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公开(公告)号：EP2691017A2
公开(公告)日：2014-02-05
申请号：EP12764542.2
申请日：2012-03-29
Applicant: Howard University
Inventor： ANDERSON, John M. M.
IPC: A61B5/026
CPC classification number: A61B6/5217 , A61B5/02755 , A61B6/037 , A61B6/481 , A61B6/503 , A61B6/507 , G06F19/00 , G06T7/0016 , G06T2207/10104 , G06T2207/30104 , G16H50/50
Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.
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32.发明公开METHOD FOR IDENTIFYING COMPOUNDS TO INCREASE THE EXPRESSION OR ACTIVITY OF ASPARTYL AMINOPEPTIDASE 有权方法鉴定化合物用于增加表达或活性天冬氨肽酶
公开(公告)号：EP2619330A1
公开(公告)日：2013-07-31
申请号：EP11827554.4
申请日：2011-09-22
Applicant: Howard University
Inventor： CHEN, Yuanxiu
CPC classification number: A61K31/7088 , G01N33/507 , G01N33/573 , G01N2333/948 , G01N2410/02
Abstract: The methods provided herein are based on the discovery, as described in more detail herein, that aspartyl aminopeptidase (DAP) is expressed in mammalian pancreatic islet cells and that increased DAP expression results in decreased angiotensin II (Ang II) levels in the islet cells. Methods are provided for identifying compounds effective to increase the expression and/or activity of DAP in mammalian pancreatic islet cells and thereby are effective to decrease Ang II levels in the islet cells. Methods are also provided for decreasing Ang II levels in a subject having Ang II induced pancreas islet cell dysfunction and/or suffering or susceptible to type 1 diabetes, as well as for the treatment or prevention of type 1 diabetes comprising administering to the subject a therapeutically effective amount of the compound identified according to the methods herein.
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33.发明公开METHOD AND APPARATUS FOR REDUCING WEAR OF SURFACES IN CONTACT WITH ONE ANOTHER 审中-公开方法和装置以降低对方的磨损接触相关曲面
公开(公告)号：EP2417232A1
公开(公告)日：2012-02-15
申请号：EP10723440.3
申请日：2010-04-05
Applicant: The Boeing Company , Howard University
Inventor： MOSLEH, Mohsen , BELK, John, H.
IPC: C10M103/00 , C10M103/06 , C10M125/20 , C10M125/22 , C10N10/12 , C10N20/06 , C10N40/22 , C10N50/08 , C10N70/00
Abstract: A method for reducing wear between two surfaces in sliding contact with one another includes introducing nanoparticles between the two surfaces in an amount and having a composition that results in shear lines being generated within at least one agglomerated wear particle that is generated between the two surfaces as a result of the sliding contact, and subjecting the agglomerated wear particles to at least one load, using at least one of the two surfaces, such that the agglomerated wear particles disassemble along the shear lines into multiple smaller wear particles.
Abstract translation: 并导致剪切线被至少一个凝聚的磨损颗粒内产生一种用于降低两个表面之间的磨损在滑动接触彼此包括将所述两个表面之间的纳米粒子在数量和具有组合物的方法也被两个表面作为之间产生 的至少一个负载，使用两个表面中的至少一个，检测滑动接触，以及使附聚的磨损颗粒的结果做了附聚的磨粒沿剪切线成多个较小的磨损颗粒拆卸。
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34.发明公开3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES 有权3-烷氧羰基-2,3-二氢-1H-吩噻嗪-4（10H） - 酮衍生物
公开(公告)号：EP1027055A1
公开(公告)日：2000-08-16
申请号：EP98955131.2
申请日：1998-10-27
Applicant: HOWARD UNIVERSITY
Inventor： SCOTT, Kenneth, R. , LAWS, Mia, L. , ROBERTS, Ralph, R. , NICHOLSON, Jesse, M.
IPC: A61K31/54 , C07D279/20
CPC classification number: C07D279/20
Abstract: Phenothiazines of formula (I) where R1 is H or -COOR, where R is selected from the group consisting of branched or unbranched alkyl groups containing from 1 to 4 carbon atoms, and where X is selected from H, branched or unbranched alkyl groups containing from 1 to 4 carbons, and halogen, and pharmaceutically acceptable salts thereof. Particularly preferred phenothiazines are those wherein X is hydrogen, chloro, bromo or methyl, R1 is COOR, and R is methyl, ethyl or t-butyl.
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公开(公告)号：EP0834197A2
公开(公告)日：1998-04-08
申请号：EP96919320.0
申请日：1996-06-06
Applicant: PURDUE RESEARCH FOUNDATION , HOWARD UNIVERSITY
IPC: H01K1
CPC classification number: H01K1/10
Abstract: Energy conversion among heat or electricity and incandescent light is achieved, in the case of incandescent light emission, with the emission having reduced IR content, using a high bandgap semiconductor element (1) that is tailored in structure and in energy conversion physics to suppress free carrier absorption so as to be transparent or reflecting of photon energy that is below the bandgap of the semiconductor and to only emit photon energy above the bandgap of the semiconductor. A filament of lightly 'N' doped 3C-Sic (2), at about 900 degrees C, will incandesce and radiate in the visible range for energies greater than about 2 eV and will exhibit inefficient emission of photons for energies less than about 2 eV.
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Patent Agency Ranking36.发明公开
公开(公告)号：EP4164746A1
公开(公告)日：2023-04-19
申请号：EP21823014.2
申请日：2021-06-10
Applicant: Howard University
Inventor： TIZABI, Yousef , COPELAND, Robert L.
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公开(公告)号：EP3939560A1
公开(公告)日：2022-01-19
申请号：EP21188686.6
申请日：2014-06-06
Applicant: Howard University
Abstract: Described herein are compositions and methods which produce hydrolytically stable resin monomers, bioactive fillers, phosphorus coupling agent and surface coating method, which can be combined to produce new generation dental composites; compositions comprising the same, as well as methods of making and using the same are also described.
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公开(公告)号：EP3913836A1
公开(公告)日：2021-11-24
申请号：EP21178980.5
申请日：2012-04-13
Applicant: Howard University
Inventor： KIM, Charles J.
Abstract: Data associated with at least one building condition or status is sensed by one or more sensors. The data from these sensors may be sent over a data bus and received by the central computer. In addition, a modulated signal may be transmitted by one or both of the transmitters across the data bus. The modulated signal is received at the receiver, which analyzes the received modulated signal, and determines whether an intermittent fault has occurred on the data bus based upon the analyzing. For example, the receiver may compare the received signal to an expected pattern and when a discrepancy exists, an intermittent fault is determined to exist. The receiver may also determine the location of the fault based upon the analysis.
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公开(公告)号：EP3270933B1
公开(公告)日：2020-08-19
申请号：EP16769440.5
申请日：2016-03-18
Applicant: Howard University
Inventor： MITCHELL, James W. , YANG, Dazhi
IPC: A61K31/715 , A61K31/717 , A61K31/738 , A61K31/785 , A61P7/08 , B01J20/24 , B01J20/26 , B01J20/28 , B01J20/30
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公开(公告)号：EP2417232B1
公开(公告)日：2020-07-22
申请号：EP10723440.3
申请日：2010-04-05
Applicant: The Boeing Company , Howard University
Inventor： MOSLEH, Mohsen , BELK, John, H.
IPC: C10M103/00 , C10M103/06 , C10M125/20 , C10M125/22 , C10N10/12 , C10N20/06 , C10N40/22 , C10N50/08 , C10N70/00
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