公开(公告)号：EP0349130B1

公开(公告)日：1994-04-27

申请号：EP89305624.2

申请日：1989-06-05

申请人： INTERMEDICS INC.

发明人： Baker, Ross G., Jr. ,  Haluska, Edward A. ,  Vandegriff, Joseph W.

IPC分类号： A61N1/365 ,  A61B5/04

CPC分类号： A61N1/3704 ,  A61N1/3706

公开(公告)号：EP0583246A1

公开(公告)日：1994-02-23

申请号：EP92905209.0

申请日：1992-01-21

申请人： INTERMEDICS INC.

发明人： SCHROEPPEL, Edward, A.

IPC分类号： A61N1

CPC分类号： A61N1/365

摘要： Appareil servant à mesurer un potentiel électrique dans un corps humain par échantillonnage dudit potentiel dans un intervalle de temps choisi et par enregistrement de la valeur de ce potentiel à la fin dudit intervalle. La valeur enregistrée dudit potentiel sera rétablie en tant que valeur initiale à la fin d'un second intervalle. L'appareil comprend un circuit de chronométrage destiné à identifier des intervalles appropriés. On décrit des éléments destinés à échantillonner et à enregistrer la valeur du potentiel électrique à un moment donné et à restituer à une électrode le potentiel mesuré, à un second moment choisi.

公开(公告)号：EP0516820A1

公开(公告)日：1992-12-09

申请号：EP92903179.0

申请日：1991-12-06

申请人： INTERMEDICS INC.

发明人： SPEHR, Paul, R. ,  FOSTER, Arthur, J.

IPC分类号： A61N1

CPC分类号： A61N1/0573

摘要： Conducteur endocardiaque implantable (10) avec une spirale aiguisée rétractable (34). Le piston (36) comprend un passage central (42) destiné à recevoir un stylet spécialisé (44). Le stylet comprend un fil métallique flexible (56) présentant une extrémité ou un bout (60) distal élargi. Un tube coulissant élastomère (58) s'adapte sur le fil. Lorsque l'extrémité proximale du stylet est introduit dans le passage du piston, le fil peut être légèrement tiré, ce qui attire l'extrémité élargie dans le tube et coince celui-ci contre les parois du passage. Lorsqu'on manipule le stylet, la spirale peut être exposée hors du conducteur ou rétractée à l'intérieur de celle-ci, comme il est souhaité.

公开(公告)号：EP0344878A3

公开(公告)日：1991-03-20

申请号：EP89301222.9

申请日：1989-02-09

申请人： INTERMEDICS INC.

发明人： Stotts, Lawrence J.

IPC分类号： A61N1/362

CPC分类号： A61N1/3708 ,  A61N1/3704

摘要： A cardiac pacemaker (10) has a sense amplifier (20) responsive to signals representative of cardiac activity for passing signal components lying in a selectively variable pass band and for selectively varying the gain of the passed signal. A pair of signal comparators (58, 59) constituting switched capacitor amplifiers, associated with the sense amplifier (20), are responsive to the filtered and gain adjusted signal for comparison of its magnitude to predetermined target levels for determination of heart rate and the need for change of rate. Two target levels are provided in each comparator (58, 59) for comparison with the level of the detected signal, by multiplexing the switched capacitors. Another switched capacitor amplifier (99) is used to develop a voltage reference level insensitive to temperature, supply voltage, and circuit components, for deriving the target levels for the comparison. Still another multiplexed switched capacitor amplifier comparator (125) is used to develop a first target level to regulate the level of the pacing stimulus, and a second target level for comparison with the supply voltage level of the pacemaker as a measure of the point at which the pacemaker requires replacement.

公开(公告)号：EP0253505A3

公开(公告)日：1988-11-23

申请号：EP87305279

申请日：1987-06-15

申请人： INTERMEDICS, INC.

发明人： Haluska, Edward A. ,  Whistler, Stephen J. ,  Baker, Ross G., Jr. ,  Calfer, Richard V.

IPC分类号： A61N01/365

CPC分类号： A61N1/3621

摘要： A cardiac stimulator is provided for detecting and treating ventricular tachyarrhythmias of a patient's heart. The stimulator includes means for selectively dividing the heart rate continuum into regions including at least two classes of tachycardia (TACH-1, TACH-2, TACH-3), contiguous to each other and of progressively higher heart rate ranges, the lowest and highest of the tachycardia classes being bounded respectively by a sinus rate region (SINUS) and a fibrillation region (FIB) of the continuum. Means are provided for selectively adjusting the boundaries between the tachycardia classes and between the lowest and highest of those classes and the respective sinus rate and fibrillation regions, to correspondingly adjust the rate ranges of the classes in a desired manner. Cardiac events are selectively detected anywhere within the continuum and a distinction made between normal and abnormal tachycardias among the detected events. A detected abnormal tachycardia is then treated with any of a multiplicity of therapy regimens of differing degrees of aggressiveness, toward terminating the detected tachycardia.

公开(公告)号：EP0280526A2

公开(公告)日：1988-08-31

申请号：EP88301578.6

申请日：1988-02-24

申请人： INTERMEDICS, INC.

发明人： Baker, Ross G., Jr. ,  Whistler, Stephen J. ,  Calfee, Richard V. ,  Ideker, Raymond E. ,  Haluska, Edward A.

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61N1/3906

摘要： An implantable defibrillator is described comprising means for detecting fibrillation, electrical generating means responsive to the detection of fibrillation for producing a biphasic waveform (33-35, 42-46) in which each phase is characterised by an impulse of predetermined polarty, magnitude and duration, in which the first phase is of greater duration than the second phase, and means for delivering the biphasic waveform to provide electrical shock to the ventricles of the heart.

摘要翻译： 描述了可植入除颤器，其包括用于检测原纤维的装置，响应于原纤化检测的产生装置，用于产生双相波形（33-35,42-46），其中每个相的特征在于预定的波动，幅度和持续时间的脉冲 ，其中第一阶段具有比第二阶段更长的持续时间，以及用于递送双相波形以向心脏的心室提供电击的装置。

公开(公告)号：EP0253505A2

公开(公告)日：1988-01-20

申请号：EP87305279.9

申请日：1987-06-15

申请人： INTERMEDICS, INC.

发明人： Haluska, Edward A. ,  Whistler, Stephen J. ,  Baker, Ross G., Jr. ,  Calfer, Richard V.

IPC分类号： A61N1/365

CPC分类号： A61N1/3621

摘要： A cardiac stimulator is provided for detecting and treating ventricular tachyarrhythmias of a patient's heart. The stimulator includes means for selectively dividing the heart rate continuum into regions including at least two classes of tachycardia (TACH-1, TACH-2, TACH-3), contiguous to each other and of progressively higher heart rate ranges, the lowest and highest of the tachycardia classes being bounded respectively by a sinus rate region (SINUS) and a fibrillation region (FIB) of the continuum. Means are provided for selectively adjusting the boundaries between the tachycardia classes and between the lowest and highest of those classes and the respective sinus rate and fibrillation regions, to correspondingly adjust the rate ranges of the classes in a desired manner. Cardiac events are selectively detected anywhere within the continuum and a distinction made between normal and abnormal tachycardias among the detected events. A detected abnormal tachycardia is then treated with any of a multiplicity of therapy regimens of differing degrees of aggressiveness, toward terminating the detected tachycardia.

摘要翻译： 提供心脏刺激器用于检测和治疗患者心脏的室性快速心律失常。 刺激器包括用于选择性地将心率连续区分为包括至少两类彼此相邻且心率范围逐渐增高的至少两类心动过速（TACH-1，TACH-2，TACH-3）的区域的装置，最低和最高 的心动过速分别由连续区的窦率区（SINUS）和颤动区（FIB）界定。 提供了用于选择性地调节心动过速类别之间以及这些类别中的最低和最高与相应的窦率和原纤化区域之间的边界的手段，以期望的方式相应地调整类别的速率范围。 心脏事件有选择性地在连续区内的任何地方检测到，并且在检测到的事件之间区分正常和异常心动过速。 然后用任何不同侵入度的治疗方案中的任何一种治疗检测到的异常心动过速，以终止检测到的心动过速。

公开(公告)号：EP0237316A2

公开(公告)日：1987-09-16

申请号：EP87302020.0

申请日：1987-03-10

申请人： INTERMEDICS, INC.

发明人： Ross, G. Baker Jr

IPC分类号： A61N1/05 ,  A61N1/365 ,  A61N1/372

CPC分类号： A61N1/0573

摘要： An electrode (10, 35, 50, 65) for use in cardiac pacing has a substrate (15, 87) composed of a material conventionally employed for pacing electrodes, and a surface layer or film (20, 75, 85, 95) of iridium oxide overlying the substrate. For use as a stimulating cathodic electrode and a sensing electrode, the iridium oxide layer is arranged to be in cardiac tissue stimulating relationship when the electrode is in proper position with respect to the patient's heart. The electrode impresses electrical stimuli on the excitable myocardial tissue to provide pacing at very low stimulation thresholds. At the completion of each stimulus, the electrode is capable of abruptly sensing, within an interval less than 100 ms thereafter, the electrical activity of the heart in response to the stimulus to reliably verify capture. The surface of the electrode may be provided with recesses (65) to which the iridium oxide layer may be confined. An iridium oxide layer may be provided on both the cathode and the anode for effecticient transduction at the electrode-electrolyte interface formed by the surface of the iridium oxide layer and the surrounding body fluid and tissue.

摘要翻译： 用于心脏起搏的电极（10,35,50,55）具有由通常用于起搏电极的材料构成的衬底（15,87）和表面层或膜（20,75,85,95） 覆盖衬底的氧化铱。 为了用作刺激性阴极电极和感测电极，当电极相对于患者的心脏处于适当位置时，氧化铱层被布置成处于心脏组织刺激关系中。 电极在可激励的心肌组织上施加电刺激以在非常低的刺激阈值下提供起搏。 在每次刺激完成时，电极能够在其后小于100ms的间隔内突然感测响应于刺激以可靠地验证捕获的心脏的电活动。 电极的表面可以设置有可以限制氧化铱层的凹部（65）。 氧化铱层可以设置在阴极和阳极两者上，用于在由氧化铱层的表面和周围的体液和组织形成的电极 - 电解质界面处有效地转导。

公开(公告)号：EP0113176A1

公开(公告)日：1984-07-11

申请号：EP83306953.7

申请日：1983-11-14

申请人： INTERMEDICS, INC.

发明人： Baker, Ross G, Jr. ,  Calfee, Richard V.

IPC分类号： A61N1/362 ,  G06F15/42

CPC分类号： A61N1/3622

摘要： A microprocessor-controlled pacemaker is programmed to extend an atrial refractory interval in response to the detection of events which could initiate a pacer sustained tachycardia. The extended atrial refractory interval ensures that a spurious atrial event resulting from retrograde conduction of a ventricle event will not cause a pace of the ventricle.

公开(公告)号：EP1233814A1

公开(公告)日：2002-08-28

申请号：EP00980456.8

申请日：2000-11-17

申请人： Intermedics, Inc.

发明人： ALT, Eckhard

IPC分类号： A61N1/39

CPC分类号： A61N1/36542 ,  A61N1/3925 ,  A61N1/3962

摘要： A medical interventional device (13) is structured for implantation in a human patient (10), to respond to detection of cardiac dysrhythmias. Dysrhythmias in either the atrial or ventricular chambers (24, 29) are automatically treated by a selected therapy regimen consisting of pacing, cardioverting or defibrillating waveforms of predetermined type and energy content to the chamber diagnosed as that in which the dysrhythmia originated. The device incorporates a DDD or DDD-R pacemaker (not numbered) for dual chamber sensing of electrical (ECG) activity, and for constant atrioventricular synchronization. A microprocessor-based logic subsystem (not numbered) diagnoses the origin of a rhythm disorder and identifies the originating heart chamber. The electrode system (21, 26, 42, 38) for delivering the selected therapy includes a single lead (22, 27) for pacing, sensing, cardioversion and defibrillation associated with each of the right atrial and ventricular chambers (24, 29). The device's metal case (15) may be used as the defibrillator's counter-electrode. A cardiac electrode (42) implanted in the distal coronary sinus improves defibrillation and left heart stimulation for better hemodynamic response. Dual chamber rate responsive pacing further improves hemodynamics.