公开(公告)号：EP1021726A1

公开(公告)日：2000-07-26

申请号：EP97937333.9

申请日：1997-08-19

申请人： Shaker, Ghassan I.

发明人： MEDENICA, Rajko, D. ,  POWELL, David, K.

IPC分类号： G01N33/68 ,  G01N33/574

CPC分类号： G01N33/5005 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/57488 ,  G01N33/68 ,  G01N2333/555 ,  G01N2333/565 ,  Y10S930/142

摘要： Disclosed is a method of determining the presence and activity of interferon inhibitors in a test sample, preferably human blood serum. The method includes the steps of culturing cells which express an interferon-inducible antigen in the presence of an interferon and then adding an aliquot of the cultured cells to a test sample and to a control sample. The expression of the interferon-inducible antigen is then measured in both the test sample and in the control sample and these two values compared to determine the presence and activity of interferon inhibitors in the test sample.