-
公开(公告)号：EP1809670A2
公开(公告)日：2007-07-25
申请号：EP05798323.1
申请日：2005-09-19
申请人： MEDAREX, INC.
IPC分类号： C07K16/00 , A61K39/395 , C07H21/04 , C12N5/06 , C12N15/00 , C12Q1/68 , C12P21/06 , A01K67/027
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/2803 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-4 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-4, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
-
公开(公告)号：EP1711207A2
公开(公告)日：2006-10-18
申请号：EP04814015.6
申请日：2004-12-10
申请人： MEDAREX, INC.
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
-
搜索结果
22 条记录 (耗时 0.011 秒)
