公开(公告)号：EP0702525A1

公开(公告)日：1996-03-27

申请号：EP94919167.0

申请日：1994-05-19

申请人： E-Z-EM, INC.

发明人： DAVIS, Michael, A. ,  ZWARUN, Andrew, A.

IPC分类号： A61B5 ,  A61K49 ,  G01R33

CPC分类号： G01R33/5601 ,  A61K49/1806 ,  Y10T436/24

摘要： A negative contrast agent for MRI is an aqueous suspension having a quantity of barium sulfate between 25 and 40 percent by weight and a quantity of bentonite between two and four percent by weight. Such a negative contrast agent provides dark imaging in a T2 weighted pulse sequence; namely a relative signal intensity (RSI) approaching zero. It also provides a relative signal intensity (RSI) of under thirty percent of that of a reference that approximates tissue in a T1 weighted pulse sequence.

公开(公告)号：EP0446715A3

公开(公告)日：1992-07-29

申请号：EP91103065.8

申请日：1991-03-01

申请人： E-Z-EM, INC.

发明人： Goodman, John ,  Hawkins, Irvin F. ,  Hobbs, Eamonn ,  Zimmet, Arthur L.

IPC分类号： A61B1/12 ,  A61M5/00 ,  A61M13/00

CPC分类号： A61B6/481 ,  A61B5/0215 ,  A61B5/411 ,  A61B6/504 ,  A61B6/541 ,  A61B18/245 ,  A61M5/007 ,  A61M2202/0225 ,  A61M2210/12 ,  A61M2230/04 ,  A61M2202/0007 ,  A61M2230/005

摘要： An apparatus (10) is provided to deliver carbon dioxide to an animal in a manner which allows the carbon dioxide to totally displace blood in an area of interest and to thus serve as a contrast media for angiographic procedures, or blood displacement media for angioscopic or laser procedures. The apparatus enables the carbon dioxide to flow at varied flow rates, the varied flow rates correlated to the varied flow rate of blood in the animal's vascular system. The flow rate of the carbon dioxide is variable during the course of a single injection.

公开(公告)号：EP0446715A2

公开(公告)日：1991-09-18

申请号：EP91103065.8

申请日：1991-03-01

申请人： E-Z-EM, INC.

发明人： Goodman, John ,  Hawkins, Irvin F. ,  Hobbs, Eamonn ,  Zimmet, Arthur L.

IPC分类号： A61B1/12 ,  A61M5/00 ,  A61M13/00

CPC分类号： A61B6/481 ,  A61B5/0215 ,  A61B5/411 ,  A61B6/504 ,  A61B6/541 ,  A61B18/245 ,  A61M5/007 ,  A61M2202/0225 ,  A61M2210/12 ,  A61M2230/04 ,  A61M2202/0007 ,  A61M2230/005

摘要： An apparatus (10) is provided to deliver carbon dioxide to an animal in a manner which allows the carbon dioxide to totally displace blood in an area of interest and to thus serve as a contrast media for angiographic procedures, or blood displacement media for angioscopic or laser procedures. The apparatus enables the carbon dioxide to flow at varied flow rates, the varied flow rates correlated to the varied flow rate of blood in the animal's vascular system. The flow rate of the carbon dioxide is variable during the course of a single injection.

摘要翻译： 提供了一种设备，其以使得二氧化碳完全置换感兴趣区域中的血液并因此用作血管造影术的造影剂或血管透视或激光手术的血液置换介质的方式向动物输送二氧化碳。 该装置能够使二氧化碳以不同的流速流动，不同的流速与动物血管系统中血液的不同流速相关。 在单次注射过程中二氧化碳的流量是可变的。