公开(公告)号：EP2207571A4

公开(公告)日：2011-11-23

申请号：EP08747606

申请日：2008-05-02

申请人： FENG DEREK D

发明人： FENG DEREK D

IPC分类号： A61K49/00 ,  G01R33/50 ,  G01R33/54 ,  G01R33/60

CPC分类号： G01R33/54 ,  G01R33/445 ,  G01R33/50 ,  G01R33/5608 ,  G01R33/60

公开(公告)号：EP1999493A4

公开(公告)日：2010-03-17

申请号：EP07758331

申请日：2007-03-12

申请人： XIGO NANOTOOLS LLC

发明人： RACE SEAN ,  FAIRHURST DAVID ,  BROZEL MICHAEL

IPC分类号： G01V3/00 ,  G01N24/08 ,  G01R33/38 ,  G01R33/44 ,  G01R33/50

CPC分类号： G01N24/08 ,  G01N24/085 ,  G01R33/3806 ,  G01R33/383 ,  G01R33/44 ,  G01R33/50

公开(公告)号：EP1998185A1

公开(公告)日：2008-12-03

申请号：EP08103693.1

申请日：2008-04-23

申请人： Stelar S.r.l.

发明人： CANINA, Davide ,  SYKORA, Stanislav ,  FERRANTE, Gianni ,  MARTINI, Giuseppe ,  GOLZI, Paolo

IPC分类号： G01R33/50

CPC分类号： G01R33/50

摘要： A method has been conceived for acquisition and accumulation of a magnetic resonance signal in the presence of signal instability due to field or frequency instability. After submitting an element to be examined to a suitable experiment, a sequence of pulses for example, for measurement of an echo signal (Hahn-echo experiment), the detected signal for each τ is broken up into its Cartesian co-ordinates in an IQ plane, the module of the components is calculated and then the calculated modules are added to each other.
By operating on the sum of the calculated modules for each τ in order to at least partly remove the introduced noise, interpolation of the calculated points can be carried out so as to determine a course representative of the acquired and accumulated parameter as a function of τ.

摘要翻译： 在存在由于场或频率不稳定性引起的信号不稳定性的情况下，已经考虑了用于采集和累积磁共振信号的方法。 在将要检查的元件提交到合适的实验之后，例如用于测量回波信号（Hahn-echo实验）的脉冲序列，每个Ä的检测信号被分解成其在IQ中的笛卡尔坐标 平面，计算组件的模块，然后将计算出的模块相加。 通过对每个Ä计算的模块的总和进行操作，以便至少部分地去除引入的噪声，可以执行计算的点的内插，以便确定表示所获取和累积参数的路线作为Ä的函数 。

公开(公告)号：EP1322224B1

公开(公告)日：2008-11-05

申请号：EP01970941.9

申请日：2001-09-14

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： LANG, Philipp ,  STEINES, Daniel

IPC分类号： A61B5/055 ,  A61B5/103 ,  G01R33/50 ,  G01R33/56 ,  G06T5/00 ,  G06T7/00

CPC分类号： G06T7/0081 ,  A61B5/055 ,  A61B5/1038 ,  A61B5/107 ,  A61B5/1075 ,  A61B5/4514 ,  A61B5/4528 ,  A61B5/7257 ,  A61B6/03 ,  A61B8/0875 ,  G01R33/50 ,  G01R33/56 ,  G01R33/5608 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/187 ,  G06T2207/10088 ,  G06T2207/30008

摘要： Methods are disclosed for assessing the condition of a cartilage in a joint and assessing cartilage loss, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. The amount of cartilage tissue that has been lost, for example as a result of arthritis, can be estimated.

摘要翻译： 公开了用于评估关节软骨状况并评估软骨损失的方法，特别是在人类膝盖中。 所述方法包括将诸如MRI的图像转换成软骨的三维图。 软骨图可以与关节的运动模式相关联，以评估运动对软骨磨损的影响。 随着时间的推移，可以确定软骨厚度的变化，从而可以提供治疗。 可以估计已经失去的软骨组织的量，例如由于关节炎引起的。

公开(公告)号：EP1927008A1

公开(公告)日：2008-06-04

申请号：EP06815101.8

申请日：2006-09-21

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： MISTRETTA, Charles, A. ,  REEDER, Scott ,  PERRY, John ,  WIEBEN, Oliver

IPC分类号： G01R33/561 ,  G01R33/50 ,  G01R33/563

CPC分类号： G06T11/006 ,  G01R33/4824 ,  G01R33/485 ,  G01R33/50 ,  G01R33/561 ,  G01R33/56341 ,  G06T2211/412 ,  G06T2211/424

摘要： A series of image frames are acquired in which an MR parameter such as echo time (TE) is changed and the resulting image frames are employed to produce an MRS image of a metabolite. Scan time is reduced without sacrificing image quality by reconstructing a composite image from data acquired for a plurality of the image frames and using a highly constrained backprojection method wherein each backproject pixel value of a projection view is weighted by the value of the corresponding pixel in the composite image to produce each image frame. In another embodiment, this technique is used for T2 qualification.

公开(公告)号：EP1287373B1

公开(公告)日：2008-05-14

申请号：EP01943120.4

申请日：2001-05-19

申请人： Forschungszentrum Jülich GmbH

发明人： SHAH, Nadim, Joni ,  STEINHOFF, Sven ,  ZAITSEV, Maxim

IPC分类号： G01R33/50

CPC分类号： G01R33/50 ,  G01R33/4835

摘要： The invention relates to a pulse train, to a nuclear magnetic resonance tomograph, which comprises means for generating this pulse train, and to an imaging method, in which the inventive pulse train is used. The inventive pulse train comprises a alpha -high frequency pulse, a preceding 180 DEG pulse or a preceding 180 DEG pulse, a 90 DEG pulse that precedes the 180 DEG pulse, as well as layer selection, a k space line coding and an acquisition module, which is subsequent thereto and which is provided for generating data. The invention is characterized in that the acquisition module for generating data results from at least two layers. By using the inventive pulse sequence and imaging method, 20 layers of an image can be acquired at 16 different points in time for a matrix size of 256 x 256 during a measuring time of 8 minutes and 28 seconds. As a result, T1 relaxation times can be used for the first time for imaging methods in medical diagnosis.

公开(公告)号：EP1891455A2

公开(公告)日：2008-02-27

申请号：EP06745015.5

申请日：2006-05-24

申请人： Philips Intellectual Property & Standards GmbH ,  Koninklijke Philips Electronics N.V.

发明人： DAHNKE, Hannes c/o Philips Intellectual Property & ,  SCHAEFFTER, Tobias c/o Philips Intellectual Proper

IPC分类号： G01R33/028 ,  G01R33/50

CPC分类号： G01R33/5601 ,  G01R33/50

摘要： MR based molecular imaging is used for the quantification of contrast agent concentrations. According to an exemplary embodiment of the present invention, a difference between R2 and R2* relaxation rates of a contrast agent is determined on the basis of data measured after contrast agent application. This may provide for an in vivo information relating to a compartmentalization or binding status of the contrast agent, and thus may improve the significance of the examination result.

公开(公告)号：EP1784654A1

公开(公告)日：2007-05-16

申请号：EP05781079.8

申请日：2005-08-19

申请人： Philips Intellectual Property & Standards GmbH ,  Koninklijke Philips Electronics N.V.

发明人： Katscher, Ulrich ,  Dahnke, Hannes

IPC分类号： G01R33/50

CPC分类号： G01R33/50 ,  G01R33/58

摘要： The invention relates to an MR method of determining local relaxation time values (T1, T2) of an examination object (5). Firstly, two or more MR images (3, 4) of the examination object (5) are recorded, each with different time parameter sets (TR1, TE1, TR2, TE2) of an imaging sequence. MR images (6, 7) of a phantom are likewise recorded, wherein the same time parameter sets (TR1, TE1, TR2, TE2) of the imaging sequence are used and wherein the phantom has a known spatial distribution of relaxation time values (T1, T2). The local relaxation time values (T1, T2) of the examination object (5) are determined by comparing image values of the MR images (3, 4) of the examination object (5) with image values of the MR images (6, 7) of the phantom and by assigning image values of the MR images (6, 7) of the phantom to relaxation time values (T1, T2) according to the known spatial distribution of relaxation time values (T1, T2) of the phantom.

公开(公告)号：EP1740968A1

公开(公告)日：2007-01-10

申请号：EP05716457.6

申请日：2005-03-30

申请人： Forschungszentrum Jülich GmbH

发明人： SHAH, N., Joni

IPC分类号： G01R33/50

CPC分类号： G01R33/50 ,  G01R33/446

摘要： An imaging process is disclosed, as well as a nuclear spin tomograph for generating mainly T1-weighted images with high signal-to-noise ratio and high spatial resolution. According to the invention, the imaging process is characterised in that it comprises at least one data acquisition module including at least one layer-selective α high-frequency impulse and magnetic gradients (Gx, Gy, Gz) for layer selection and/or encoding of a k-space. Acquired data describe a spin-lattice relaxation moment, the data acquisition module being repeated for acquiring data on at least one additional moment. Moreover, at least one 180° high-frequency impulse or at least one 180° high-frequency impulse and at least one 90° high-frequency impulse that precedes the 180° high-frequency impulse is connected upstream of the data acquisition module in order to generate spin-lattice relaxation. The magnetic gradients Gx and Gy are switched after the layer-selective α high-frequency impulse for k-space encoding, with a sinusoidal variation-in-time curve of the magnetic gradients Gx and Gy, so as to cover in a spiral the k-space, additional data being acquired during k-space encoding.

公开(公告)号：EP1618404A1

公开(公告)日：2006-01-25

申请号：EP04727081.4

申请日：2004-04-13

申请人： Philips Intellectual Property & Standards GmbH ,  Koninklijke Philips Electronics N.V.

发明人： EGGERS, Holger, Philips IP & Standards GmbH ,  SCHÄFFTER, Tobias, Philips IP & Standards GmbH ,  BÖRNERT, Peter, Philips IP &Standards GmbH

IPC分类号： G01R33/50 ,  G01R33/561

CPC分类号： G01R33/56554 ,  G01R33/565 ,  G01R33/56536

摘要： The invention relates to a method for generating an MR image of an object situated in an examination volume of an MR apparatus. The method begins with the acquisition of a plurality of echo signals having at least two different echo-time values (ti, t2, t3), the echo signals being generated from high-frequency pulses and magnetic-field gradient pulses by means of an imaging sequence. An intermediate MR image (5, 6, 7) is then reconstructed for each echo-time value (ti, t2, t3). By analyzing these intermediate MR images (5, 6, 7), local relaxation times (T2*(x)) and/or local frequency shifts (Aw(x)) are determined by taking account of the respective echo-time values (t1, t2, t3). Finally, a definitive MR image (11) is reconstructed from the echo signals (1) in their entirety.