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    CROSS-SPECIES-SPECIFIC SINGLE DOMAIN BISPECIFIC SINGLE CHAIN ANTIBODY
    22.
    发明公开
    CROSS-SPECIES-SPECIFIC SINGLE DOMAIN BISPECIFIC SINGLE CHAIN ANTIBODY 审中-公开

    公开(公告)号：EP3375790A1

    公开(公告)日：2018-09-19

    申请号：EP18150003.4

    申请日：2009-10-01

    申请人： Amgen Research (Munich) GmbH

    发明人： KUFER, Peter ,  RAUM, Tobias

    IPC分类号： C07K16/28 ,  C07K16/22 ,  C07K16/30 ,  C07K16/40

    CPC分类号： C07K16/2863 ,  C07K16/2803 ,  C07K16/2878 ,  C07K16/2884 ,  C07K2317/31 ,  C07K2317/34

    摘要： The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain consisting of one antibody variable domain capable of binding to an epitope of the human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an epitope of a human and a non-chimpanzee primate tumor target antigen. The invention further relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non- chimpanzee primate CD3ε (epsilon) chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain consisting of one antibody variable domain capable of binding to an epitope of a human and a non-chimpanzee primate tumor target antigen. The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.

    LONG LIFE POLYPEPTIDE BINDING MOLECULES
    26.
    发明公开
    LONG LIFE POLYPEPTIDE BINDING MOLECULES 有权
    长寿多肽结合分子

    公开(公告)号：EP2820047A1

    公开(公告)日：2015-01-07

    申请号：EP13716734.2

    申请日：2013-03-01

    申请人： Amgen Research (Munich) GmbH

    发明人： KUFER, Peter ,  RAUM, Tobias ,  LUTTERBUESE, Ralf ,  HOFFMANN, Patrick ,  MUENZ, Markus ,  BROZY, Johannes ,  KVESIC, Majk

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2809 ,  C07K16/26 ,  C07K16/30 ,  C07K16/3069 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/32

    摘要： The present invention relates to a binding molecule comprising at least three domains comprised in at least one polypeptide chain, wherein the first binding domain is a binding domain which is capable of binding to a cell surface molecule on a target cell, the second binding domain is a binding domain which is capable of binding to the T cell CD3 receptor complex, and the third domain is a binding domain which is capable of binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

    摘要翻译： 本发明涉及包含至少一个多肽链中包含的至少三个结构域的结合分子，其中第一个结合结构域是能够结合靶细胞上的细胞表面分子的结合结构域，第二个结合结构域是 能够结合T细胞CD3受体复合物的结合结构域，并且第三结构域是能够结合血清白蛋白的结合结构域，其中所述第三结构域位于所述第二结构域的C端。 此外，本发明提供了编码结合分子的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明提供了生产本发明结合分子的方法，所述结合分子的医学用途以及包含所述结合分子的试剂盒。