公开(公告)号：EP1784400B1

公开(公告)日：2015-01-14

申请号：EP05789881.9

申请日：2005-08-15

申请人： ELI LILLY AND COMPANY

发明人： FINLEY, Don, Richard ,  FINN, Terry, Patrick ,  HIPSKIND, Philip, Arthur ,  HORNBACK, William, Joseph ,  JESUDASON, Cynthia, Darshini ,  TAKAKUWA, Takako

IPC分类号： C07D409/10 ,  C07D413/14 ,  C07D409/14 ,  C07D417/10 ,  C07D405/10 ,  C07D403/10 ,  C07D401/14 ,  C07D417/14 ,  A61K31/4025 ,  A61P25/00

CPC分类号： C07D207/327 ,  C07D401/14 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D409/14 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14

公开(公告)号：EP1868991B1

公开(公告)日：2014-07-30

申请号：EP06758217.1

申请日：2006-03-28

申请人： ELI LILLY AND COMPANY

发明人： HIPSKIND, Philip, Arthur ,  TAKAKUWA, Takako ,  JESUDASON, Cynthia, Darshini ,  GADSKI, Robert, Alan ,  HORNBACK, William, Joseph ,  PICKARD, Richard, Todd ,  BEAVERS, Lisa, Selsam

IPC分类号： C07D207/09 ,  C07D401/06 ,  A61K31/4025 ,  A61P3/04

CPC分类号： C07D207/09 ,  C07D401/06

公开(公告)号：EP1904442B1

公开(公告)日：2011-09-07

申请号：EP06774260.1

申请日：2006-06-28

申请人： ELI LILLY AND COMPANY

发明人： BEAVERS, Lisa, Selsam ,  FINLEY, Don, Richard ,  GADSKI, Robert, Alan ,  HIPSKIND, Philip, Arthur ,  HORNBACK, William, Joseph ,  JESUDASON, Cynthia, Darshini ,  PICKARD, Richard, Todd ,  TAKAKUWA, Takako ,  VAUGHT, Grant, Mathews

IPC分类号： C07D207/09 ,  C07D403/12 ,  C07D401/12 ,  A61K31/4025 ,  A61P3/04 ,  A61P25/28

CPC分类号： C07D207/09 ,  C07D401/12 ,  C07D403/12

摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I)

公开(公告)号：EP2094709B1

公开(公告)日：2010-09-15

申请号：EP07842582.4

申请日：2007-09-17

申请人： ELI LILLY AND COMPANY

发明人： CHEN, Zhaogen ,  HAMDOUCHI, Chafiq, Hamdouchi ,  HEMBRE, Erik, James ,  HIPSKIND, Philip, Arthur ,  MYERS, Jason, Kenneth ,  TAKAKUWA, Takako ,  TOTH, James, Lee

IPC分类号： C07D487/04 ,  A61K31/505 ,  A61P29/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.

摘要翻译： 本发明涉及式（I）化合物，其药物组合物及其作为促肾上腺皮质素释放因子1（CRF1）受体拮抗剂在治疗精神病和神经内分泌疾病，神经疾病和代谢综合征中的用途。

公开(公告)号：EP1735278B1

公开(公告)日：2010-01-06

申请号：EP05730691.2

申请日：2005-03-25

申请人： ELI LILLY AND COMPANY

发明人： BEAVERS, Lisa, Selsam ,  FINLEY, Don, Richard ,  FINN, Terry, Patrick Eli Lilly and Company ,  GADSKI, Robert, Alan ,  HIPSKIND, Philip, Arthur ,  HORNBACK, William, Joseph ,  JESUDASON, Cynthia, Darshini ,  PICKARD, Richard, Todd ,  TAKAKUWA, Takako ,  VAUGHT, Grant, Mathews

IPC分类号： C07D207/09 ,  C07D401/10 ,  C07D413/10 ,  C07D403/10 ,  C07D405/10 ,  A61K31/00 ,  A61K31/4025 ,  A61P25/00 ,  A61P3/04

CPC分类号： C07D207/09 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D413/10 ,  C07D471/04

摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases

公开(公告)号：EP1869049B1

公开(公告)日：2009-03-04

申请号：EP06738924.7

申请日：2006-03-20

申请人： ELI LILLY AND COMPANY

发明人： BARBOSA, Heather, Janelle ,  COLLINS, Elizabeth, Aaron ,  HAMDOUCHI, Chafiq ,  HEMBRE, Erik, James ,  HIPSKIND, Philip, Arthur ,  JOHNSTON, Richard, Duane ,  LU, Jianliang ,  RUPP, Michael, John ,  TAKAKUWA, Takako ,  THOMPSON, Richard, Craig

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P25/20

CPC分类号： C07D487/04

摘要： The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.