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    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    23.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2962109A1

    公开(公告)日：2016-01-06

    申请号：EP14756519.6

    申请日：2014-02-26

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/566

    CPC分类号： G01N33/6893 ,  G01N2333/4724 ,  G01N2333/565 ,  G01N2333/71 ,  G01N2333/90203 ,  G01N2800/347 ,  G01N2800/60

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Coagulation factor X, Coagulation factor V, soluble Receptor tyrosine- protein kinase erbB-2, Interferon beta, C-type lectin domain family 11 member A, Glyceraldehyde- 3 -phosphate dehydrogenase, Interferon omega- 1, Coagulation factor VIII, Thrombin- Antithrombin- III complex, and soluble Tumor necrosis factor ligand superfamily member 13B as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用一种或多种配置为检测选自由凝血因子X，凝血因子V，可溶性受体酪氨酸 - 蛋白激酶erbB-2，干扰素β，C型组成的组的肾损伤标志物的测定 凝集素结构域家族11成员A，甘油醛-3-磷酸脱氢酶，干扰素ω-1，凝血因子VIII，凝血酶 - 抗凝血酶-III复合物和可溶性肿瘤坏死因子配体超家族成员13B作为肾损伤中的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    25.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2513649A1

    公开(公告)日：2012-10-24

    申请号：EP10838357.1

    申请日：2010-12-20

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/52

    摘要： The invention refers to a method for evaluating renal status in a subject, comprising: performing a plurality of assays configured to detect a plurality of kidney injury markers selected from the group consisting of Hyaluronic acid, Immunoglobulin A, Immunoglobulin G1, Immunoglobulin G2, Insulin-like growth factor-binding protein 7, Alpha-1 antitrypsin, Serum amyloid P component, Metalloproteinase inhibitor 2, Hepatocyte growth factor, Intercellular adhesion molecule 1, Beta-2-glycoprotein 1, Interleukin-1 beta, Neutrophil Elastase, Tumor necrosis factor receptor superfamily member 11B, Interleukin-11, Cathepsin D, C-C motif chemokine 24, C-X-C motif chemokine 6, C-C motif chemokine 13, C-X-C motif chemokines -1, -2, and -3, Matrilysin, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, and Macrophage colony-stimulating factor 1 on a body fluid sample obtained from the subject to provide one or more assay results; and correlating the assay results to the renal status of the subject.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用多种测定法，其中一种或多种测定法被配置为检测选自透明质酸，免疫球蛋白A，免疫球蛋白G1，免疫球蛋白G2，胰岛素样生长因子-α， 结合蛋白7，α-1抗胰蛋白酶，血清淀粉样蛋白P成分，金属蛋白酶抑制剂2，肝细胞生长因子，细胞间粘附分子1，β-2-糖蛋白1，白细胞介素-1β，嗜中性粒细胞弹性蛋白酶，肿瘤坏死因子受体超家族成员11B， 白细胞介素-11，组织蛋白酶D，C-C基序趋化因子24，C-X基元趋化因子6，C-C基序趋化因子13，C- X-C基序趋化因子-1，-2和-3，基质溶素，白细胞介素 -2受体α链，胰岛素样生长因子结合蛋白3和巨噬细胞集落刺激因子1作为肾损伤诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    26.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    VERFAHREN ZUR DIAGNOSE UND PROGNOSE VON NIERENVERLETZUNGEN UND NIERENINSUFFIZIENZ

    公开(公告)号：EP2496258A1

    公开(公告)日：2012-09-12

    申请号：EP10829191.5

    申请日：2010-11-05

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： A61K39/395

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of C-C motif chemokine 23, Transmembrane glycoprotein NMB, Brain- derived neurotrophic factor, Cathepsin S, Transforming growth factor beta-2, Urokinase- type plasminogen activator, Angiopoietin-2, Matrilysin, Carcinoembryonic antigen- related cell adhesion molecule 1, Creatine kinase MB, Insulin, Immunoglobulin M, Immunoglobulin E, Macrophage migration inhibitory factor, Galectin-3, Transforming growth factor beta-3, Heparan sulfate, soluble Cadherin-3, Complement C5, Platelet factor 4, Platelet basic protein, and Stromelysin-2 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于在患有或怀疑患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自CC基序趋化因子23，跨膜糖蛋白NMB，脑衍生的神经营养因子，组织蛋白酶S，转化生长因子β-2 ，尿激酶型纤溶酶原激活物，促血管生成素-2，Matrilysin，癌胚抗原相关细胞粘附分子1，肌酸激酶MB，胰岛素，免疫球蛋白M，免疫球蛋白E，巨噬细胞迁移抑制因子，半乳凝素-3，转化生长因子β-3， 硫酸肝素，可溶性钙粘蛋白-3，补体C5，血小板因子4，血小板碱性蛋白和基质溶蛋白-2作为肾损伤的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    28.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2324355A1

    公开(公告)日：2011-05-25

    申请号：EP09810695.8

    申请日：2009-08-28

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2800/347

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble p-selectin, protein NOV homolog, soluble epidermal growth factor receptor, netrin-4, haptoglobin, heat shock protein beta-1, alpha- 1 -antitrypsin, leukocyte elastase, soluble tumor necrosis factor receptor superfamily member 6, soluble tumor necrosis factor ligand superfamily member 6, soluble intercellular adhesion molecule 2, active caspase-3, and soluble platelet endothelial cell adhesion molecule as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 特别地，本发明涉及使用检测选自以下的一种或多种标记物的测定法：可溶性p-选择素，蛋白质NOV同系物，可溶性表皮生长因子受体，netrin-4，触珠蛋白，热休克蛋白β-1， - 1-抗胰蛋白酶，白细胞弹性蛋白酶，可溶性肿瘤坏死因子受体超家族成员6，可溶性肿瘤坏死因子配体超家族成员6，可溶性细胞间粘附分子2，活性半胱天冬酶-3和可溶性血小板内皮细胞粘附分子作为诊断和预后生物标志物 肾脏损伤。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    29.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开

    公开(公告)号：EP3828544A1

    公开(公告)日：2021-06-02

    申请号：EP20201404.9

    申请日：2012-01-08

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James Patrick

    IPC分类号： G01N33/53 ,  G01N33/68 ,  C12Q1/6883

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Proheparin-binding EGF-like growth factor, Tenascin C, Angiopoietin-related protein 4, Fibroblast growth factor 19, Fibroblast growth factor 21, Heparin-binding growth factor 1, Angiopoietin-related protein 6, Proepiregulin, Probetacellulin, Amphiregulin, Angiogenin, Thrombospondin-2, and Collagen alpha-1(XVIII) chain as diagnostic and prognostic biomarkers in renal injuries.