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15 条记录 (耗时 0.013 秒)

    SPECIFIC MONOCLONAL ANTIBODY AGAINST TERBINAFINE
    14.
    发明公开
    SPECIFIC MONOCLONAL ANTIBODY AGAINST TERBINAFINE 有权
    特异性单克隆抗体反对特比萘芬

    公开(公告)号：EP1261874A1

    公开(公告)日：2002-12-04

    申请号：EP01907523.3

    申请日：2001-02-12

    申请人： Novartis AG ,  Novartis Erfindungen Verwaltungsgesellschaft M.B.H.

    发明人： DOROBEK, Birgit ,  NUSSBAUMER, Peter

    IPC分类号： G01N33/577 ,  G01N33/53 ,  A61K47/48 ,  C07K16/44 ,  C12N5/20

    CPC分类号： C07K16/44 ,  A61K47/643 ,  A61K47/646

    摘要： The invention concerns monoclonal antibodies to terbinafine in free base or salt form, immunogenic conjugates suitable for preparing them, hybridoma capable of producing them, and corresponding assay kits. The antibodies can be prepared by administering to an appropriate animal an immunogenic conjugate of a suitable derivative of terbinafine covalently linked to an immunogen, recovering antibody-producing cells sensitized to the conjugate, immortalizing the antibody-producing cells, selecting a resultant immortalized cell line, and recovering the resultant antibodies therefrom. They are indicated for use in particular in the measurement of terbinafine tissue concentration and distribution in bodily fluids or compartments, especially nails.

    CHROMANONE AND THIOCHROMANONE DERIVATIVES
    15.
    发明公开
    CHROMANONE AND THIOCHROMANONE DERIVATIVES 有权
    吡喃酮和苯并二氢噻喃衍生物

    公开(公告)号：EP1070059A1

    公开(公告)日：2001-01-24

    申请号：EP99917963.3

    申请日：1999-04-07

    申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

    发明人： BILLICH, Andreas ,  NUSSBAUMER, Peter ,  SCHREINER, Erwin ,  SCHUSTER, Ingeborg

    IPC分类号： C07D311/22 ,  C07D335/06 ,  A61K31/35

    CPC分类号： C07D335/06 ,  C07D311/22

    摘要： The invention concerns compounds of formula (I), wherein R1 and R2 independently are hydrogen, acyl, alkoxycarbonyl or alkyl; either the sulfamoyloxy side chain is bound to the 6 position; R3 is alkyl; alkenyl; alkinyl; a cycloalkyl moiety optionally substituted by alkyl, alkoxy or halogen; arylalkyl; arylalkenyl; arylalkinyl; acyl; cycloalkylalkyl; 3-oxo-2-oxacamphanyl; 6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl; a heteroaryl moiety optionally substituted by alkyl, alkoxy or halogen; or is heteroarylalkyl; and R4 is hydrogen; alkyl; hydroxy; or alkoxy; or the sulfamoyloxy side chain is bound to the 7 position; R3 has the significance indicated above for R4; and R4 has the significance indicated above for R3; X is O or S; and the symbol --- is a single or a double bond; in free form or salt form. They can be prepared by sulfamoylation of corresponding hydroxylated compounds, by reduction and/or by N-substitution. They are indicated for use as pharmaceuticals, particularly in the prophylactic or curative treatment of illnesses responsive to steroid sulfatase inhibition.