公开(公告)号：EP1921116A1

公开(公告)日：2008-05-14

申请号：EP06712275.4

申请日：2006-01-24

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： TAKAHASHI, Shinjiro ,  DEJIMA, Yoshiyuki ,  SHIRASAKI, Yasuo

IPC分类号： C09B43/16 ,  B41J2/01 ,  B41M5/00 ,  C07D251/52 ,  C07D251/70 ,  C09B33/06 ,  C09D11/00

CPC分类号： C07D251/52 ,  C07D251/70 ,  C09D11/328 ,  Y10T428/24802

摘要： The present invention relates to a water-soluble azo compound represented by the following formula (1)
[KA 1]

(wherein, A represents a hydroxyl group, a morpholino group, an amino group, an aliphatic amine residue which may have a substituent, aromatic amine residue which may have a substituent, a phenoxy group which may have a substituent or an alkoxy group which may have a substituent, R 1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R 2 represents a substituent selected from a hydrogen atom, a halogen atom, a nitro group and a hydroxyl group, n represents an integer number of 1 to 3, respectively) as free acid and an ink composition comprising the same. Said azo compound has hue having high vividness suitable for inkjet recording, said ink composition is excellent in storage stability, and an inkjet recorded article by using this is excellent in fastnesses such as moisture fastness, ozone gas fastness and light fastness.

摘要翻译： 本发明涉及由下式（1）表示的水溶性偶氮化合物[KA 1]（其中，A表示羟基，吗啉代基，氨基，可具有取代基的脂肪族胺残基， 可以具有取代基的芳族胺残基，可以具有取代基的苯氧基或可以具有取代基的烷氧基，R 1表示氢原子或具有1〜4个碳原子的烷基，R 2表示选择的取代基 分别为氢原子，卤原子，硝基和羟基，n分别表示1〜3的整数）和含有它们的油墨组合物。 所述偶氮化合物具有适于喷墨记录的高鲜艳度的色调，所述油墨组合物的储存稳定性优异，并且使用该喷墨记录物具有优异的耐湿性，耐臭氧气体牢度和耐光性等坚牢度。

公开(公告)号：EP1250328B1

公开(公告)日：2006-07-05

申请号：EP01907700.7

申请日：2001-01-25

申请人： Merck Sante

发明人： MOINET, Gérard ,  CRAVO, Daniel ,  DOARE, Liliane ,  KERGOAT, Micheline ,  MESANGEAU, Didier

IPC分类号： C07D251/10 ,  C07D251/52 ,  C07D251/72 ,  A61P3/10 ,  A61K31/53

CPC分类号： A61K31/53 ,  A61K31/58 ,  C07D251/10 ,  C07D251/52 ,  C07D251/72

摘要： . The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. Said compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome.

公开(公告)号：EP1651636A1

公开(公告)日：2006-05-03

申请号：EP04778036.6

申请日：2004-07-09

申请人： NEUROGEN CORPORATION

发明人： BAKTHAVATCHALAM, Rajagopal ,  HODGETTS, Kevin, J. ,  HUTCHISON, Alan, J. ,  OHLIGER, Robert ,  YOON, Taeyoung ,  ZHENG, Xiaozhang

IPC分类号： C07D401/12 ,  C07D251/52 ,  C07D251/54 ,  C07D401/14 ,  A61K31/506 ,  A61K31/53 ,  A61P17/02 ,  A61P11/06 ,  A61P19/00 ,  A61P13/02 ,  A61P11/14 ,  A61P3/04

CPC分类号： C07D401/12 ,  A61K31/506 ,  A61K31/53 ,  C07D251/52 ,  C07D251/54 ,  C07D401/14 ,  G01N33/566

摘要： Substituted heterocyclic diarylamine analogues of Formula I are provided: wherein X, Y and Z are independently N or optionally substituted C, and other variables are as described in the specification. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

公开(公告)号：EP1177180B1

公开(公告)日：2005-07-20

申请号：EP00927036.4

申请日：2000-04-25

申请人： LANXESS Deutschland GmbH

发明人： VOGT, Uwe ,  BROCKMANN, Rolf ,  ROICK, Thomas ,  GASSEN, Karl-Rudolf ,  FELDHUES, Ulrich

IPC分类号： C07D251/52 ,  D06L3/12

CPC分类号： C11D3/42 ,  C07D251/50 ,  C07D251/52 ,  D21H21/30

公开(公告)号：EP1028949B1

公开(公告)日：2005-03-23

申请号：EP98955485.2

申请日：1998-10-20

申请人： Bayer CropScience GmbH

发明人： KEHNE, Heinz ,  WILLMS, Lothar ,  WALDRAFF, Christian ,  DIETRICH, Hansjörg ,  BIERINGER, Hermann ,  ROSINGER, Christopher ,  AULER, Thomas

IPC分类号： C07D239/52 ,  A01N47/36 ,  C07D239/47 ,  C07D239/42 ,  C07D239/46 ,  C07D251/46 ,  C07D251/16 ,  C07D251/22 ,  C07D251/52 ,  C07D239/56 ,  C07D275/06 ,  C07C311/15 ,  C07C311/54 ,  C07C309/86

CPC分类号： C07D275/06 ,  C07C311/16 ,  C07D521/00

摘要： The invention relates to compounds of formula (I) or the salts thereof, wherein R1, R3 = H, (substituted) hydrocarbon radical (KW) or (substituted) heterocyclyl, which comprise inclusive substituents 1-30 C-atoms, R?2 = R0-Q0¿-, wherein R0 = H, (substituted) KW or (substituted) heterocyclyl radical, each inclusive substituents with 1-30 C-atoms and Q0 = direct binding or -O-, -SO¿2?, -NH-, -N[(C1-C6)alkyl]-, -CO-, -CO-NH- or -O-CO-NH-; R?4¿ = H, halogen, NO¿2?, CN, (C1-C4)alkyl, (C1-C4)alkoxyl, [(C1-C4)alkyl]-carbonyl or [(C1-C4)alkoxyl] carbonyl, whereby each of the remaining 4 radicals can be halogenated; R?5¿ = H or (C¿1?-C4)alkyl; Q = O or NR*; R* = H, (C1-C4)alkyl, (C3-C4)alkenyl or (C3-C4)alkynyl, whereby each of the 3 remaining radicals can be substituted by halogen, (C1-C4)alkoxyl and/or (C1-C4)alkylthio, W = O or S; X, Y = H, halogen, (C1-C4)alkyl, (C1-C4)alkoxyl, (C1-C4)alkylthio, whereby each of the 3 remaining radicals can be substituted by halogen, (C1-C4)alkoxyl and/or (C1-C4)alkylthio, or mono- or di[((C1-C4)alkyl]-amino (C3-C4)cycloalkyl, (C2-C5)alkenyl, (C2-C5)alkynyl, (C2-C5)alkenyloxyl or (C2-C5)alkynyloxyl, Z = CH or N. The inventive compounds are suitable as herbicides or plant growth regulators, for example, for combating harmful plants in crop plants, also transgenic crop plants. Using the method, the compounds can be produced in accordance with claim 6 by partially novel intermediate products (c.f. compounds (II)* and (IX)' in accordance with claims 12 and 13).

公开(公告)号：EP1473289A1

公开(公告)日：2004-11-03

申请号：EP02783612.1

申请日：2002-11-25

申请人： Sankyo Company, Limited

发明人： Meguro, Masaki, c/o SANKYO COMPANY, Ltd. ,  Oda, Tomiichiro, c/o SANKYO COMPANY, Ltd. ,  Nakagami, Yasuhiro, c/o SANKYO COMPANY, Ltd. ,  Marumoto, Shinji, c/o SANKYO COMPANY, Ltd. ,  Koyama, Kazuo, c/o SANKYO COMPANY, Ltd. ,  Kaneko, Isao, c/o SANKYO COMPANY, Ltd.

IPC分类号： C07D237/20 ,  C07D239/48 ,  C07D239/50 ,  C07D251/18 ,  C07D251/52 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P25/28 ,  A61P43/00

CPC分类号： C07D239/48 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  C07D237/20 ,  C07D237/22 ,  C07D239/50 ,  C07D241/20 ,  C07D251/18 ,  C07D251/48 ,  C07D251/52 ,  C07D251/70

摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors:
(where, R 1 and R 2 are H or alkyl; Z 1 and Z 2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z 3 is alkoxy, SH, alkylthio, NH 2 , mono- or di-alkylamino, OH or halogeno; Z 4 and Z 5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

摘要翻译： 本发明涉及预防或治疗药用于治疗阿尔茨海默氏病，或淀粉样蛋白纤丝的形成抑制剂，其包括通式（I）的化合物作为活性成分低于或其药理学上允许的盐; 并因此具有特定的取代基，或它们的药理学上允许的盐，其是作为预防或治疗药用于治疗阿尔茨海默病有价值的，或作为淀粉样蛋白纤丝的形成抑制剂含氮杂芳基衍生物：（其中R <1>和R <2>是H或烷基; Z <1>和Z <2>为H，烷基，烷氧基，卤代烷基或卤代; Z <3>为烷氧基，SH，烷硫基，NH 2，单 - 或二 - 烷基氨基，OH或 卤代; Z <4>和Z <5>是H或卤代;并且A是4,6-嘧啶-1,3-二基，1,3,5-三嗪-2,6-二基等）。

公开(公告)号：EP1466908A1

公开(公告)日：2004-10-13

申请号：EP04290373.2

申请日：2004-02-12

申请人： L'OREAL

发明人： Richard, Hervé ,  Luppi, Bernadette

IPC分类号： C07D251/70 ,  A61K7/42 ,  C08K5/3492 ,  C07D251/52 ,  C07D251/48

CPC分类号： C07D251/70 ,  A61K8/4966 ,  A61Q17/04 ,  C07D251/48 ,  C07D251/52 ,  C08K5/34922

摘要： L'invention concerne des compositions photoprotectrices, comprenant des dérivés de s-triazine de formule (1) possédant au moins un sel d'acide para-amino benzalmalonique greffé à titre de filtres solaires actifs dans le domaine des rayonnements UV.
dans laquelle au moins un des radicaux R 1 ,R 1 ' et R 1 ", identiques ou différents, désigne un groupe chromophore répondant à la formule

摘要翻译： 新-s-三嗪与可在化妆品式蒸发散被并入用于皮肤和头发的光防护为UV-A和UV-B辐射的吸收性能对 - aminobenzalmalonic酸的接枝盐衍生物。 通式（1）化合物; [图像] R 1，R 1“和R 1”“：要么生色团对应于餐饮（2-8） - 酮的条件下式之一所做的至少一个基团R 1，R” 1和R“” 1是发色团 （2）和不超过一个是发色基团（3）或（ii）OH，1 - 20℃的烷氧基或1 - 20℃的单或二烷基氨基（该基团可以含有O，Si或硅氧烷基团的一个或多个原子。 [图像] R 21 - 8C烷基; n：0,1或2; A：H.碱金属（Na或K），铵，1 - 20C单，二或三铵，或2 - 20C单，二 或三 - 链烷醇; R 3-和R 41 20C烷基或烷氧基，或2 - 20C烯烃（该基团可以含有一个或O-的更多原子，Si或三硅氧烷基团）; R 5为H或OH; X：O，S或NR 6 ，R 6为H或1 - 因此4C烷基独立权利要求中包括用于容纳所述s-三嗪衍生物和它们的用途的组合物..

公开(公告)号：EP1022273B1

公开(公告)日：2004-07-14

申请号：EP99300442.3

申请日：1999-01-21

申请人： TOYO INK MANUFACTURING CO., LTD.

发明人： Kamikubo, Takashi ,  Hirasawa, Yuuji ,  Omura, Toru

IPC分类号： C07D251/70 ,  C07D251/52 ,  C07D251/46 ,  C09D17/00 ,  C09D7/02 ,  C09D11/02 ,  C09B67/00

CPC分类号： C09D11/03 ,  C07D251/46 ,  C07D251/52 ,  C07D251/70 ,  C09B67/0085 ,  C09D7/45

摘要： A colourless or only slightly coloured pigment dispersing agent which can be used to disperse pigments having various hues, and which has the general formula (1) wherein k is from 1 to 3, 1 is from 0 to 2, R1 is an amino group, R2 is a halogen atom, an amino group, a nitro group, a hydroxyl group, an alkoxy group, a carboxyl group, a sulfonic acid group, an optionally substituted alkyl group or an optionally substituted alkenyl group, X1 is -O- or -NR3- wherein R3 is a hydrogen atom, an optionally substituted alkyl group or an optionally substituted alkenyl group, Y1 is a amino derivative and Y2 is an amino derivative, a hydroxyl group, an alkoxy group or a group wherein X1, R2, R2 k and l are defined above.rsin

公开(公告)号：EP1293504A3

公开(公告)日：2003-11-05

申请号：EP02025811.7

申请日：1997-07-02

申请人： Ciba Specialty Chemicals Holding Inc.

发明人： Metzger, Georges ,  Reinehr, Dieter ,  Luther, Helmut

IPC分类号： C07D251/70 ,  A61K7/42 ,  C07D251/50 ,  C07D251/52

CPC分类号： C07D251/52 ,  A61K8/4966 ,  A61K8/4993 ,  A61Q17/04 ,  C07D251/48 ,  C07D251/50 ,  C07D251/70

摘要： Die vorliegende Erfindung betrifft die nichttherapeutische Verwendung von s-Triazinverbindungen der Formel worin R einen Rest der Formel (1a) X 1 , X 2 und X 3 -SO 2 R 4 ; R 4 verzweigtes oder geradkettiges C 1 -C 22 -Alkyl; C 5 -C 8 -Cycloalkyl; gegebenenfalls mit einem oder mehreren C 1 -C 4 -Alkyl substituiertes C 6 -C 12 -Aryl; gegebenenfalls mit einem oder mehreren C 1 -C 4 -Alkyl substituiertes C 7 -C 10 -Aralkyl; einen Rest der Formel (1b); oder R 2 und R 3 unabhängig voneinander Wasserstoff; geradkettiges oder verzweigtes C 1 -C 22 -Alkyl; C 5 -C 8 -Cycloalkyl; gegebenenfalls mit einem oder mehreren C 1 -C 4 -Alkyl substituiertes C 6 -C 12 -Aryl; gegebenenfalls mit einem oder mehreren C 1 -C 4 -Alkyl substituiertes C 7 -C 10 -Aralkyl; einen Rest der Formel (1b) worin A 1 geradkettiges oder verzweigtes C 1 -C 8 -Alkyl; C 5 -C 8 -Cycloalkyl; gegebenenfalls mit einem oder mehreren C 1 -C 4 -Alkyl substituiertes C 6 -C 12 -Aryl; oder gegebenenfalls mit einem oder mehreren C 1 -C 4 -Alkyl substituiertes C 7 -C 10 -Aralkyl; m 1 1 bis 10; und X 4 , X 5 und X 6 Wasserstoff; oder Hxdroxy; bedeuten, als UV-Filter in Sonnenschutzmitteln.

公开(公告)号：EP1142893A1

公开(公告)日：2001-10-10

申请号：EP01108585.9

申请日：1995-07-31

申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services ,  ARCH DEVELOPMENT CORPORATION ,  THE PENN STATE RESEARCH FOUNDATION, INC.

发明人： Moschel, Robert, C. ,  Pegg, Anthony, E. ,  Dolan, Eilleen, M. ,  Chae, Mi-Young

IPC分类号： C07D473/18 ,  C07D487/04 ,  C07D473/06 ,  C07D473/40 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D251/52 ,  A61K31/52 ,  A61K31/505 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D251/52 ,  C07D473/06 ,  C07D473/18 ,  C07D473/40 ,  C07D487/04 ,  Y10S514/922

摘要： The present invention provides AGT inactivating compounds such as substituted O 6 -benzylguanines, 7- or 9-substituted 8-aza- O 6 -benzylguanines, 7,8-disubstituted O 6 -benzylguanines, 7,9-disubstituted O 6 -benzylguanines, 4(6)-substituted 2-amino-5-nitro-6(4)-benzyloxypyrimidines, and 4(6)-substituted 2-amino-5-nitroso-6(4)-benzyloxypyrimidines, as well as pharmaceutical compositions comprising such compounds along with a pharmaceutically acceptable carrier. The present invention further provides a method of enhancing the chemotherapeutic treatment of tumor cells in a mammal with an antineoplastic alkylating agent which causes cytotoxic lesion at the O 6 -position of guanine, by administering to a mammal an effective amount of one of the aforesaid compounds, 2,4-diamino-6-benzyloxy- s -triazine, 5-substituted 2,4-diamino-6-benzyloxypyrimidines, or 8-aza- O 6 -benzylguanine, and administering to the mammal an effective amount of an antineoplastic alkylating agent which causes cytotoxic lesions of the O 6 -postion of guanine.

摘要翻译： 本发明提供AGT灭活化合物，例如取代的O 6 - 苄基胍，7-或9-取代的8-氮杂-O 6 - 苄基胍，7,8-二取代的O 6 - 苄基胍， 4（6） - 取代的2-氨基-5-硝基-6（4） - 苄氧基嘧啶和4（6） - 取代的2-氨基-5-亚硝基-6（4） - 苄氧基嘧啶 ，以及包含这些化合物以及药学上可接受的载体的药物组合物。 本发明进一步提供了一种增强哺乳动物肿瘤细胞化学治疗的方法，其中抗肿瘤烷化剂通过向哺乳动物施用有效量的一种或多种其中之一，所述抗肿瘤性烷化剂在鸟嘌呤的O 6位上引起细胞毒性损伤 上述化合物，2,4-二氨基-6-苄氧基-s-三嗪，5-取代的2,4-二氨基-6-苄氧基嘧啶或8-氮杂-O 6 - 苄基鸟嘌呤，并向哺乳动物施用有效量 的抗肿瘤性烷化剂，其引起鸟嘌呤的O 6的细胞毒性损伤。