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公开(公告)号：EP2646076A1
公开(公告)日：2013-10-09
申请号：EP11788159.9
申请日：2011-11-28
发明人： LEAK, David Martin , BOYD, Malcolm Stanley , DE SAUSMAREZ LINTELL, Daniel Thomas , BILTON, Simon Lewis , HIGGINS, Daniel David
CPC分类号： A61M5/31548 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/31525 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/3157 , A61M5/31585 , A61M5/31593 , A61M2005/202
摘要： A drug delivery device having a spring element (216) that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism (202), a fixed dose setting mechanism (104), and a mechanical coupling having a spring element. The variable dose setting mechanism is operably coupled to a first reservoir (6) holding a first medicament (1), and the variable dose setting mechanism comprises a dose setter (208). The fixed dose setting mechanism is operably coupled to a second reservoir (5) holding a second medicament. The mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter, and the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during variable dose setting. Still further, the spring element is configured to store energy during dose setting and to transfer stored energy to the fixed dose setting mechanism to assist with dispense of the fixed dose. 10/236WO
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公开(公告)号：EP2627379A1
公开(公告)日：2013-08-21
申请号：EP11767701.3
申请日：2011-10-11
发明人： LEAK, David Martin , BUTLER, Joseph
IPC分类号： A61M5/315
CPC分类号： A61M5/31528 , A61M5/31525 , A61M5/31538 , A61M5/31551 , A61M5/31571 , A61M5/31585
摘要： The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.
摘要翻译： 本发明涉及药物输送装置的剂量设定机构及其使用方法。 所述机构包括药物输送装置壳体，剂量拨号套筒，其至少部分地定位在所述壳体中并且在剂量设定和剂量递送期间可旋转;在剂量设定期间可旋转的离合器以及剂量递送期间不可旋转的离合器螺母， 与离合器螺纹接合并且花键连接到壳体以防止离合器螺母的旋转。
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公开(公告)号：EP2627376A1
公开(公告)日：2013-08-21
申请号：EP11767444.0
申请日：2011-10-11
IPC分类号： A61M5/315
摘要： A dose setting mechanism for a drug delivery device. The mechanism may comprise a drug delivery device housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A split threaded insert is in threaded engagement with the dose dial component. The insert can transform from a first configuration to a second configuration when the dose dial component is rotated. In one dose setting mechanism arrangement, the first configuration may comprise a first open configuration and the second configuration may comprise a second closed configuration.
摘要翻译： 一种用于药物输送装置（100; 200）的剂量设定机构。 该机构可以包括药物输送装置壳体（220）。 剂量刻度部件（222）定位在壳体中并且在剂量设定和剂量输送期间可旋转。 开口螺纹插入件（201）与剂量拨盘部件（222）螺纹接合。 当剂量刻度盘部件旋转时，插入件可以从第一构型转变为第二构型。 在一个剂量设定机构布置中，第一配置可以包括第一打开配置并且第二配置可以包括第二关闭配置。
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公开(公告)号：EP3626286A1
公开(公告)日：2020-03-25
申请号：EP19202600.3
申请日：2010-11-29
发明人： DAY, Shane Alistair , DE SAUSMAREZ LINTELL, Daniel Thomas , WIMPENNY, Steven , JONES, Christopher , O'HARE, Aidan Michael , YATES, Barry , VEASEY, Robert , SMITH, Christopher James , BOYD, Malcolm , LEAK, David Martin , KEATING, Carmen Patricia , SANDERS, David , MARSHALL, Elizabeth Anne
摘要： A drug delivery device comprising:
a motor (530) configured to advance a stopper in a cartridge of medicament, the motor comprising an output shaft;
a controller; and
a motion detection system (522) configured to provide positional feedback to the controller, wherein the motion detection system comprises an optical encoder (534) and at least one element (528) operatively coupled to the output shaft (531) of the motor and configured to rotate with the output shaft such that the at least one element passes through the optical encoder.-
公开(公告)号：EP2627376B1
公开(公告)日：2019-11-20
申请号：EP11767444.0
申请日：2011-10-11
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16.发明公开DRUG DELIVERY DEVICE AND METHOD FOR SEQUENTIALLY DELIVERING AT LEAST TWO MEDICAMENTS 审中-公开DEVICE药物释放至少两种药物的连续给药
公开(公告)号：EP2646081A1
公开(公告)日：2013-10-09
申请号：EP11791261.8
申请日：2011-11-28
发明人： KEATING, Carmen Patricia , BOYD, Malcolm Stanley , LEAK, David Martin , SANDERS, David , MARSHALL, Elizabeth Anne , PLUMPTRE, David Aubrey
IPC分类号： A61M5/19
CPC分类号： A61M5/19 , A61M5/31548
摘要： Various examples of a drug delivery device and corresponding method for sequentially delivering at least two medicaments via a single dispense interface are provided. In one example, the device includes a variable dose setting mechanism operably connected to a first cartridge containing a first medicament, a fixed dose setting mechanism operably connected to a second cartridge containing a second medicament, a dose setter for setting a user settable dose of the first medicament and a fixed dose of the second medicament, and a connecting feature for detachably connecting the variable dose setting mechanism to the fixed dose setting mechanism. During setting of the fixed dose of the second medicament, the rotationally driven variable dose setting mechanism and the fixed dose setting mechanism are connected via the connecting feature, however, during setting of the user settable dose of the first medicament, the rotationally driven variable dose setting mechanism and the fixed dose setting mechanism are not connected.
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公开(公告)号：EP2646078A1
公开(公告)日：2013-10-09
申请号：EP11788173.0
申请日：2011-11-28
发明人： SMITH, Christopher James , KEATING, Carmen Patricia , LEAK, David Martin , BOYD, Malcolm Stanley
CPC分类号： A61M5/31545 , A61M5/19 , A61M5/24 , A61M5/3155 , A61M5/31565 , A61M2005/1787
摘要： A drug delivery device having a dose limiting system. The drug delivery device includes a first dose setting mechanism (205) operably coupled to a primary reservoir (212) holding a first medicament (214). The first dose setting mechanism includes a first dose setter (208) and is a variable dose setting mechanism. The device further includes a second dose setting mechanism (204) operably coupled to a secondary reservoir (216) holding a second medicament, and the second dose setting mechanism includes a second dose setter (230). Still further, the device includes a dose limiting system (206). The dose limiting system operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the dose limiting system is configured to limit a settable amount of a dose of the second medicament a user can set using the second dose setter based on an amount of a variable dose that a user sets using the first dose setter.
摘要翻译： 具有剂量限制系统的药物输送装置。 药物输送装置包括第一剂量设定机构（205），该第一剂量设定机构（205）可操作地联接到保持第一药剂（214）的主储存器（212）。 第一剂量设定机构包括第一剂量设定器（208）并且是可变剂量设定机构。 该装置还包括可操作地联接至容纳第二药剂的第二储存器（216）的第二剂量设定机构（204），并且第二剂量设定机构包括第二剂量设定器（230）。 更进一步地，该装置包括剂量限制系统（206）。 剂量限制系统可操作地连接可变剂量设定机构和固定剂量设定机构。 此外，剂量限制系统被配置为基于用户使用第一剂量设定器设定的可变剂量的量来限制使用者可使用第二剂量设定器设定的第二药剂的可设定量的剂量。
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公开(公告)号：EP2646077A1
公开(公告)日：2013-10-09
申请号：EP11788166.4
申请日：2011-11-28
发明人： HOLTWICK, Marc , CERMAN, Zdenek , LEAK, David Martin , BOYD, Malcolm Stanley , DE SAUSMAREZ LINTELL, Daniel Thomas , SANDERS, David
CPC分类号： A61M5/19 , A61M5/14244 , A61M5/1452 , A61M5/16827 , A61M5/20 , A61M5/2066 , A61M2005/2407 , A61M2005/247 , A61M2005/2496 , A61M2005/3125 , A61M2005/3126 , A61M2005/3128 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/6072 , A61M2205/8206
摘要： A dispense interface component for use with a drug delivery device is provided. The dispense interface component may include a main body (14), a first piercing portion (1208), a second piercing portion (1212), and a biasing element. The main body is configured for connection to the drug delivery device. The first piercing portion is for piercing a first cartridge (1210) contained within the drug delivery device, and the first piercing portion is connected to the main body. The second piercing portion is for piercing a second cartridge (1214) contained with the drug delivery device, and the second piercing portion is connected to the main body. The at least one biasing element (1216) is operably coupled to the main body, wherein the at least one biasing element is configured to, when the load on the at least one biasing element is less than or equal to a threshold load, bias (i) the first piercing portion away from the first cartridge and (ii) the second piercing portion away from the second cartridge.
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19.发明公开
公开(公告)号：EP2506896A1
公开(公告)日：2012-10-10
申请号：EP10787080.0
申请日：2010-11-29
发明人： DAY, Shane Alistair , DE SAUSMAREZ LINTELL, Daniel Thomas , WIMPENNY, Steven , JONES, Christopher , O'HARE, Aidan Michael , YATES, Barry , VEASEY, Robert , SMITH, Christopher James , BOYD, Malcolm , LEAK, David Martin , KEATING, Carmen Patricia , SANDERS, David , MARSHALL, Elizabeth Anne
CPC分类号： A61M5/19 , A61M5/14244 , A61M5/14248 , A61M5/1723 , A61M5/20 , A61M5/24 , A61M5/31511 , A61M5/31525 , A61M5/31546 , A61M5/31583 , A61M5/3202 , A61M5/3294 , A61M5/3295 , A61M5/347 , A61M2005/2407 , A61M2005/2411 , A61M2005/2496 , A61M2005/3126 , A61M2005/31518 , A61M2005/31588 , A61M2205/14 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/6063 , A61M2205/6072 , A61M2205/8206
摘要： A computerized electro-mechanical drug delivery device (10) configured to deliver at least one dose of two or more medicaments. The device comprises a control unit (300). An electro-mechanical drive unit (500, 600) is operably coupled to the control unit and a primary reservoir (90) for a first medicament and a secondary reservoir (100) for a fluid agent, e.g. a second medicament. An operator interface (60) is in communication with the control unit (300). A single dispense assembly (200) is configured for fluid communication with the primary (90) and the secondary (100) reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile (860), the control unit (300) is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament.
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