公开(公告)号：EP4218777A3

公开(公告)日：2023-08-23

申请号：EP23150498.6

申请日：2016-08-25

申请人： The Trustees of the University of Pennsylvania ,  Wayne State University

发明人： JUNE, Carl H. ,  MILONE, Michael ,  ZHAO, Yangbing ,  LUM, Lawrence G. ,  THAKUR, Archana

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K19/00 ,  C12N5/0783 ,  C12N15/62

摘要： The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an intracellular signaling molecule in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.

公开(公告)号：EP4218777A2

公开(公告)日：2023-08-02

申请号：EP23150498.6

申请日：2016-08-25

申请人： The Trustees of the University of Pennsylvania ,  Wayne State University

发明人： JUNE, Carl H. ,  MILONE, Michael ,  ZHAO, Yangbing ,  LUM, Lawrence G. ,  THAKUR, Archana

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K19/00 ,  C12N5/0783 ,  C12N15/62

摘要： The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an intracellular signaling molecule in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.

公开(公告)号：EP3340998A1

公开(公告)日：2018-07-04

申请号：EP16842639.3

申请日：2016-08-25

申请人： The Trustees of The University of Pennsylvania ,  Wayne State University

发明人： JUNE, Carl H. ,  MILONE, Michael ,  ZHAO, Yangbing ,  LUM, Lawrence ,  THAKUR, Archana

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K19/00 ,  C12N5/0783 ,  C12N15/62

CPC分类号： C12N5/0636 ,  A61K35/17 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/30 ,  C12N2510/00

摘要： The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an intracellular signaling molecule in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.

公开(公告)号：EP3952885A1

公开(公告)日：2022-02-16

申请号：EP20787846.3

申请日：2020-04-11

申请人： The Trustees of The University of Pennsylvania

发明人： O'ROURKE, Donald ,  BINDER, Zev ,  MILONE, Michael ,  THOKALA, Radhika

IPC分类号： A61K35/12 ,  A61K35/17 ,  A61K35/763 ,  A61K39/00