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31.
公开(公告)号:EP3927763A1
公开(公告)日:2021-12-29
申请号:EP20706211.8
申请日:2020-02-18
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公开(公告)号:EP3856716A1
公开(公告)日:2021-08-04
申请号:EP19783459.1
申请日:2019-09-27
申请人: Université de Caen Normandie , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre national de la recherche scientifique , Université de Montpellier
IPC分类号: C07D211/32 , A61K31/445 , A61P25/28
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公开(公告)号:EP3856163A1
公开(公告)日:2021-08-04
申请号:EP19783239.7
申请日:2019-09-27
申请人: Université de Caen Normandie , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Centre national de la recherche scientifique , Université de Montpellier
IPC分类号: A61K31/166 , A61K31/27 , A61K31/404 , A61K31/439 , A61K31/445 , A61K31/4468 , A61K31/4525 , A61K31/473 , A61K31/5375 , A61K31/55 , A61P25/28
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公开(公告)号:EP3364930B1
公开(公告)日:2020-09-23
申请号:EP16809459.7
申请日:2016-10-19
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公开(公告)号:EP3649120A1
公开(公告)日:2020-05-13
申请号:EP18734836.2
申请日:2018-07-05
IPC分类号: C07D403/06 , A61K51/04 , C07D327/04 , C07D327/06 , C07D411/14
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公开(公告)号:EP3102610B1
公开(公告)日:2020-01-22
申请号:EP15706386.8
申请日:2015-02-09
申请人: Katholieke Universiteit Leuven , INSERM - Institut National de la Santé et de la Recherche Médicale , Université de Caen Basse Normandie , Centre Hospitalier Universitaire de Caen
发明人: DECLERCK, Paul , DE MEYER, Simon , GEUKENS, Nick , GILS, Ann , RUBIO, Marina , VIVIEN, Denis , WYSEURE, Tine
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公开(公告)号:EP3441138A1
公开(公告)日:2019-02-13
申请号:EP17306054.2
申请日:2017-08-08
发明人: VALABLE, Samuel , MINTOVA LAZAROVA, Svetlana , ANFRAY, Clément , VALTCHEV, Valentin , TOUZANI, Omar , BERNAUDIN, Myriam
IPC分类号: B01J13/00
摘要: The present invention relates to a method for the preparation of a colloidal aqueous suspension of stable zeolite nanocrystals having framework structures comprising at least one cation selected from Gd, Fe, Cu and Ag, said structures being loaded with a gas selected from O 2 , CO 2 and mixtures thereof, to the colloidal aqueous suspension of zeolite nanocrystals obtained by such a process, and to the use of said suspension in therapy, more particularly in cancer therapy and hypoxia-related diseases and/or in diagnosis.
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公开(公告)号:EP3102610A1
公开(公告)日:2016-12-14
申请号:EP15706386.8
申请日:2015-02-09
申请人: Katholieke Universiteit Leuven , INSERM - Institut National de la Santé et de la Recherche Médicale , Université de Caen Basse Normandie , Centre Hospitalier Universitaire de Caen
发明人: DECLERCK, Paul , DE MEYER, Simon , GEUKENS, Nick , GILS, Ann , RUBIO, Marina , VIVIEN, Denis , WYSEURE, Tine
摘要: Disclosed herein is a bispecific inhibitor for use in treating thrombotic disorders, such as acute thrombotic disorders like stroke and thromboembolism. The bispecific inhibitor is based on monoclonal antibodies targeting TAFI and PAI-1, and shows efficacy in the presence or the absence of plasminogen activators such as tissue-type plasminogen activator (tPA).
摘要翻译: 本文公开了用于治疗血栓形成疾病(例如急性血栓形成疾病如中风和血栓栓塞)的双特异性抑制剂。 双特异性抑制剂基于靶向TAFI和PAI-1的单克隆抗体,并且在存在或不存在纤溶酶原激活剂例如组织型纤溶酶原激活剂(tPA)的情况下显示功效。
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39.MCL-1 modulating compounds for cancer treatment 审中-公开
标题翻译: MCL-1-Modulationsverbindungen zur Krebsbehandlung公开(公告)号:EP2915811A1
公开(公告)日:2015-09-09
申请号:EP14305309.8
申请日:2014-03-04
申请人: Centre Régional de Lutte contre le Cancer - Centre François Baclesse , Université de Caen Basse Normandie , Institut de Cancérologie de l'Ouest René Gauducheau
发明人: Poulain, Laurent , Voisin-Chiret, Anne-Sophie , Sopkova-De Oliveira Santos, Jana , Bureau, Ronan , Burzicki, Grégory , De Giorgi, Marcella , Perato, Serge , Fogha, Jade , Rault, Sylvain , Juin, Philippe , Gautier, Fabien
IPC分类号: C07D401/14 , C07D409/14 , C07D213/22 , C07D213/30 , C07D213/55 , C07D213/57 , C07D213/58 , A61K31/506 , A61P35/00
CPC分类号: A61K31/444 , A61K31/506 , C07D213/22 , C07D213/30 , C07D213/55 , C07D213/57 , C07D213/58 , C07D401/14 , C07D409/14
摘要: The invention relates to compounds of formula (I), and to their therapeutic use in the treatment of cancer:
Wherein Y 3 , Y 2 , Ar 1 , Ar 2 , R 1 , R 2 , i, j, k, l are as defined in claim 1.摘要翻译: 本发明涉及式(I)化合物及其治疗癌症的治疗用途:其中Y 3,Y 2,Ar 1,Ar 2,R 1,R 2,i,j,k,l分别为 如权利要求1所述。
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40.COMPLEXES METALLIQUES DINUCLEAIRES GREFFES, ET LEUR UTILISATION EN TANT QUE CAPTEURS DE MICROPARTICULES CELLULAIRES 审中-公开
标题翻译: DINUKLEARE GEPFROPFTE METALLKOMPLEXE UND IHRE VERWENDUNG ALSZELLULÄREMIKROPARTIKELSENSOREN公开(公告)号:EP2688880A1
公开(公告)日:2014-01-29
申请号:EP12717367.2
申请日:2012-03-23
申请人: Centre National de la Recherche Scientifique (CNRS) , Université de Caen Basse Normandie , Université Joseph Fourier
IPC分类号: C07D401/14
CPC分类号: G01N33/54353 , C07D213/38 , C07D401/14 , C07F1/08 , C07F3/06
摘要: The invention relates to novel grafted dinuclear metal complexes of formula (I) or of formula (II) in which M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterizing cellular microparticles.
摘要翻译: 具有式(I)或式(II)的新型接枝的双核金属络合物,其中M表示金属离子,以及其作为用于检测和/或表征细胞微粒的方法中的传感器的用途。
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