公开(公告)号：EP2160372A1

公开(公告)日：2010-03-10

申请号：EP08762874.9

申请日：2008-06-13

申请人： Medichem, S.A.

发明人： SOLDEVILLA MADRID, Nuria ,  BOSCH I LLADO, Jordi

IPC分类号： C07B57/00 ,  B01D15/38 ,  G01N30/68

CPC分类号： G01N30/88 ,  B01D15/3833 ,  G01N30/02 ,  G01N2030/884 ,  G01N2030/8877

摘要： The present invention relates to a method for differentiating and quantifying the enantiomers, thereby determining the enantiomeric purity, of darifenacin and its intermediate compounds and salts thereof. In addition, the invention relates to a method for differentiating and quantifying the enantiomers, thereby determining the enantiomeric purity of compounds of formula (I): wherein Y is hydrogen or a substituent of the formula (II): including the differentiation and quantification of compounds of formula (I) of varying enantiomeric purity from their corresponding enantiomers. The invention further relates to a process for preparing enantiomerically pure darifenacin using enantiomerically pure starting compounds which have been previously differentiated and quantified according to the method of the invention.

公开(公告)号：EP1971573A2

公开(公告)日：2008-09-24

申请号：EP06850451.3

申请日：2006-12-22

申请人： Medichem S.A.

发明人： GAVALDA I ESCUDE, Ana ,  BOSCH I LLADO, Jordi ,  VIDAL I FERRAN, Anton ,  GARCIA GARCIA, Eva

IPC分类号： C07D205/08 ,  C07D263/24

CPC分类号： C07D205/08

摘要： The invention relates, in general, to an improved process for the preparation of the compounds (3R,4S)-4-(4-(benzyloxy)phenyl)-l-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3- oxopropyl]azetidin-2-one and (3R,4S)-l-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]- 4-(4-hydroxyphenyl)-azetidin-2-one, which are key intermediates for the synthesis of ezetimibe, as well as the use of these intermediates for the preparation of ezetimibe.

公开(公告)号：EP1885727A2

公开(公告)日：2008-02-13

申请号：EP06809025.7

申请日：2006-05-03

申请人： Medichem, S.A.

发明人： TOJO SUAREZ, Gabriel ,  DURAN LOPEZ, Ernesto ,  BOSCH I LLADO, Jordi

IPC分类号： C07D491/10

CPC分类号： C07D491/10

摘要： The present invention relates to a process for preparing racemic narwedine (which can be can be kinetically resolved to yield (-)-narwedine and which is the biogenic precursor of (-)- galanthamine) and the use thereof as a starting material for producing (-)-galanthamine. The invention further includes processes for preparing (-)-galanthamine and (-)-galanthamine hydrobromide, as well as related novel compounds.

公开(公告)号：EP1426356A1

公开(公告)日：2004-06-09

申请号：EP01969812.5

申请日：2001-09-14

申请人： Medichem S.A.

发明人： BOSCH I LLADO, Jordi ,  CAMPS GARCIA, Pelayo ,  CONTRERAS LASCORZ, Juan ,  ONRUBIA MIGUEL, Ma Carmen

IPC分类号： C07C233/11 ,  C07C231/02 ,  C07D241/04

CPC分类号： C07C237/22 ,  C07D241/04

摘要： Intermediate compounds for the preparation of mirtazapine and obtention methods thereof. A method is described for obtaining (±)-3-phenyl-1-methylpiperazine, an important intermediate for obtaining mirtazapine, which is based on imposing a cyclation reaction, in the presence of a reducing agent, on new compounds of general formula (I)
in which Z is a leaving group capable of undergoing a nucleophylic displacement. A method is also described for obtaining the new compounds of formula (I).

摘要翻译： 用于它们的米尔塔扎平和获得方法的方法制备的中间体化合物。 描述了一种方法，用于获得（+/-） - 3-苯基-1-甲基哌嗪，以重要中间体用于获得米氮平，所有这是基于强加环化反应，在还原剂的存在下，对通式的新化合物 （I）其中Z是能够进行亲核置换的离去基团。 因此一种方法是描述用于获得式（I）的新化合物。