公开(公告)号：EP2533687A2

公开(公告)日：2012-12-19

申请号：EP12711553.3

申请日：2012-03-21

申请人： Topera, Inc. ,  The Regents Of The University Of California

发明人： BRIGGS, Carey Robert ,  NARAYAN, Sanjiv

IPC分类号： A61B5/0452

CPC分类号： A61B5/02405 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/743 ,  A61B18/02 ,  A61B18/12 ,  A61B18/18 ,  A61B2018/00577 ,  A61B2562/046

摘要： An example system and method of reconstructing cardiac activation information are disclosed. A first cardiac signal and a second cardiac signal are processed via a computing device to determine whether there is a point of change in a derivative of the first cardiac signal with respect to a derivative of the second cardiac signal above a threshold. An activation onset time is assigned in the first cardiac signal at the point of change to define cardiac activation indicating a beat in the first cardiac signal if it is determined that the point of change is above the threshold.

公开(公告)号：EP2339961B1

公开(公告)日：2018-03-07

申请号：EP09819953.2

申请日：2009-10-09

申请人： The Regents of the University of California

发明人： NARAYAN, Sanjiv ,  RAPPEL, Wouter-Jan

IPC分类号： A61B5/0464 ,  A61B5/044 ,  A61B18/12 ,  A61B5/02 ,  A61B5/0402 ,  A61B7/04 ,  A61B5/042 ,  A61B5/0452 ,  A61B18/00 ,  A61B5/00 ,  A61B5/04 ,  A61B5/046 ,  A61B5/024 ,  A61B5/0245 ,  A61B18/14 ,  A61B8/08

CPC分类号： A61B5/02405 ,  A61B5/02 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/04007 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6857 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7405 ,  A61B7/04 ,  A61B8/0883 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00839 ,  A61B2018/1435

摘要： Method, system and apparatus to detect, diagnose and treat biological rhythm disorders. In preferred particularly desirable embodiment relating to the real-time detection of heart rhythm disorders, this invention identifies localized sources for complex rhythms including atrial fibrillation to guide the localized application of energy to modify the source and treat the rhythm disorder.

公开(公告)号：EP3395243B1

公开(公告)日：2020-12-02

申请号：EP18160149.3

申请日：2009-10-09

申请人： The Regents of the University of California

发明人： NARAYAN, Sanjiv ,  RAPPEL, Wouter-Jan

IPC分类号： A61B5/04

公开(公告)号：EP2339961A1

公开(公告)日：2011-07-06

申请号：EP09819953.2

申请日：2009-10-09

申请人： The Regents of the University of California

发明人： NARAYAN, Sanjiv ,  Rappel, Wouter-Jan

IPC分类号： A61B5/04

CPC分类号： A61B5/02405 ,  A61B5/02 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/04007 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6857 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7405 ,  A61B7/04 ,  A61B8/0883 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00839 ,  A61B2018/1435

摘要： Method, system and apparatus to detect, diagnose and treat biological rhythm disorders. In preferred particularly desirable embodiment relating to the real-time detection of heart rhythm disorders, this invention identifies localized sources for complex rhythms including atrial fibrillation to guide the localized application of energy to modify the source and treat the rhythm disorder.

摘要翻译： 用于检测人心脏中复杂节律紊乱的原因的系统包括相对于心脏空间上放置的多个传感器，其中由传感器产生的信号与心脏的激活相关联。 处理器收集和分析信号以识别具有旋转或径向发射的激活轨迹的心脏区域，其中激活轨迹指示复杂节律紊乱并且基于与心脏的激活相关联的激活时间。

公开(公告)号：EP3068484A2

公开(公告)日：2016-09-21

申请号：EP14862497.6

申请日：2014-11-14

申请人： The Regents of the University of California

发明人： McCULLOCH, Andrew D. ,  KRISHNAMURTHY, Adarsh ,  VILLONGCO, Christopher ,  KRUMMEN, David ,  NARAYAN, Sanjiv ,  OMENS, Jeffrey ,  KERCKHOFFS, Roy

IPC分类号： A61N1/362

CPC分类号： A61B5/02028 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0452 ,  A61B5/4836 ,  A61B5/7275 ,  A61B6/032 ,  A61B6/503 ,  A61B6/507 ,  A61B8/0883 ,  A61B8/48 ,  A61B8/483 ,  A61B8/485 ,  A61B8/5223 ,  A61B2576/023 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/39 ,  A61N1/395 ,  G06F19/00 ,  G09B23/303 ,  G16H50/50

摘要： in alternative embodiments, provided are compositions, medical devices or products of manufacture, systems, diagnostic tools, and methods, including computer implemented methods, for predicting the response of patients with dyssynchronous heart 10 failure (DHF) to cardiac resynchronization therapy (CRT), comprising: measuring or determining the fraction of the LV/septum performing negative work (MNW); and measuring or determining the coefficient of variation of external work density (COVW), wherein the MNW fraction performing negative work and coefficient of variation COVW (sd/mean) correlated strongly with observed reduction in end-systolic volume after CRT.

公开(公告)号：EP3395243A1

公开(公告)日：2018-10-31

申请号：EP18160149.3

申请日：2009-10-09

申请人： The Regents of the University of California

发明人： NARAYAN, Sanjiv ,  RAPPEL, Wouter-Jan

IPC分类号： A61B5/04

CPC分类号： A61B5/02405 ,  A61B5/02 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/04007 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6857 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7405 ,  A61B7/04 ,  A61B8/0883 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00839 ,  A61B2018/1435

摘要： Method, system and apparatus to detect, diagnose and treat biological rhythm disorders. In preferred particularly desirable embodiment relating to the real-time detection of heart rhythm disorders, this invention identifies localized sources for complex rhythms including atrial fibrillation to guide the localized application of energy to modify the source and treat the rhythm disorder.

公开(公告)号：EP3185768A1

公开(公告)日：2017-07-05

申请号：EP15836641.9

申请日：2015-08-25

申请人： Regents of the University of California ,  Topera, Inc.

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey Robert

IPC分类号： A61B5/0408 ,  A61B5/0402 ,  A61B5/0452

CPC分类号： A61B5/7239 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7246 ,  A61B5/7264 ,  A61B2505/05 ,  A61B2562/046 ,  G06F19/00

摘要： A method of representing cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals obtained from a patient. Far-field activations are eliminated from the plurality of neighboring cardiac signals using one or more divergence criteria that define local activations in the plurality of neighboring cardiac signals, where the divergence criteria are associated with divergence among the plurality of neighboring cardiac signals. The method may also include constructing a clinical representation of local activations in the plurality of neighboring cardiac signals.

摘要翻译： 表示与心律紊乱相关的心脏信息的方法包括访问从患者获得的多个相邻心脏信号。 使用限定多个相邻心脏信号中的局部激活的一个或多个发散标准，从多个相邻心脏信号中消除远场激活，其中发散标准与多个相邻心脏信号之间的发散相关联。 该方法还可以包括构建多个相邻心脏信号中的局部激活的临床表示。