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公开(公告)号：EP3710428A1
公开(公告)日：2020-09-23
申请号：EP18811984.6
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , PLIUSHCHEV, Marina, A. , TONG, Yunsong , BLACK, Lawrence, A. , XU, Xiangdong , SHI, Lei , ZHANG, Qingwei, I. , CHUNG, Seungwon , SWEIS, Ramzi, Farah , DART, Michael, J. , RANDOLPH, John, T. , MURAUSKI, Kathleen
IPC分类号： C07D213/74 , C07C255/57 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07D235/14 , C07D307/56 , C07D307/82 , C07D317/62 , C07D401/04 , C07D413/04 , C07D487/04 , C07D275/03 , C07D495/04 , C07D513/04 , C07D213/54 , A61P35/00 , A61K31/165
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公开(公告)号：EP3680253A2
公开(公告)日：2020-07-15
申请号：EP20150745.6
申请日：2011-02-28
申请人： AbbVie Inc.
IPC分类号： C07K16/18
摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
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公开(公告)号：EP3675908A1
公开(公告)日：2020-07-08
申请号：EP18852351.8
申请日：2018-09-04
申请人： AbbVie Inc.
发明人： REILLY, Edward , ANDERSON, Mark
IPC分类号： A61K39/395 , A61K45/06 , C07K16/40
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24.发明授权
公开(公告)号：EP3191471B1
公开(公告)日：2020-03-11
申请号：EP15762980.9
申请日：2015-09-10
发明人： AMBERG, Wilhelm , BREWER, Jason T. , HUTCHINS, Charles , LANGE, Udo , LAO, Yanbin , LI, Huan-Qiu , POHLKI, Frauke , VASUDEVAN, Anil , WANG, Ying , ZHAO, Hongyu
IPC分类号： C07D403/12
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公开(公告)号：EP3612461A1
公开(公告)日：2020-02-26
申请号：EP18722827.5
申请日：2018-04-16
申请人： AbbVie Inc.
发明人： BORGARDT, Joy Elizabeth , HUGHES, James J. , KLIKUSZOWIAN, Ted , MARSHALL, Todd , PLEW, Marc , COFFEY, Kelsey M. , FISHER, Scott L. , ROWE, Jason A.
IPC分类号： B65D51/22
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26.发明公开
公开(公告)号：EP3601255A1
公开(公告)日：2020-02-05
申请号：EP18716451.2
申请日：2018-03-20
发明人： BACKFISCH, Gisela , BAKKER, Margaretha , BLACK, Lawrence , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , KLING, Andreas , LAKICS, Viktor , MACK, Helmut , RELO, Ana Lucia , OELLIEN, Frank
IPC分类号： C07D401/12 , C07D405/12 , C07D207/16 , A61P25/24 , A61P25/14 , A61P9/00 , A61P25/22 , A61P25/28 , A61P25/18 , A61P25/30 , A61P3/10 , A61K31/40
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公开(公告)号：EP3592353A1
公开(公告)日：2020-01-15
申请号：EP18712786.5
申请日：2018-03-09
申请人： AbbVie Inc.
发明人： THAKKAR, Roopal B. , JUNGERWIRTH, Steven , MACHADO DE LACERDA, Ana Paula , ROBINSON, Anne M. , ENEJOSA, Jose Jeffrey V. , PANGAN, Aileen L. , MOHAMED, Mohamed-Eslam , OTHMAN, Ahmed , KLUNDER, Ben , ALLIAN, Ayman, D. , BORCHARDT, Thomas, B. , NORDSTROM, Fredrik Lars. , SHEIKH, Ahmad, Y. , MULHERN, Mathew,M. , JAYANTH, Jayanthy. , MARROUM, Patrick, J. , MAYER, Peter, T.
IPC分类号： A61K31/495 , A61P1/00
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公开(公告)号：EP3303395B1
公开(公告)日：2019-12-11
申请号：EP16728520.4
申请日：2016-05-27
申请人： AbbVie Inc.
发明人： BENATUIL, Lorenzo , ARGIRIADI, Maria, A. , MCRAE, Bradford, L. , HSIEH, Chung-Ming , EGAN, David A. , HARLAN, John E. , JUDGE, Russell A. , WANG, Rui , KINGSBURY, Gillian A.
IPC分类号： C07K16/28 , A61K39/395 , C12N15/13 , A61K39/00
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30.发明公开
公开(公告)号：EP3569588A1
公开(公告)日：2019-11-20
申请号：EP19183264.1
申请日：2014-03-12
申请人： AbbVie Inc.
发明人： BARKALOW, Jufang , CALIFANO, Jean-christophe , CHAN, Vincent S. , CHRISTENSEN, Alan C. , GRIEME, Timothy A. , KU, Yi-Yin , MULHERN, Mathew M. , PU, Yu-ming M.
IPC分类号： C07C67/343
摘要： Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.
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