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公开(公告)号：EP1940856B1
公开(公告)日：2014-10-08
申请号：EP06806436.9
申请日：2006-10-20
发明人： AUGUSTYNS, Koen , JOOSSENS, Jurgen , VAN DER VEKEN, Pieter , LAMBEIR, Anne-Marie Virginie Renée , SCHARPÉ, Simon , HAEMERS, Achiel
IPC分类号： C07F9/40
CPC分类号： C07F9/4006 , C07F9/4084
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公开(公告)号：EP2804859A1
公开(公告)日：2014-11-26
申请号：EP13701410.6
申请日：2013-01-17
发明人： JANSEN, Koen , DE MEESTER, Ingrid , HEIRBAUT, Leen , CHENG, Jonathan D , JOOSSENS, Jurgen , AUGUSTYNS, Koen , VAN DER VEKEN, Pieter
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/401 , A61P35/00
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.
摘要翻译： 本发明涉及对FAP（成纤维细胞活化蛋白）具有高选择性和特异性的新型抑制剂。 所述抑制剂可用作人和/或兽医药物，特别是用于治疗和/或预防FAP相关疾病，例如但不限于增殖性疾病。
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公开(公告)号：EP2707034A1
公开(公告)日：2014-03-19
申请号：EP12723850.9
申请日：2012-05-09
发明人： AUGUSTYNS, Koen , VAN DER VEKEN, Pieter , MESSAGIE, Jonas , JOOSSENS, Jurgen , LAMBEIR, Anne-Marie
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C07F5/04 , C07F9/40 , C07F9/4006 , C07F9/65187 , C07F9/65522 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The present invention relates to selective trypsine-like serine protease activity-based probes, in particular urokinase plasminogen activator-activity based probes, the use thereof and methods for detecting selective urokinase activity by making use of said probes.
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