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    Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
    15.
    发明公开
    Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols 失效
    选择性由Dialkylzinnoxyden和二醇的加合物的环状蔗糖-6-酰化。

    公开(公告)号：EP0448413A1

    公开(公告)日：1991-09-25

    申请号：EP91302546.6

    申请日：1991-03-22

    申请人： NORAMCO, INC.

    发明人： Walkup, Robert E. ,  Vernon, Nicholas M. ,  Wingard, Robert E., Jr.

    IPC分类号： C07H13/04 ,  C07H13/06 ,  C07H13/08 ,  C07F7/22 ,  C07H23/00

    CPC分类号： C07H13/04 ,  C07F7/2232 ,  C07H13/06 ,  C07H13/08 ,  C07H23/00

    摘要： There is disclosed a process which comprises the steps of:

    (a) reacting a di(hydrocarbyl)tin oxide such as a dialkyltin oxide with a dihydric alcohol, alkanolamine, or an enolizable α-hydroxy ketone in an inert organic reaction vehicle, with removal of water, at a temperature and for a period of time sufficient to produce a cyclic adduct of said dialkyltin oxide and said dihydric alcohol, alkanolamine, or enolizable α-hydroxy ketone;
    (b) reacting said cyclic adduct product of Step (a) with sucrose in an inert organic reaction vehicle such as a dipolar aprotic liquid, at a temperature and for a period of time sufficient to produce a 6-O-[dihydrocarbyl(hydroxy- or amino- or oxohydrocarbyl)stannoxyl]sucrose; and
    (c) reacting the product of Step (b) with an acylating agent to produce a sucrose-6-ester.

    摘要翻译： 有圆盘游离缺失，其包括以下步骤的过程：（a）将二（烃基）氧化锡：如与二元醇的二烷基氧化锡，链烷醇胺，或在惰性有机反应媒介物在烯醇化的α-羟基酮，以去除 的水，在一定温度下一段时间，足以产生所述二烷基氧化锡和Said二元醇，链烷醇胺，或烯醇化的α-羟基酮的环状加成物; （B）反应步骤的所述环状加合物产物的（a）与蔗糖在惰性有机反应媒介物：如偶极非质子液体中，在一定温度下一段时间足以产生6-O- [二烃基（羟基 或氨基 - 或oxohydrocarbyl）stannoxyl]蔗糖; 和（c）在酰化剂以产生蔗糖-6-酯反应步骤（b）用的产物。 Ë

    Improved sucrose-6-ester chlorination
    20.
    发明公开
    Improved sucrose-6-ester chlorination 失效
    Verbessert Chloren von蔗糖-6-酯。

    公开(公告)号：EP0409549A2

    公开(公告)日：1991-01-23

    申请号：EP90307784.0

    申请日：1990-07-17

    申请人： NORAMCO, INC.

    发明人： Walkup, Robert E. ,  Navia, Juan L. ,  Vernon, Nicholas M.

    IPC分类号： C07H13/04 ,  C07H13/08 ,  C07H5/02

    CPC分类号： C07H5/02

    摘要： A process for the chlorination of sucrose-6-esters to produce 6′,4,1′-trichlorosucrose-6-esters which comprises the steps of:

    (a) adding at least seven molar equivalents of an acid chloride to a reaction mixture containing a sucrose-6-ester and a tertiary amide to form initially a chloroformiminium chloride salt which subsequently forms a complex with the hydroxyl goups of the sucrose-6-ester;
    (b) subjecting the reaction mixture product of step (a) to an elevated temperature not higher than about 85°C for a period of time sufficient to produce a mixture of chlorinated sucrose-6-ester products consisting essentially of 6′-chlorosucrose-6-ester, 4,6′-dichloro­sucrose-6-ester, and 1′,6′-dichlorosucrose-6-ester; and
    (c) subjecting the reaction mixture product of step (b) to an elevated temperature not higher than about 125°C for a period of time sufficient to produce a chlorinated product consisting essentially of 1′,4,6′-trichlorosucrose-­6-ester.

    摘要翻译： 蔗糖-6-酯氯化制备6分钟四氯蔗糖-6-酯的方法，其包括以下步骤：（a）将至少7摩尔当量的酰氯加入到含有 蔗糖-6-酯和叔酰胺，以最初形成氯甲酰亚胺氯化铵盐，其随后与蔗糖-6-酯的羟基化合物形成络合物; （b）使步骤（a）的反应混合物产物在不高于约85℃的升高温度下持续足以产生氯化蔗糖-6-酯产物混合物的时间，该产物基本上由6分钟 - 氯代蔗糖 - 6分钟，4,6分钟 - 二氯蔗糖-6-酯和1分钟，6分钟 - 二氯蔗糖-6-酯; 和（c）将步骤（b）的反应混合物产物在不高于约125℃的升高温度下进行一段足以产生基本上由1分钟，4,6分钟三氯蔗糖-6 -酯。