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21.发明公开PHARMACEUTICAL COMBINATIONS COMPRISING DUAL ANGIOPOIETIN-2 / DLL4 BINDERS AND ANTI-VEGF AGENTS 审中-公开药物化合物血管生成素-2 / DLL4双粘合剂和抗VEGF剂
公开(公告)号：EP2900260A1
公开(公告)日：2015-08-05
申请号：EP13766386.0
申请日：2013-09-26
发明人： GSCHWIND, Andreas , BAUM, Anke
IPC分类号： A61K39/395 , C07K16/22 , A61P35/00
CPC分类号： A61K39/3955 , A61K31/496 , A61K38/1761 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/22 , C07K2317/31 , A61K2300/00
摘要： The present invention relates to pharmaceutical combinations comprising dual Angiopoietin-2 / Dll4 binders and anti-VEGF agents for use in treating diseases like cancer and ocular diseases.
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22.发明公开2, 4-DIAMINOPYRIMIDINDERIVATE ZUR BEHANDLUNG UND/ODER PRÄVENTION VON KREBS, INFEKTIONEN, ENTZÜNDUNGS- UND AUTOIMMUNERKRANKUNGEN 有权2，用于治疗和/或预防癌症，感染，炎症和自身免疫性疾病的4-氨基嘧啶衍生物
公开(公告)号：EP1989198A1
公开(公告)日：2008-11-12
申请号：EP07704662.1
申请日：2007-02-20
发明人： STADTMUELLER, Heinz , BAUM, Anke , BOEHMELT, Guido , ENGELHARDT, Harald , QUANT, Jens , SOLCA, Flavio , STEEGMAIER, Martin , ZAHN, Stephan Karl
IPC分类号： C07D403/12 , C07D413/12 , C07D498/04 , A61K31/551 , A61K31/553 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D498/04 , C07D403/12 , C07D413/12 , C07D487/04
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R6, X and Y are each as defined in claim 1, which are suitable for treating disorders which are characterized by excessive or abnormal cell proliferation, and to their use for producing a medicament with the aforementioned properties.
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