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公开(公告)号：EP0722314A1
公开(公告)日：1996-07-24
申请号：EP95924445.0
申请日：1995-07-11
IPC分类号： A61K9
CPC分类号： A61K9/0068
摘要： A bolus for delivery of pulsed doses of biologically active material to a ruminant comprises a series of distinct and separate bolus elements (1, 2, 3, 4). Each bolus element is constructed of a degradable outer sheath (b, c) and a core (a) of biologically active material. The elements are adapted to separate following administration to the ruminant, and to disperse in the rumeno-reticular sac. In due course the elements degrade or corrode to release the biologically active material. Example boli include bolus elements of different respective corrosion characteristics and, as such, are capable of releasing pulsed doses of the active material to the ruminant.
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公开(公告)号：EP0482947A1
公开(公告)日：1992-04-29
申请号：EP91309890.1
申请日：1991-10-25
CPC分类号： A61K9/0092 , A61K9/0068 , C22C23/00
摘要： The invention provides a magnesium manganese alloy suitable for use in the production of a pellet 10 for administration to a ruminant by dposition in its rumeno-reticular sac. A typical pellet 10 comprises a magnesium alloy tube 12 enclosing a degradable core formed of plurality of tablets 14, 16. The magnesium alloy used in the construction comprises at least 90% by weight of magnesium, uyp to 1% zinc and up to 2% of manganese. Preferably the alloy may further include aluminium, silicon or zirconium along with iron and beryllium. When deposited in an animal's rumen the alloy reacts with the rumen juices to form an anodic film over the exposed surface of the tube 12. This prevents corrosion or dissolution of the tube 12 except at its exposed ends where galvanic corrosion by coupling with the electrically conductive core 14, 16 is provided. The normal requirement of a non-degradable exterior coating e.g. resin for the tube exterior is obviated.
摘要翻译： 本发明提供一种镁锰合金，其适用于生产颗粒10，用于通过在其瘤胃网状囊中分层给予反刍动物。 典型的颗粒10包括包围由多个片剂14,16形成的可降解芯的镁合金管12.用于该结构的镁合金包含至少90重量％的镁，u 1至1％的锌和至多2重量％ 的锰。 优选地，合金还可以包括铝，硅或锆以及铁和铍。 当沉积在动物瘤胃中时，合金与瘤胃汁反应以在管12的暴露表面上形成阳极膜。这防止了管12的腐蚀或溶解，除了其暴露的端部，其中电偶腐蚀通过与导电 芯14,16。 不可降解的外部涂层的正常要求，例如 用于管外表面的树脂被消除。
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公开(公告)号：EP0164927B1
公开(公告)日：1988-10-26
申请号：EP85303461.9
申请日：1985-05-17
IPC分类号： A61M31/00
CPC分类号： A61K9/0068 , A61M31/002
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公开(公告)号：EP0243111A2
公开(公告)日：1987-10-28
申请号：EP87303394.8
申请日：1987-04-16
CPC分类号： A61K9/0068 , A23K40/20 , A23K40/35 , A61J3/06 , A61M31/002
摘要： A pellet for administration to ruminants to supply magnesium and other biologically active material, for example, anthelmintics or antibiotics comrpises a tube of magnesium alloy (1) enclosing a core or filling (3). The core (3) typically comprises mainly iron shot as weighting material, a biologically active material if desired and an electrically conductive material such as carbon or graphite. The graphite ensures that the core (3) as a whole is conductive and provides a cathode electrically coupled with the magnesium alloy tube (1) to form a galvanic cell. Liquor in the rumen serves as an electrolyte to cause galvanic corrosion of the magnesium tube (1) to release the active material contained in the core (3). A protective coating (5) of resin is provided on the tube's exterior surface except on at least one end (4) so that the corrosion is limited to the exposed surfaces only. An alternative embodiment (Fig. 4) comprises a control magnesium alloy rod or shaft (11) around which a cylinder (13) of the electrically conductive component is pressed. The cylinder contain iron shot and graphite in similar proportions to the core (3) in the first embodiment and is also provided with a protective resin coating (12) to restrict corrosion to one or both ends of the rod (11).
摘要翻译： 用于向反刍动物施用供应镁和其他生物活性物质的丸剂，例如驱虫剂或抗生素包含一个包围核心或填充物（3）的镁合金管（1）。 核心（3）通常主要包括作为加重材料的铁丸，如果需要的话，生物活性材料和导电材料如碳或石墨。 该石墨确保核心（3）整体上是导电的并且提供与镁合金管（1）电耦合的阴极以形成原电池。 瘤胃中的酒液作为电解液引起镁管（1）的电镀腐蚀，以释放包含在芯体（3）中的活性物质。 除了至少一端（4）之外，在管的外表面上提供树脂保护涂层（5），以使腐蚀仅限于暴露的表面。 替代实施例（图4）包括控制镁合金棒或轴（11），导电部件的气缸（13）被压在该控制镁合金杆或轴上。 圆筒包含与第一实施例中的芯（3）相似比例的铁丸和石墨，并且还设置有保护树脂涂层（12）以限制杆（11）的一端或两端的腐蚀。
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15.发明授权CONTROLLED RELEASE DEVICES AND STRUCTURAL ELEMENTS FOR USE IN THEIR MANUFACTURE 有权设备技术控制的供给和结构元素FOR USE生产
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公开(公告)号：EP0722314B1
公开(公告)日：2000-05-03
申请号：EP95924445.0
申请日：1995-07-11
IPC分类号： A61K9/00
CPC分类号： A61K9/0068
摘要： A bolus for delivery of pulsed doses of biologically active material to a ruminant comprises a series of distinct and separate bolus elements (1, 2, 3, 4). Each bolus element is constructed of a degradable outer sheath (b, c) and a core (a) of biologically active material. The elements are adapted to separate following administration to the ruminant, and to disperse in the rumeno-reticular sac. In due course the elements degrade or corrode to release the biologically active material. Example boli include bolus elements of different respective corrosion characteristics and, as such, are capable of releasing pulsed doses of the active material to the ruminant.
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公开(公告)号：EP0284258B1
公开(公告)日：1992-11-19
申请号：EP88302148.7
申请日：1988-03-11
CPC分类号： A61K9/0068 , A61D7/00 , A61M31/002
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公开(公告)号：EP0284258A1
公开(公告)日：1988-09-28
申请号：EP88302148.7
申请日：1988-03-11
CPC分类号： A61K9/0068 , A61D7/00 , A61M31/002
摘要： A bolus or pellet (10) for administration of trace elements and/or biologically active agents to ruminants is formed as compacted body (10) consisting of a particulate, non-uniform, weighting material held together by a binder, preferably wax, including a water soluble agent, such as a soap, and in which one or more biologically active agents are dispersed. Two such pellets are administered together so as to release the active agent by abrasion. A further embodiment encloses a compacted core (16) consisting of steel grit, wax, soaps and active agent in a plurality closely abutting P.V.C. rings (18) thus limiting erosion to the exposed ends only.
摘要翻译： 形成用于向反刍动物施用微量元素和/或生物活性剂的推注剂或丸剂（10），其作为压实体（10），其由通过粘合剂（优选蜡）保持在一起的颗粒状，不均匀的重量材料组成，包括 水溶性剂，例如皂，其中一种或多种生物活性剂被分散。 两个这样的丸粒一起施用以通过磨损释放活性剂。 另一实施例在多个紧密邻接的P.V.C中包括由钢砂砾，蜡，肥皂和活性剂组成的压实芯（16）。 环（18）因此仅限于暴露端的侵蚀。
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公开(公告)号：EP0164927A3
公开(公告)日：1986-10-08
申请号：EP85303461
申请日：1985-05-17
IPC分类号： A61M31/00
CPC分类号： A61K9/0068 , A61M31/002
摘要： A bolus for administering a biologically active material for example an insecticide into a liquid environment such as the water of a reservoir or lake or an anthelmintic into the rumen juices of an animal comprises a succession of liquid impermeable outer segments (153, 263) enclosing a core which in the simplest case may be a single unitary active material segment (151, Figure 14) or in a developed embodiment may comprise a succession of annular segments (269, Figure 25) contained in sealed recesses (267) in the outer segments (263) which are located on a degradable central rod (265) e.g. of magnesium alloy, which itself will be active for instance to combat magnesium deficiency. As shown in Figure 25, the device may incorporate a weight (275) which, in animal use, inhabits regurgitation. Additionally, the device may include a galvanic couple element which, with the rod (265) sets up a galvanic action which controls the speed of degradation of the rod (265) and thereby the rate of administration of the segments (26).
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公开(公告)号：EP0140632A3
公开(公告)日：1986-02-05
申请号：EP84307033
申请日：1984-10-15
CPC分类号： A61K9/0068 , A61J3/06 , A61M31/002
摘要： A pellet for administration into and reside in the rumeno-reticular sac of a ruminant and to release successive doses of an active agent, such as an anthelmentic, comprises an assembly (10) of discs (12) each having a peripheral skirt (14) on one side and an inwardly-spaced skirt (16) on the other so that such discs can interfit by said skirts (14, 16) and define therebetween cavities (18) each containing a respective active agent dose (24). A weighting slug (20) is provided at one end of the assembly (10) which is enclosed except at one end by a surrounding plastics sheath (26) so that rumen juices may attack and erode the successive discs (12) to release the successive doses (24). The discs (12) are of a magnesium-based alloy and the slug (20) is of a Zinc-based alloy.
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