公开(公告)号：EP4141095A1

公开(公告)日：2023-03-01

申请号：EP21306143.5

申请日：2021-08-25

申请人： Sartorius Stedim FMT SAS ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Institut National des Sciences Appliquées de Lyon ,  Ecole Superieure de Chimie Physique Electronique de Lyon ,  Le Centre National de la Recherche Scientifique

发明人： CHASTAGNIER, Laura ,  PETIOT, Emma ,  COURTIAL, Edwin Geoffrey ,  MARQUETTE, Christophe

IPC分类号： C12M1/12 ,  C12M1/26 ,  B33Y70/10

摘要： Methods and systems for performing a bioproduction process are described, the bioproduction process comprising the production of a cellular product by a cell population. The methods include the steps of culturing the cell population at least partially embedded in a hydrogel matrix forming a three-dimensional structure.

公开(公告)号：EP1723431B1

公开(公告)日：2012-09-05

申请号：EP05733006.0

申请日：2005-03-02

申请人： Université Claude Bernard Lyon I ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Institut National des Sciences Appliquées de Lyon

发明人： PERRIAT, Pascal ,  LOUIS, Cédric ,  MARQUETTE, Christophe ,  BAZZI, Rana ,  ROUX, Stéphane ,  TILLEMENT, Olivier ,  LEDOUX, Gilles

IPC分类号： G01N33/543 ,  G01N33/58 ,  G01N33/533 ,  G01N33/52 ,  G01N33/553 ,  A61K41/00 ,  A61K49/00 ,  A61K49/18 ,  C01F17/00 ,  B82Y30/00 ,  B82Y5/00 ,  C08L83/04 ,  A61K47/00

CPC分类号： G01N33/54346 ,  A61K41/009 ,  A61K49/0002 ,  A61K49/0093 ,  A61K49/1848 ,  A61K49/1857 ,  B82Y5/00 ,  B82Y30/00 ,  C01F17/0043 ,  C01P2002/52 ,  C01P2004/64 ,  G01N33/54353

公开(公告)号：EP4361944A1

公开(公告)日：2024-05-01

申请号：EP22306652.3

申请日：2022-10-31

申请人： Sartorius Stedim Data Analytics AB ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Institut National des Sciences Appliquées de Lyon ,  Ecole Superieure de Chimie Physique Electronique de Lyon ,  Centre national de la recherche scientifique

发明人： SJÖGREN, Rickard ,  REIF, Oscar-Werner ,  TRYGG, Johan ,  PETIOT, Emma ,  MARQUETTE, Christophe ,  CHASTAGNIER, Laura

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  G06T2207/1005620130101 ,  G06T2207/1008820130101 ,  G06T2207/2007620130101 ,  G06T2207/2008420130101 ,  G06T2207/3002420130101 ,  G06T2207/1006420130101

摘要： Methods for monitoring a process for producing multicellular structures from a cell population in a 3D cell culture are described. The methods comprise obtaining one or more 3D images of the 3D cell culture that are acquired by imaging the cell culture at different depths and/or from different angles, processing the one or more images to obtain a plurality of image-derived features, and determining the value of one or more metrics indicative of the progress or outcome of the maturation process using a statistical model adapted to predict the values of the one or more metrics indicative of the progress or outcome of the maturation process using inputs comprising the plurality of image-derived features. Related methods, systems and products are also described.

公开(公告)号：EP4392539A1

公开(公告)日：2024-07-03

申请号：EP22768776.1

申请日：2022-08-23

申请人： SARTORIUS STEDIM FMT SAS ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Institut National des Sciences Appliquées de Lyon ,  Ecole Superieure de Chimie, Physique, Electronique de Lyon ,  Centre National de la Recherche Scientifique

发明人： CHASTAGNIER, Laura ,  PETIOT, Emma ,  COURTIAL, Edwin Geoffrey ,  MARQUETTE, Christophe

IPC分类号： C12M1/12 ,  C12M1/26 ,  B33Y70/10

CPC分类号： C12M25/14 ,  C12M33/00 ,  B33Y70/00 ,  B33Y80/00 ,  B29C64/106 ,  B33Y10/00

公开(公告)号：EP1723431A1

公开(公告)日：2006-11-22

申请号：EP05733006.0

申请日：2005-03-02

申请人： Université Claude Bernard Lyon ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Institut National des Sciences Appliquées de Lyon

发明人： PERRIAT, Pascal ,  LOUIS, Cédric ,  MARQUETTE, Christophe ,  BAZZI, Rana ,  ROUX, Stéphane ,  TILLEMENT, Olivier ,  LEDOUX, Gilles

IPC分类号： G01N33/58 ,  G01N33/533 ,  G01N33/52 ,  G01N33/553

CPC分类号： G01N33/54346 ,  A61K41/009 ,  A61K49/0002 ,  A61K49/0093 ,  A61K49/1848 ,  A61K49/1857 ,  B82Y5/00 ,  B82Y30/00 ,  C01F17/0043 ,  C01P2002/52 ,  C01P2004/64 ,  G01N33/54353

摘要： Hybrid nanoparticles including a nanosphere with a mean diameter in the range 2-9 nm, of which at least 90 wt % consists of Ln2O3, where Ln is a rare earth optionally doped with a rare earth or an actinide, or a mixture of rare earths, or else a rare earth/actinide mixture in which at least 50 % of the metal ions are rare-earth ions; a coating around the nanosphere, of which a major part consists of a functionalised polysiloxane, and which has a mean thickness in the range 0.5-10 nm, preferably more than 2 nm but no more than 10 nm; and at least one bioligand grafted by a covalent bond to the polysiloxane coating; and a method for preparing same.