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公开(公告)号:EP3795161A1
公开(公告)日:2021-03-24
申请号:EP19198311.3
申请日:2019-09-19
申请人: Thaller, Arno
发明人: Thaller, Arno
IPC分类号: A61K35/768 , A61K39/395 , C07K14/125 , C07K16/28 , C12N7/00 , C12N7/02 , C12N15/86
摘要: The invention relates to transgene expressing Newcastle Disease Viruses (NDV), which have been demonstrated to possess significant oncolytic activity against mammalian cancers and an improved safety profile. The invention provides novel oncolytic viruses through the use of genetic engineering, including the transfer of foreign genes or parts thereof, such as genes encoding Nivolumab, Ipilimumab, IL-12, NS1, Apoptin, or B18R. The present invention also provides nucleic acids encoding a reverse genetically engineered (rg-)NDV comprising one or more of these foreign genes and having a mutation in the HN gene, said mutation allowing replication of said rgNDV in a cancer cell to a higher level than replication of an otherwise identical rgNDV not having said mutation in the HN gene, as well as at least one mutation in the F gene, said mutation resulting in a reduced ICPI value as compared to an otherwise identical rgNDV not having said at least one mutation in the F gene.
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公开(公告)号:EP3511439B1
公开(公告)日:2021-03-17
申请号:EP17848472.1
申请日:2017-08-02
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公开(公告)号:EP3583930B1
公开(公告)日:2021-03-03
申请号:EP19185865.3
申请日:2016-10-20
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公开(公告)号:EP3783557A1
公开(公告)日:2021-02-24
申请号:EP18929370.7
申请日:2018-11-06
申请人: SSenStone Inc.
发明人: YOO, Chang Hun
摘要: The virtual code-based financial transaction providing method according to an embodiment of the inventive concept includes a step S200 for receiving a virtual code provided by a virtual code generation means, by a virtual code verification means, a step S400 for extracting multiple detailed codes included in the virtual code by the virtual code verification means, a step S1000 for searching for a storage location of an actual card number on the basis of the multiple detailed codes by the virtual code verification means, and a step S1200 for performing a financial transaction or for making a request for performing a financial transaction with the actual card number extracted from the storage location.
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137.
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公开(公告)号:EP3525350B1
公开(公告)日:2021-02-17
申请号:EP18206239.8
申请日:2018-11-14
发明人: SU, Rina , YAYAMA, Keishi , KUDO, Kazuhiro
IPC分类号: H03K17/965
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公开(公告)号:EP3001233B1
公开(公告)日:2021-01-27
申请号:EP15184015.4
申请日:2015-09-07
发明人: Nakajima, Tomoaki
IPC分类号: G02B7/02
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