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    PROGNOSTIC TESTS FOR HEPATIC DISORDERS
    22.
    发明公开
    PROGNOSTIC TESTS FOR HEPATIC DISORDERS 审中-公开
    PROGNOSTISCHE测试FÜRLEBERSTÖRUNGEN

    公开(公告)号：EP3129787A1

    公开(公告)日：2017-02-15

    申请号：EP15713925.4

    申请日：2015-04-08

    申请人： Centre Hospitalier Universitaire D'angers ,  Université d'Angers

    发明人： CALÈS, Paul ,  BOURSIER, Jérôme ,  BERTRAIS, Sandrine

    IPC分类号： G01N33/576 ,  G01N33/68

    CPC分类号： G06F19/3437 ,  G01N33/576 ,  G01N33/6893 ,  G01N2800/08 ,  G06F17/18 ,  G06F19/00 ,  G06F19/3431 ,  G16H50/30 ,  G16H50/50

    摘要： The present invention relates to in vitro prognostic method for assessing the risk of death or of liver-related event in a subject, comprising: a. obtaining at least one, preferably at least 2, of the following variables from the subject: i. biomarkers measured in a sample from the subject; ii. clinical data; iii. binary markers; iv. blood test results; b. optionally obtaining at least one blood test result by univariate combination, preferably with a binary logistic regression, of the at least one variable obtained in step (a), said blood test not being a Fibrotest, c. obtaining at least one physical data from medical imaging or clinical measurement, preferably from elastometry, more preferably from Vibration Controlled Transient Elastography (VCTE), and d. mathematically combining in a multivariate time-dependent model - said at least one variable obtained in step (a) and/or said at least one blood test result obtained in step b); and - said at least one physical data, obtained in step (c) thereby obtaining a prognostic score.

    摘要翻译： 本发明涉及用于评估受试者的死亡风险或肝脏相关事件的体外预后方法，包括：a。 从主题中获得至少一个，优选至少2个以下变量：i。 在受试者样本中测量的生物标志物; II。 临床资料; III。 二进制标记 IV。 血液检查结果; 湾 任选地通过单因素组合（优选用二元逻辑回归）获得至少一个在步骤（a）中获得的至少一个变量的血液测试结果，所述血液测试不是Fibrotest，c。 从医学成像或临床测量获得至少一个物理数据，优选地来自弹性测量，更优选地来自振动控制瞬态弹性成像（VCTE），以及d。 在多变量时间依赖模型中数学组合 - 所述步骤（a）中获得的至少一个变量和/或步骤b）中获得的所述至少一个血液测试结果; 和 - 在步骤（c）中获得的至少一个物理数据，由此获得预后评分。

    Prognostic tests for hepatic disorders
    23.
    发明公开
    Prognostic tests for hepatic disorders 审中-公开
    预测测试费尔伯斯特伦根

    公开(公告)号：EP2930515A1

    公开(公告)日：2015-10-14

    申请号：EP14163948.4

    申请日：2014-04-08

    申请人： UNIVERSITE D'ANGERS ,  Centre Hospitalier Universitaire d'Angers

    发明人： Calès, Paul ,  Boursier, Jérôme ,  Bertrais, Sandrine

    IPC分类号： G01N33/576 ,  G01N33/68

    CPC分类号： G06F19/3437 ,  G01N33/576 ,  G01N33/6893 ,  G01N2800/08 ,  G06F17/18 ,  G06F19/00 ,  G06F19/3431 ,  G16H50/30 ,  G16H50/50

    摘要： The present invention relates to in vitro prognostic method for assessing the risk of death or of liver-related event in a subject, comprising:
    a. obtaining at least one, preferably at least 2, of the following variables from the subject:
    i. biomarkers measured in a sample from the subject;
    ii. clinical data;
    iii. binary markers;
    iv. blood test results;

    b. optionally obtaining at least one blood test result by univariate combination, preferably with a binary logistic regression, of the at least one variable obtained in step (a), said blood test not being a Fibrotest,
    c. obtaining at least one physical data from medical imaging or clinical measurement, preferably from elastometry, more preferably from Vibration Controlled Transient Elastography (VCTE), and
    d. mathematically combining in a multivariate time-dependent model
    - said at least one variable obtained in step (a) and/or said at least one blood test result obtained in step b); and
    - said at least one physical data, obtained in step (c)

    thereby obtaining a prognostic score.

    摘要翻译： 本发明涉及用于评估受试者的死亡风险或肝脏相关事件的体外预后方法，包括：a。 从主题中获得至少一个，优选至少2个以下变量：i。 在受试者样本中测量的生物标志物; II。 临床资料; III。 二进制标记 IV。 血液检查结果; 湾 任选地通过单因素组合（优选用二元逻辑回归）获得至少一个在步骤（a）中获得的至少一个变量的血液测试结果，所述血液测试不是Fibrotest，c。 从医学成像或临床测量获得至少一个物理数据，优选地来自弹性测量，更优选地来自振动控制瞬态弹性成像（VCTE），以及d。 在多变量时间依赖模型中数学组合 - 所述步骤（a）中获得的至少一个变量和/或步骤b）中获得的所述至少一个血液测试结果; 和 - 在步骤（c）中获得的至少一个物理数据，由此获得预后评分。