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21 条记录 (耗时 0.016 秒)

    Novel quinoline derivates and processes for preparation thereof
    12.
    发明公开
    Novel quinoline derivates and processes for preparation thereof 失效
    Chinolinderivate和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0242789A2

    公开(公告)日：1987-10-28

    申请号：EP87105602.4

    申请日：1987-04-15

    申请人： Dainippon Pharmaceutical Co., Ltd.

    发明人： Matsumoto, Jun-ichi ,  Miyamoto, Teruyuki ,  Egawa, Hiroshi ,  Nakamura, Shinichi

    IPC分类号： C07D215/56 ,  C07D401/04 ,  A61K31/47 ,  A61K31/495

    CPC分类号： C07D215/56 ,  C07D401/04

    摘要： The present invention relates to quinoline derivatives of the formula
    wherein Z is an amino group or a halogen atom,

    in which R 1 is a hydrogen atom, a lower alkyl or haloalkyl group, R 2 is a hydrogen atom or a lower alkyl group, R 3 is a lower alkyl or haloalkyl group, R 4 is a hydrogen atom or a lower alkyl group, R 5 and R 6 are the same or different and each represents a hydrogen atom or a lower alkyl group, or R 5 and R s , together with the nitrogen atom to which they are attached, form a heterocyclic ring, and n is 0 or 1, with the proviso that when Z is an amino group R is (B);
    and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent ant- bacterial activity and are useful antibacterial agents.

    摘要翻译： 本发明涉及其中Z为氨基或卤素原子的式CHEM的喹啉衍生物，其中R 1为氢原子，低级烷基或卤代烷基，R 2为氢原子或低级 烷基，R3是低级烷基或卤代烷基，R4是氢原子或低级烷基，R5和R6相同或不同，各自表示氢原子或低级烷基，或R5和R6连同 它们所连接的氮原子形成杂环，n为0或1，条件是当Z为氨基时，R为（B）; 及其酯及其盐及其制备方法。 这些化合物显示出优异的抗细菌活性，并且是有用的抗菌剂。

    Novel quinoline derivates and processes for preparation thereof
    13.
    发明公开
    Novel quinoline derivates and processes for preparation thereof 失效
    新型喹啉衍生物及其制备方法

    公开(公告)号：EP0242789A3

    公开(公告)日：1990-09-05

    申请号：EP87105602.4

    申请日：1987-04-15

    申请人： Dainippon Pharmaceutical Co., Ltd.

    发明人： Matsumoto, Jun-ichi ,  Miyamoto, Teruyuki ,  Egawa, Hiroshi ,  Nakamura, Shinichi

    IPC分类号： C07D215/56 ,  C07D401/04 ,  A61K31/47 ,  A61K31/495

    CPC分类号： C07D215/56 ,  C07D401/04

    摘要： The present invention relates to quinoline derivatives of the formula
    wherein Z is an amino group or a halogen atom,
    in which R 1 is a hydrogen atom, a lower alkyl or haloalkyl group, R 2 is a hydrogen atom or a lower alkyl group, R 3 is a lower alkyl or haloalkyl group, R 4 is a hydrogen atom or a lower alkyl group, R 5 and R 6 are the same or different and each represents a hydrogen atom or a lower alkyl group, or R 5 and R s , together with the nitrogen atom to which they are attached, form a heterocyclic ring, and n is 0 or 1, with the proviso that when Z is an amino group R is (B); and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent ant- bacterial activity and are useful antibacterial agents.

    Prevention or elimination of mycoplasma contamination of animal or plant cell culture
    15.
    发明公开
    Prevention or elimination of mycoplasma contamination of animal or plant cell culture 失效
    预防或植物或动物细胞培养支原体污染的消除。

    公开(公告)号：EP0348947A2

    公开(公告)日：1990-01-03

    申请号：EP89111783.0

    申请日：1989-06-28

    申请人： DAINIPPON PHARMACEUTICAL CO., LTD.

    发明人： Nakamura, Shinichi ,  Sakaguchi, Yuzo ,  Kashimoto, Shigeki ,  Matsumoto, Jun-ichi

    IPC分类号： C12N5/00

    CPC分类号： C12N5/00

    摘要： A method of preventing or eliminating myco­plasma contamination of animal or plant cell cultures, which comprises adding an anti-mycoplasmally effective amount of 5-amino-7-(2-aminomethylmorpholino)-1-cyclo­propyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-­carboxylic acid or its salt to a culture medium in which animal or plant cells are cultivated; and an agent or a preparation for preventing or eliminating mycoplasma contamination of animal or plant cell cultures, com­prising 5-amino-7-(2-aminomethylmorpholino)-1-cyclo­propyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-­carboxylic acid or its salt.

    摘要翻译： 防止或消除动物或植物细胞培养物的支原体污染的方法，包括加入抗mycoplasmally有效量的5-氨基-7-（2- aminomethylmorpholino）-1-环丙基-6,8-二氟-1,4-中的的方法 -dih氢 - 4-氧代喹啉-3-羧酸或其盐，其中动物或植物中培养细胞的培养基中; 植物和试剂或用于防止或消除动物或细胞培养物的支原体污染，包括制备5-氨基-7-（2- aminomethylmorpholino）-1-环丙基-6,8-二氟-1,4-二氢氢 - 4 氧代喹啉-3-羧酸或其盐。