公开(公告)号：EP0190367B1

公开(公告)日：1990-01-17

申请号：EP85904155.0

申请日：1985-08-26

申请人： Yoshitomi Pharmaceutical Industries, Ltd.

发明人： TAHARA, Tetsuya ,  KAWAKAMI, Minoru ,  TAKEHARA, Shuzo ,  SAKAMORI, Masamitsu

IPC分类号： C07D237/36 ,  A61K31/50

CPC分类号： C07D401/04 ,  C07D237/36

摘要： Benzo ADh BDcinnoline compounds represented by general formula (I) wherein X and Y each represents hydrogen, halogen, trifluoromethyl, hydroxy, C1-4 alkyl, C1-4 alkoxy, amino, C2-4 alkanoylamido, nitro, cyano, or C2-4 alkanoyl, Ar represents phenyl or pyridyl optionally having at least one of halogen, trifluoromethyl, hydroxy, C1-4 alkyl, C1-4 alkoxy, amino, C2-4 alkanoylamido, nitro, and cyano, and dotted line represents a single or double bond), a process for their preparation, and a medicinal composition containing them. These compounds possess a strong affinity for benzodiazepine receptor and an anti-anxiety effect and are therefore useful for neutralizing excess administration anti-anxiety agents or as an anti-anxiety agent itself.

公开(公告)号：EP0181145A3

公开(公告)日：1986-12-30

申请号：EP85307838

申请日：1985-10-30

申请人： SMITH KLINE & FRENCH LABORATORIES LIMITED

发明人： WARRINGTON, BRIAN HERBERT

IPC分类号： C07D237/26 ,  C07D237/36 ,  A61K31/50

CPC分类号： C07D237/36 ,  C07D237/26

公开(公告)号：EP0169443A3

公开(公告)日：1986-12-30

申请号：EP85108605

申请日：1985-07-10

申请人： BOEHRINGER BIOCHEMIA ROBIN S.P.A.

发明人： CIGNARELLA, GIORGIO ,  GANDOLFI, CARMELO A. ,  TOFANETTI, ODOARDO ,  CIPOLLA, PIERVITTO ,  TOGNELLA, SERGIO

IPC分类号： A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  C07C45/46 ,  C07C49/792 ,  C07C59/84 ,  C07C205/56 ,  C07D237/26 ,  C07D237/36

CPC分类号： C07D237/36 ,  C07C45/46 ,  C07C49/792 ,  C07C59/84 ,  C07C205/56 ,  C07D237/26

摘要： The tricyclic dihydropyridazinone derivatives having formula I

公开(公告)号：EP0190367A1

公开(公告)日：1986-08-13

申请号：EP85904155.0

申请日：1985-08-26

申请人： Yoshitomi Pharmaceutical Industries, Ltd.

发明人： TAHARA, Tetsuya ,  KAWAKAMI, Minoru ,  TAKEHARA, Shuzo ,  SAKAMORI, Masamitsu

IPC分类号： C07D237/36 ,  A61K31/50

CPC分类号： C07D401/04 ,  C07D237/36

摘要： Benzo[h]cinnoline compounds represented by general formula (I) wherein X and Y each represents hydrogen, halogen, trifluoromethyl, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, amino, C 2-4 alkanoylamido, nitro, cyano, or C 2-4 alkanoyl, Ar represents phenyl or pyridyl optionally having at least one of halogen, trifluoromethyl, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, amino, C 2-4 alkanoylamido, nitro, and cyano, and dotted line represents a single or double bond), a process for their preparation, and a medicinal composition containing them. These compounds possess a strong affinity for benzodiazepine receptor and an anti-anxiety effect and are therefore useful for neutralizing excess administration anti-anxiety agents or as an anti-anxiety agent itself.