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公开(公告)号：EP2835429B1
公开(公告)日：2017-12-13
申请号：EP14173646.2
申请日：2007-05-10
发明人： Tan, Pamela , Bramlage, Birgit , Frank-Kamenetsky, Maria , Fitzgerald, Kevin , Akinc, Akin , Kotelianski, Victor E.
IPC分类号： C12Q1/68 , A01N43/04 , C07H21/04 , A61K31/07 , C12N15/113
CPC分类号： C12N15/1137 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3515 , C12N2310/3521
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公开(公告)号：EP2194128B1
公开(公告)日：2012-08-01
申请号：EP09015323.0
申请日：2007-05-10
发明人： Tan, Pamela , Bramlage, Birgit , Frank-Kamenetsky, Maria , Fitzgerald, Kevin , Akinc, Akin , Kotelianski, Victor, E.
CPC分类号： C12N15/1137 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human PCSK9 gene in a cell, wherein said dsRNA comprises at least two sequences that are complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence comprising a region of complementarity which is substantially complementary to at least a part of a mRNA encoding PCSK9, and wherein said region of complementarity is less than 30 nucleotides in length and wherein said dsRNA, upon contact with a cell expressing said PCSK9, inhibits expression of said PCSK9 gene, wherein (a) said first sequence is the sequence of SEQ ID NO: 1229 and said second sequence is the sequence of SEQ ID NO: 1230; (b) said first sequence is the sequence of SEQ ID NO: 1227 and said second sequence is the sequence of SEQ ID NO: 1228; or (c) said part of said mRNA encoding PCSK9 is the sequence from position 3530 to 3548 of the mRNA sequence of database entry NM_174936.
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