TRAINING A MACHINE LEARNING ALGORITHM USING DIGITALLY RECONSTRUCTED RADIOGRAPHS

    公开(公告)号:EP4390766A3

    公开(公告)日:2024-09-11

    申请号:EP24167514.9

    申请日:2019-09-20

    申请人: Brainlab AG

    摘要: Disclosed is a computer-implemented method of training a likelihood-based computational model for determining the position of an image representation of an annotated anatomical structure in a two-dimensional x-ray image, wherein the method encompasses inputting medical DRRs together with annotation to a machine learning algorithm to train the algorithm, i.e. to generate adapted learnable parameters of the machine learning model. The annotations may be derived from metadata associated with the DRRs or may be included in atlas data which is matched with the DRRs to establish a relation between the annotations included in the atlas data and the DRRs. The thus generated machine learning algorithm may then be used to analyse clinical or synthesized DRRs so as to appropriately add annotations to those DRRs and/or identify the position of an anatomical structure in those DRRs.

    GENERATING IMAGE-BASED BIOMARKERS FOR ALZHEIMER'S DISEASE AND RELATED DEMENTIAS

    公开(公告)号:EP4414998A1

    公开(公告)日:2024-08-14

    申请号:EP23156236.4

    申请日:2023-02-13

    发明人: XIE, Long GIBSON, Eli

    IPC分类号: G16H50/70 G16H30/40 G16H50/20

    CPC分类号: G16H50/70 G16H50/20 G16H30/40

    摘要: The present invention relates to methods and apparatuses and a system as well as to computer program for providing image-based biomarkers for active disease progression of Alzheimer's disease and related dementias (ADRD) by training and using artificial neural networks (ANNs) on the basis of subject's images. The method or system comprises a cross-sectional sub-pipeline and a longitudinal sub-pipeline for processing different images parts, namely cross-sectional imaging data and longitudinal imaging data. A patch-based multiple instance learning (MIL) scheme is applied.