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313 条记录 (耗时 0.019 秒)

    Process for the production of penicillanic acid compounds
    31.
    发明公开
    Process for the production of penicillanic acid compounds 失效
    生产青霉烷酸化合物的方法

    公开(公告)号：EP0382863A1

    公开(公告)日：1990-08-22

    申请号：EP89102476.2

    申请日：1989-02-14

    申请人： Yoshitomi Pharmaceutical Industries, Ltd.

    发明人： Saeki, Kazumi ,  Hirano, Masami ,  Oka, Kunihide ,  Tsukinuki, Kazuto ,  Oikawa, Setsuo

    IPC分类号： C07D499/08 ,  C07D499/00

    CPC分类号： C07D499/00 ,  G05B2219/25249

    摘要： A process for the production of penicllic acid compounds, especially chloromethyl ester of penicillin G, penicillin V or sulbactam by esterification in the presence of a phase transfer catalyst of the general formula
    (R¹)(R²)(R³) (R⁴)NX      (III)
    wherein R¹, R², R³ and R⁴ are the same or different and each is an alkyl or aralkyl group and X is a hydroxide, chloride, bromide or hydrogensulfate ion.

    摘要翻译： 在通式（R 1）（R 2）（R 3）（R 4）NX（III）的相转移催化剂存在下酯化生产青霉酸化合物，特别是青霉素G，青霉素V或舒巴坦的氯甲基酯的方法 ）其中R 1，R 2，R 3和R 4相同或不同，各自是烷基或芳烷基，X是氢氧化物，氯化物，溴化物或硫酸氢根离子。

    Quinolonecarboxylic acid compounds and pharmaceutical use thereof
    33.
    发明公开
    Quinolonecarboxylic acid compounds and pharmaceutical use thereof 失效
    喹喔啉羧酸化合物及其药物用途

    公开(公告)号：EP0311948A3

    公开(公告)日：1990-05-09

    申请号：EP88116770.4

    申请日：1988-10-10

    申请人： Yoshitomi Pharmaceutical Industries, Ltd.

    发明人： Araki, Kazuhiko ,  Kuroda, Tsuyoshi ,  Uemori, Satoru ,  Moriguchi, Akihiko ,  Ikeda, Yoshifumi

    IPC分类号： C07D413/04 ,  A61K31/535

    CPC分类号： C07D413/04

    摘要： A quinolonecarboxylic acid compound of the formula I
    wherein R¹ is an alkyl group, a cycloalkyl group, a haloalkyl group, an alkenyl group, mono- or di-alkylamino groups, a phenyl group or a substituted phenyl group by one to three substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxy group, a hydroxy group, a nitro group or an amino group, R² is a hydrogen atom, an alkyl group, a cycloalkyl group, an acyl group or an alkoxy­carbonyl group, R³ is a hydrogen atom, an alkyl group or an aralkyl group, or R² and R³ together with the adjacent nitrogen atom form heterocyclic ring, R⁴ is a hydrogen atom or an alkyl group, R⁵ is a hydrogen atom, an alkyl group, an aralkyl group or an ester residue which is readily hydrolyzable in vivo, X is a hydrogen atom, a halogen atom or an alkyl group, n is integer of 1 to 3, and a salt thereof, and pharmaceutical use thereof. Said compounds exhibit antibacterial activities and are useful for the treatment of various infectious diseases.

    Phosphite compounds
    35.
    发明公开
    Phosphite compounds 失效
    Phosphit-Verbindungen。

    公开(公告)号：EP0335262A2

    公开(公告)日：1989-10-04

    申请号：EP89105226.8

    申请日：1989-03-23

    申请人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. ,  MITSUBISHI PETROCHEMICAL CO., LTD.

    发明人： Hanayama, Naoki ,  Nakagawa, Kazuo ,  Onishi, Akiyoshi c/o Plastics Laboratory

    IPC分类号： C07F9/145 ,  C08K5/52

    CPC分类号： C09K15/322 ,  C07F9/145 ,  C08K5/526

    摘要： Phosphite compounds represented by the formula
    wherein R¹ stands for a tertiary hydrocarbyl group, R² stands for an alkyl group, an aralkyl group which may be substituted, an aryl group or a cycloalkyl group and n stands for 0, 1 or 2.
    Such compounds possess stabilizing action against organic materials, particularly antioxidant action, and are useful as antioxidants for preventing deterioration by oxidation of organic materials.

    摘要翻译： 由式表示的亚磷酸酯化合物，其中R 1表示叔烃基，R 2表示烷基，可被取代的芳烷基，芳基或环烷基，n表示 这种化合物具有对有机材料的稳定作用，特别是抗氧化作用，并且可用作防止有机材料氧化劣化的抗氧化剂。

    Benzolactam compounds and pharmaceutical uses thereof
    37.
    发明公开
    Benzolactam compounds and pharmaceutical uses thereof 失效
    Benzolaktam-Verbindungen und deren pharmazeutische Verwendungen。

    公开(公告)号：EP0322779A2

    公开(公告)日：1989-07-05

    申请号：EP88121561.0

    申请日：1988-12-23

    申请人： Yoshitomi Pharmaceutical Industries, Ltd.

    发明人： Murakami, Shu ,  Ikebe, Tsuguo ,  Hakamada, Ichiro ,  Anami, Koretake

    IPC分类号： C07K5/06 ,  A61K37/02

    CPC分类号： C07K5/06139 ,  A61K38/00

    摘要： Benzolactam compounds of the general formula
    or isomers thereof as well as salts thereof inclusive of hydrates and/or solvates forms thereof, and benzolactam compounds of the general formula
    wherein each of the symbols is as defined in the specification.
    The compound (I) exhibit antiamnesic activity, and are useful as brain function-improving drugs. The compounds (a) and (b) are useful as an intermediate for said compounds (I).

    摘要翻译： 通式的苯并内酰胺化合物或其异构体以及其盐，包括水合物和/或溶剂化物形式，以及通式为CHEM的苯并内酰胺化合物，其中每个符号如说明书中所定义。 化合物（I）表现出抗病毒活性，可用作脑功能改善药物。 化合物（a）和（b）可用作所述化合物（I）的中间体。

    PROCESS FOR PREPARING TETRAKIS (3-(3,5-DI-tert-BUTYL-4-HYDROXYPHENYL)PROPIONYLOXYMETHYL)METHANE
    40.
    发明公开
    PROCESS FOR PREPARING TETRAKIS (3-(3,5-DI-tert-BUTYL-4-HYDROXYPHENYL)PROPIONYLOXYMETHYL)METHANE 失效
    VERFAHREN ZUR HERSTELLUNG VON TETRAKIS（3-（3,5-二叔丁基-4-羟基苯基）丙炔基甲基）甲烷。

    公开(公告)号：EP0300056A1

    公开(公告)日：1989-01-25

    申请号：EP88901318.1

    申请日：1988-02-01

    申请人： Yoshitomi Pharmaceutical Industries, Ltd.

    发明人： GOHBAYASHI, Masayoshi ,  NARITA, Noritsugu ,  MARUNO, Makoto

    IPC分类号： C07C69/732 ,  C07C67/03

    CPC分类号： C07C67/03 ,  C07C69/732

    摘要： process for preparing tetrakis (3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyloxymethyl)methane by conducting an ester-exchange reaction of an alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate with pentaerythritol in the presence of a basic catalyst, which comprises conducting the reaction in the presence of bis (2,2,2-tris(hydroxymethyl)-ethoxy)-methane. This process enables highly pure tetrakis-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyloxymethyl)methane to be prepared in a good yield without the necessity of using a large amount of expensive alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate while yielding a reduced amount of by-products.

    摘要翻译： 制备四（3-（3,5-叔丁基-4-羟基苯基）丙酰氧基甲基）甲烷（I）。 在碱性催化剂存在下，季戊四醇与3-（3,5-二叔丁基-4-羟基苯基）丙酸烷基酯的酯交换和双（2,2,2-三（羟基甲基） 乙氧基）甲烷。