公开(公告)号：EP1809670A2

公开(公告)日：2007-07-25

申请号：EP05798323.1

申请日：2005-09-19

申请人： MEDAREX, INC.

发明人： SRINIVASAN, Mohan ,  CARDARELLI, Josephine, M. ,  HUANG, Haichun

IPC分类号： C07K16/00 ,  A61K39/395 ,  C07H21/04 ,  C12N5/06 ,  C12N15/00 ,  C12Q1/68 ,  C12P21/06 ,  A01K67/027

CPC分类号： C07K16/283 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-4 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-4, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.