RECOMBINANT ONCOLYTIC NEWCASTLE DISEASE VIRUSES WITH INCREASED ACTIVITY AND IMPROVED VIRAL SAFETY

    公开(公告)号:EP3795161A1

    公开(公告)日:2021-03-24

    申请号:EP19198311.3

    申请日:2019-09-19

    申请人: Thaller, Arno

    发明人: Thaller, Arno

    摘要: The invention relates to transgene expressing Newcastle Disease Viruses (NDV), which have been demonstrated to possess significant oncolytic activity against mammalian cancers and an improved safety profile. The invention provides novel oncolytic viruses through the use of genetic engineering, including the transfer of foreign genes or parts thereof, such as genes encoding Nivolumab, Ipilimumab, IL-12, NS1, Apoptin, or B18R. The present invention also provides nucleic acids encoding a reverse genetically engineered (rg-)NDV comprising one or more of these foreign genes and having a mutation in the HN gene, said mutation allowing replication of said rgNDV in a cancer cell to a higher level than replication of an otherwise identical rgNDV not having said mutation in the HN gene, as well as at least one mutation in the F gene, said mutation resulting in a reduced ICPI value as compared to an otherwise identical rgNDV not having said at least one mutation in the F gene.

    LENS UNIT
    140.
    发明授权

    公开(公告)号:EP3001233B1

    公开(公告)日:2021-01-27

    申请号:EP15184015.4

    申请日:2015-09-07

    发明人: Nakajima, Tomoaki

    IPC分类号: G02B7/02