公开(公告)号：EP4327837A2

公开(公告)日：2024-02-28

申请号：EP23220762.1

申请日：2021-10-21

申请人： Axogen Corporation

发明人： FALERIS, Jennifer ,  TAJDARAN, Kasra

IPC分类号： A61L27/58

摘要： The present disclosure provides fasciculated nerve grafts of customizable lengths and diameters, and methods of preparing the same. The grafts are made by digesting native extracellular matrix (ECM) around the nerve fascicles of a nerve tissue, and the epineurial sheath. One or more of the individual fascicles may then be entubulated in an entubulation material, embedded in or coated with a coating material, or both, to form a fasciculated nerve graft. The fasciculated nerve grafts are customizable and designed to bridge nerve gaps; the modularity of the fasciculated nerve graft allows for restoring continuity to nerve defects of virtually any length and allows for matching the diameter of the patient's recipient nerve.

公开(公告)号：EP4326191A1

公开(公告)日：2024-02-28

申请号：EP22720878.2

申请日：2022-04-15

申请人： Tepha, Inc.

发明人： LIMEM, Skander ,  SARIIBRAHIMOGLU, Kemal ,  BUTLER, Timothy, John ,  WILLIAMS, Simon, F.

IPC分类号： A61F2/12 ,  B33Y80/00 ,  A61L27/56 ,  A61L27/58

公开(公告)号：EP4304670A1

公开(公告)日：2024-01-17

申请号：EP22719620.1

申请日：2022-03-07

申请人： Uniwersytet Medyczny w Lublinie

发明人： KLIMEK, Katarzyna ,  GINALSKA, Grazyna ,  TARCZYNSKA-OSINIAK, Marta

IPC分类号： A61L27/36 ,  A61L27/42 ,  A61L27/46 ,  A61L27/54 ,  A61L27/58

公开(公告)号：EP3727198B1

公开(公告)日：2024-01-17

申请号：EP18890448.6

申请日：2018-12-21

发明人： BRENNAN, Paul ,  MOORE, Timothy Graeme

IPC分类号： A61F2/12 ,  A61L27/56 ,  A61L27/34 ,  C08G18/06 ,  C08J9/08 ,  B32B27/40 ,  A61F2/00 ,  A61L27/18 ,  A61L27/58 ,  B32B1/02 ,  B32B5/02 ,  C08G101/00 ,  C08G18/73 ,  C08G18/42 ,  C08G18/10 ,  B32B7/12 ,  B32B5/32 ,  B32B27/34 ,  B32B5/24 ,  B32B27/08

公开(公告)号：EP3662939B1

公开(公告)日：2024-01-03

申请号：EP19198978.9

申请日：2016-08-30

发明人： SHELTON, IV Frederick E. ,  HARRIS, Jason L. ,  WIDENHOUSE, Tamara S.

IPC分类号： A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61B17/072 ,  A61B17/115 ,  A61B17/00 ,  A61P43/00 ,  A61B17/064 ,  A61B17/29

公开(公告)号：EP4257202A3

公开(公告)日：2023-12-20

申请号：EP23168344.2

申请日：2012-11-09

申请人： Trustees of Tufts College ,  University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Wake Forest University Health Services

发明人： BELLAS, Evangelia ,  MARRA, Kacey ,  RUBIN, Peter J. ,  KAPLAN, David L. ,  YOO, James J.

IPC分类号： A61L27/22 ,  A61L27/54 ,  A61L27/14 ,  A61M25/00 ,  A61M5/178 ,  A61L27/36 ,  A61L27/38 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61P15/08 ,  A61P17/00 ,  A61P19/04 ,  A61P21/00 ,  A61P43/00

摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.

公开(公告)号：EP3852824B1

公开(公告)日：2023-12-13

申请号：EP20767872.3

申请日：2020-08-05

发明人： FATTORI, Paolo

IPC分类号： A61L27/36 ,  A61L27/56 ,  A61L27/58 ,  A61L31/00 ,  A61L31/08 ,  A61L31/14 ,  A61L27/06 ,  A61L31/02

公开(公告)号：EP3381482B1

公开(公告)日：2023-11-22

申请号：EP17789716.2

申请日：2017-04-28

发明人： KASUGA, Toshihiro ,  NISHIKAWA, Yasutoshi

IPC分类号： A61L27/18 ,  A61L27/12 ,  A61L27/46 ,  A61L27/58 ,  D01D5/08 ,  D01F1/02 ,  D01F6/62 ,  A61L27/56

公开(公告)号：EP4255517A1

公开(公告)日：2023-10-11

申请号：EP21827197.1

申请日：2021-11-30

申请人： Anika Therapeutics, Inc.

发明人： AGNELLO, Stefano ,  AHN, Edward ,  CENTOLA, Matteo ,  EK, Steven W. ,  KENNEDY, Stephen J. ,  MANNARINO, Matthew M. ,  MARCHETTO, Elvira ,  PURI, Sonali ,  RICHARD, Robert ,  SIMONCIONI, Sara

IPC分类号： A61L27/38 ,  A61L27/44 ,  A61L27/46 ,  A61L27/58 ,  A61L27/56 ,  A61L27/20 ,  B32B5/00 ,  B32B27/00

公开(公告)号：EP4236965A1

公开(公告)日：2023-09-06

申请号：EP21887401.4

申请日：2021-10-27

申请人： New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery

发明人： CONG, Guang-Ting ,  CUNNINGHAM, Matthew

IPC分类号： A61K31/713 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/675 ,  A61K35/33 ,  A61L27/58 ,  A61K35/32