号：EP1548445A3

公开(公告)日：2005-11-23

申请号：EP04029641.0

申请日：2004-12-15

申请人： F. HOFFMANN-LA ROCHE AG ,  Claes-Goran Ostenson

发明人： Clerc, Roger G. ,  Duchateau-Nguyen, Guillemette ,  Gardes, Christophe ,  Mizrahi, Jacques ,  Ostenson, Claes-Goran

IPC分类号： G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/502 ,  C12Q1/6837 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/68 ,  G01N2500/00

摘要： The present invention relates to novel targets for identifying compounds that may be useful for the prevention and treatment of obesity.