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134 条记录 (耗时 0.015 秒)

    TRICYCLIC CRF RECEPTOR ANTAGONISTS
    94.
    发明公开
    TRICYCLIC CRF RECEPTOR ANTAGONISTS 审中-公开
    三环CRF受体拮抗剂

    公开(公告)号：EP1345938A1

    公开(公告)日：2003-09-24

    申请号：EP01271065.3

    申请日：2001-12-21

    申请人： Neurocrine Biosciences, Inc.

    发明人： HADDACH, Mustapha

    IPC分类号： C07D471/16 ,  A61K31/53 ,  A61P25/00

    CPC分类号： C07D471/16 ,  A61K31/53 ,  C07D487/16

    摘要： CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1, R2, R5, R6, X and Y are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

    Neue Farbstoffe zum Massefärben von Kunststoffen
    96.
    发明公开
    Neue Farbstoffe zum Massefärben von Kunststoffen 失效
    Neue Farbstoffe zumMassefärbenvon Kunststoffen。

    公开(公告)号：EP0683212A1

    公开(公告)日：1995-11-22

    申请号：EP95106924.4

    申请日：1995-05-08

    申请人： BAYER AG

    发明人： Roschger, Peter, Dr. ,  Hederich, Volker, Dr. ,  Michaelis, Stephan, Dr. ,  Kröck, Friedrich Wilhelm, Dr.

    IPC分类号： C09B57/12 ,  C07D471/16 ,  C07D487/16 ,  C08K5/3465

    CPC分类号： C07D471/16 ,  C07D487/16 ,  C08K5/3465 ,  C09B57/12

    摘要： Es wurden Farbstoffe der Formel

    worin

    Z ein Rest zur Vervollständigung eines 3,4- oder 2,3-Pyridinylen-, eines 4,5-Pyrmidinylen-, eines 3,4- oder 4,5-Pyridazinylen- oder eines 2,3-Pyrazinylen-Systems bedeutet und
    X, Y, m und n die in der Beschreibung genannten Bedeutungen besitzen,
    gefunden, die sich besonders gut zum Massefärben von Kunststoffen, insbesondere von Thermoplasten, eignen.

    摘要翻译： 式（I）的azaphthaloperinone染料是新的：Z = gp。 完成3,4-或2,3-亚吡啶，4.5-嘧啶基，3,4-或4,5-哒嗪亚基或2,3-吡嗪亚系; X =烷基，卤素，硝基，氯磺酰基，芳氧基磺酰基，OH，烷氧基，酰氧基，氨基磺酰基（选自烷基或芳基）或稠合的脂环族或杂环; Y =烷基，芳基，卤素，硝基，氯磺酰基，酰氧基（尤其是芳氧基磺酰基），氨基或氨基磺酰基（均可通过烷基或芳基取代）或稠合的脂环族或芳香环; m = 0-6; n = 0-3。

    7H-benzo (b)pyrazino(1,2-d)pyrrolo(3,2,1-jk)(1,4)benzodiazepines, a process for their preparation and their use as medicaments
    97.
    发明公开
    7H-benzo (b)pyrazino(1,2-d)pyrrolo(3,2,1-jk)(1,4)benzodiazepines, a process for their preparation and their use as medicaments 失效
    7-BENZO（B）吡嗪（1,2-D）吡咯烷（3,2,1-JK）（1,4）苯并嗪，其制备方法及其作为药物使用

    公开(公告)号：EP0402807A3

    公开(公告)日：1991-10-02

    申请号：EP90110946.2

    申请日：1990-06-09

    申请人： HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

    发明人： Glamkowski, Edward J. ,  Kurys, Barbara E.

    IPC分类号： C07D487/16 ,  A61K31/55

    CPC分类号： C07D487/16

    摘要： The present invention relates to 7H-benzo[b]pyrazino­[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines of the formula
    wherein R is hydrogen, loweralkyl, or a group of the formula COO(CR¹Z) m CR²R³R⁴, wherein R¹, R², R³, and R⁴ are independently hydrogen or loweralkyl, Z is hydrogen, loweralkyl, or halogen, and m is 0 or 1; X and Y are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; the dotted line represents an optional carbon-tocarbon bond; an optical isomer thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for treating depression alone or in combination with inert adjuvants. The invention relates also to a process and intermediates for the preparation of the above compounds.

    7H-benzo (b)pyrazino(1,2-d)pyrrolo(3,2,1-jk)(1,4)benzodiazepines, a process for their preparation and their use as medicaments
    98.
    发明公开
    7H-benzo (b)pyrazino(1,2-d)pyrrolo(3,2,1-jk)(1,4)benzodiazepines, a process for their preparation and their use as medicaments 失效
    -7H-苯并（b）中吡嗪并（1,2-D）吡咯并（3,2,1-JK）（1,4）苯并二氮杂，它们的制备方法以及它们作为药物的用途。

    公开(公告)号：EP0402807A2

    公开(公告)日：1990-12-19

    申请号：EP90110946.2

    申请日：1990-06-09

    申请人： HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

    发明人： Glamkowski, Edward J. ,  Kurys, Barbara E.

    IPC分类号： C07D487/16 ,  A61K31/55

    CPC分类号： C07D487/16

    摘要： The present invention relates to 7H-benzo[b]pyrazino­[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines of the formula
    wherein R is hydrogen, loweralkyl, or a group of the formula COO(CR¹Z) m CR²R³R⁴, wherein R¹, R², R³, and R⁴ are independently hydrogen or loweralkyl, Z is hydrogen, loweralkyl, or halogen, and m is 0 or 1; X and Y are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; the dotted line represents an optional carbon-tocarbon bond; an optical isomer thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for treating depression alone or in combination with inert adjuvants.
    The invention relates also to a process and intermediates for the preparation of the above compounds.

    摘要翻译： 本发明涉及向7H-苯并[b]吡嗪并[1,2-d]吡咯并[3,2,1-JK] [1,4]式 worin R是氢的苯二氮类，低级烷基，或一 式COO（CR <1> Z）的组MCR <2> [R <3> [R <4>，worin - [R <1>，R <2> [R <3>，和R <4>是unabhängig氢或 低级烷基，Z是氢，低级烷基，卤素或，和m是0或1; X和Y独立地是氢，卤素，低级烷基，或三氟甲基; 可选的碳 - tocarbon键的虚线darstellt; 的它们的旋光异构体，或其药学上可接受的酸加成盐，它们是单独使用或与惰性的佐剂组合治疗抑郁症是有用的。 因此，本发明涉及用于上述化合物的制备方法和中间体。