公开(公告)号：EP0946138A2

公开(公告)日：1999-10-06

申请号：EP97913260.0

申请日：1997-11-06

申请人： LVMH RECHERCHE

发明人： BONTE, Frédéric ,  DUMAS, Marc ,  CHAUDAGNE, Catherine ,  MEYBECK, Alain

IPC分类号： C12N5 ,  A61K8 ,  A61K36 ,  A61P17 ,  A61Q1 ,  A61Q5 ,  A61Q19 ,  C07K14

CPC分类号： A61Q19/08 ,  A61K8/97 ,  A61K36/73 ,  A61Q5/00 ,  A61Q19/00 ,  C07K14/78 ,  A61K2300/00

摘要： The invention concerns the use of an extract of Potentilla erecta in the cosmetic and pharmaceutical field, in particular in dermatology. It concerns more particularly all the applications seeking to reinforce the dermo-epidermic junction or to improve hair condition, by improving the synthesis of collagen VII by keratinocytes and/or fibroblasts. Particularly, these applications concern the strengthening of the skin, the reduction of wrinkles or hair care. The invention also concerns a novel method of cell culture, in particular of human fibroblasts or keratinocytes, for promoting the formation of collagen VII.

公开(公告)号：EP0597025B1

公开(公告)日：1998-09-23

申请号：EP92917637.8

申请日：1992-07-30

申请人： LVMH RECHERCHE

发明人： MEYBECK, Alain ,  DUMAS, Marc ,  BONTE. Frédéric ,  MARECHAL, Christian

IPC分类号： A61K7/48 ,  A61K7/06 ,  A61K31/665 ,  A61K9/127 ,  C07F9/655

CPC分类号： C07F9/65522 ,  A61K8/678 ,  A61K31/355 ,  A61K31/665 ,  A61K2800/75 ,  A61K2800/782 ,  A61Q1/02 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/002 ,  Y10T428/2984

摘要： Use of a tocopherol phosphate, other than alpha-tocopherol phosphate, especially in its dl or d form, or one of its esters having general formula (I) in which: R' is hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, R'O is a tocopheryl radical; R'' is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, or R''O is an oxyethylene chain, of formula (a) in which R4 and R5 are independently a hydrogen atom or a methyl radical, and n is an integer of 1 or over; R1, R2 and R3 are independently a hydrogen atom or a methyl radical, it being understood that R1, R2 and R3 cannot simultaneously be a methyl radical. A represents the groups (b), or (c). The invention also concerns the use of cosmetically or of pharmaceutically acceptable salts of said compound in the preparation of a cosmetic or pharmaceutical, especially dermatological, composition characterized by having a reduced allergizing or irritating potential, or used in the prevention or treatment of allergic conditions, such as cutaneous allergy or bronchial or inflammatory asthma, or in the prevention or treatment of the harmful effects of free radicals.

公开(公告)号：EP0673238B1

公开(公告)日：1998-05-20

申请号：EP94902016.8

申请日：1993-12-10

申请人： LVMH RECHERCHE

发明人： BONTE, Frédéric ,  MEYBECK, Alain ,  DUMAS, Marc

IPC分类号： A61K7/48 ,  A61K7/06 ,  A61K35/78

CPC分类号： C12N5/0629 ,  A61K8/97 ,  A61K36/185 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q19/02 ,  C12N5/0626 ,  C12N2500/76 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/39 ,  C12N2501/81 ,  A61K2300/00

公开(公告)号：EP0835121A1

公开(公告)日：1998-04-15

申请号：EP96924025.0

申请日：1996-06-27

申请人： LVMH RECHERCHE

发明人： BONTE, Frédéric ,  DUMAS, Marc ,  LAVAUD, Catherine ,  MASSIOT, Georges

IPC分类号： A61K8 ,  A61K9 ,  A61K36 ,  A61Q1 ,  A61Q5 ,  A61Q19 ,  C07J3 ,  C07J71 ,  C07J73 ,  C12N5 ,  A61Q7

CPC分类号： A61Q19/00 ,  A61K8/97 ,  A61K36/23 ,  A61K36/77 ,  A61K36/899 ,  A61K2800/70 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61K2300/00

摘要： A cosmetic or pharmaceutical and particularly dermatological composition including, as the active ingredient, an extract of plants of genus Filicium, and particularly an extract of plants of species Filicium decipiens, preferably in an amount of 0.0001-3 wt % based on the total weight of the final composition. Said composition has the property of stimulating the production of glycosaminoglycans in the skin, both in the dermis and in the epidermis, and may be used for skin and hair care, in particular given its moisturising activity. Said extracts may also be used for stimulating glycosaminoglycan synthesis in cell culture media, particularly keratinocyte and fibroblast culture media.

公开(公告)号：EP0751777A1

公开(公告)日：1997-01-08

申请号：EP95914381.0

申请日：1995-03-17

申请人： LVMH RECHERCHE

发明人： MEYBECK, Alain ,  BONTE, Frédéric ,  DUMAS, Marc ,  CHAUDAGNE, Catherine

IPC分类号： C07H13 ,  A61K8 ,  A61K31 ,  A61K36 ,  A61P17 ,  A61P43 ,  A61Q19 ,  C07D207 ,  C07H15

CPC分类号： A61K8/63 ,  A61K31/70 ,  A61K36/258 ,  A61Q19/08 ,  Y10S514/828 ,  Y10S514/887

摘要： The use of ginsenoside Ro or a plant extract containing same to prepare a cosmetic or pharmaceutical composition, particularly a skin care composition, for promoting collagen synthesis, particularly collagen I and/or collagen III synthesis. Said cosmetic or pharmaceutical composition is administered to a mammal, particularly a human being, in order to promote collagen synthesis. A method for promoting collagen synthesis in fibroblast growth media is also disclosed.

公开(公告)号：EP0673237A1

公开(公告)日：1995-09-27

申请号：EP94902015.0

申请日：1993-12-10

申请人： LVMH RECHERCHE

发明人： BONTE, Frédéric ,  MEYBECK, Alain ,  DUMAS, Marc

IPC分类号： A61K8 ,  A61K36 ,  A61P17 ,  A61Q5 ,  A61Q19 ,  C12N5

CPC分类号： A61K36/185 ,  A61K8/14 ,  A61K8/347 ,  A61K8/365 ,  A61K8/37 ,  A61K8/44 ,  A61K8/4973 ,  A61K8/63 ,  A61K8/64 ,  A61K8/671 ,  A61K8/676 ,  A61K8/735 ,  A61K8/97 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C12N5/0629 ,  C12N2500/76 ,  A61K2300/00

摘要： A simaba extract is used to produce a cosmetic or pharmaceutical, and particularly dermatological, composition or a skin cell culture medium. The resulting compositions are also disclosed. The simaba extract has a significant skin depigmentation activity and can enhance the protective function of the skin, particularly its water barrier function, as well as having a significant keratinocyte differentiation activity.

公开(公告)号：EP0486595B1

公开(公告)日：1995-02-08

申请号：EP90912872.0

申请日：1990-08-14

申请人： LVMH RECHERCHE

发明人： MEYBECK, Alain ,  BONTE, Frédéric ,  DUMAS, Marc ,  ANDRE, Patrice ,  REDZINIAK, Gérard

IPC分类号： A61K7/48 ,  A61K35/78

CPC分类号： A61Q19/04 ,  A61K8/44 ,  A61K8/4953 ,  A61K8/675 ,  A61K8/97 ,  A61K36/53 ,  A61Q5/10 ,  A61K2300/00

摘要： The invention relates to the use of a coleus extract. In particular, the invention relates to the use of an extract of coleus forskohlii roots in order to prepare a cosmetic or pharmaceutical, and especially dermatological, composition which promotes skin pigmentation. The invention efficiently promotes skin pigmentation.

公开(公告)号：EP0597025A1

公开(公告)日：1994-05-18

申请号：EP92917637.0

申请日：1992-07-30

申请人： LVMH RECHERCHE

发明人： MEYBECK, Alain ,  DUMAS, Marc ,  BONTE. Frédéric ,  MARECHAL, Christian

IPC分类号： A61K8 ,  A61K9 ,  A61K31 ,  A61K36 ,  A61Q1 ,  A61Q17 ,  A61Q19 ,  C07F9

CPC分类号： C07F9/65522 ,  A61K8/678 ,  A61K31/355 ,  A61K31/665 ,  A61K2800/75 ,  A61K2800/782 ,  A61Q1/02 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/002 ,  Y10T428/2984

摘要： La présente invention concerne l'utilisation d'un phosphate de tocophérol, autre que le phosphate d'alpha-tocophérol, notamment sous sa forme dl ou d, ou de l'un de ses esters, de formule générale (I) dans laquelle: R' représente un atome d'hydrogène, un radical alkyle ayant de 1 à 4 atomes de carbone, tel qu'en particulier le radical méthyle ou éthyle, R'O représente un radical tocophéryle; R'' représente un atome d'hydrogène, un radical alkyle ayant de 1 à 4 atomes de carbone, tel qu'un particulier le radical méthyle ou éthyle, ou R''O représente une chaîne oxyéthylénée, de formule (a) dans laquelle R4 et R5 représentent indépendamment un atome d'hydrogène ou un radical méthyle, et n représente un nombre entier supérieur ou égal à 1; R1, R2 et R3 représentent indépendamment un atome d'hydrogène ou un radical méthyle, étant entendu que R1, R2 et R3 ne peuvent pas représenter simultanément un radical méthyle. A représente les groupes (b), ou (c) ou de l'un de ses sels, cosmétiquement ou pharmaceutiquement acceptables, pour la préparation d'une composition cosmétique ou pharmaceutique, notamment dermatologique, à potentiel allergisant ou irritant réduit, ou destiné à la prévention ou au traitement des manifestations allergiques, telles que l'allergie cutanée ou l'asthme bronchique, ou inflammatoire, ou à la prévention ou au traitement des effets nocifs des radicaux libres.